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| | '''Serine/threonine-protein kinase LATS2''' is an [[enzyme]] that in humans is encoded by the ''LATS2'' [[gene]].<ref name="pmid10673337">{{cite journal |vauthors=Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H | title = Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts | journal = Genomics | volume = 63 | issue = 2 | pages = 263–70 |date=Apr 2000 | pmid = 10673337 | pmc = | doi = 10.1006/geno.1999.6065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref> | ||
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| summary_text = This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = | | summary_text = This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a [[positive feedback]] loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref> | ||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T |title=Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. |journal=Oncogene |volume=19 |issue= 27 |pages= 3101–9 |year= 2000 |pmid= 10871863 |doi= 10.1038/sj.onc.1203659 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | |||
*{{cite journal | *{{cite journal |vauthors=Li Y, Pei J, Xia H, etal |title=Lats2, a putative tumor suppressor, inhibits G1/S transition. |journal=Oncogene |volume=22 |issue= 28 |pages= 4398–405 |year= 2003 |pmid= 12853976 |doi= 10.1038/sj.onc.1206603 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Powzaniuk M, McElwee-Witmer S, Vogel RL, etal |title=The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. |journal=Mol. Endocrinol. |volume=18 |issue= 8 |pages= 2011–23 |year= 2005 |pmid= 15131260 |doi= 10.1210/me.2004-0065 }} | ||
*{{cite journal | *{{cite journal |vauthors=Toji S, Yabuta N, Hosomi T, etal |title=The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. |journal=Genes Cells |volume=9 |issue= 5 |pages= 383–97 |year= 2005 |pmid= 15147269 |doi= 10.1111/j.1356-9597.2004.00732.x }} | ||
*{{cite journal | *{{cite journal |vauthors=Ke H, Pei J, Ni Z, etal |title=Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). |journal=Exp. Cell Res. |volume=298 |issue= 2 |pages= 329–38 |year= 2004 |pmid= 15265683 |doi= 10.1016/j.yexcr.2004.04.031 }} | ||
*{{cite journal | *{{cite journal |vauthors=Chan EH, Nousiainen M, Chalamalasetty RB, etal |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076–86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445 }} | ||
*{{cite journal | *{{cite journal |vauthors=Takahashi Y, Miyoshi Y, Takahata C, etal |title=Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. |journal=Clin. Cancer Res. |volume=11 |issue= 4 |pages= 1380–5 |year= 2005 |pmid= 15746036 |doi= 10.1158/1078-0432.CCR-04-1773 }} | ||
*{{cite journal | *{{cite journal |vauthors=Abe Y, Ohsugi M, Haraguchi K, etal |title=LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. |journal=FEBS Lett. |volume=580 |issue= 3 |pages= 782–8 |year= 2006 |pmid= 16413547 |doi= 10.1016/j.febslet.2005.12.096 }} | ||
*{{cite journal | *{{cite journal |vauthors=Voorhoeve PM, le Sage C, Schrier M, etal |title=A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. |journal=Cell |volume=124 |issue= 6 |pages= 1169–81 |year= 2006 |pmid= 16564011 |doi= 10.1016/j.cell.2006.02.037 }} | ||
*{{cite journal | *{{cite journal |vauthors=Aylon Y, Michael D, Shmueli A, etal |title=A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. |journal=Genes Dev. |volume=20 |issue= 19 |pages= 2687–700 |year= 2007 |pmid= 17015431 |doi= 10.1101/gad.1447006 | pmc=1578695 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jiang Z, Li X, Hu J, etal |title=Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 450–8 |year= 2007 |pmid= 17049657 |doi= 10.1016/j.neures.2006.09.006 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{protein- | {{Serine/threonine-specific protein kinases}} | ||
{{ | {{Enzymes}} | ||
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Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.[1][2]
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.[2]
References
- ↑ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
- ↑ 2.0 2.1 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".
Further reading
- Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000). "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor". Oncogene. 19 (27): 3101–9. doi:10.1038/sj.onc.1203659. PMID 10871863.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Li Y, Pei J, Xia H, et al. (2003). "Lats2, a putative tumor suppressor, inhibits G1/S transition". Oncogene. 22 (28): 4398–405. doi:10.1038/sj.onc.1206603. PMID 12853976.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Powzaniuk M, McElwee-Witmer S, Vogel RL, et al. (2005). "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor". Mol. Endocrinol. 18 (8): 2011–23. doi:10.1210/me.2004-0065. PMID 15131260.
- Toji S, Yabuta N, Hosomi T, et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase". Genes Cells. 9 (5): 383–97. doi:10.1111/j.1356-9597.2004.00732.x. PMID 15147269.
- Ke H, Pei J, Ni Z, et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)". Exp. Cell Res. 298 (2): 329–38. doi:10.1016/j.yexcr.2004.04.031. PMID 15265683.
- Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
- Takahashi Y, Miyoshi Y, Takahata C, et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers". Clin. Cancer Res. 11 (4): 1380–5. doi:10.1158/1078-0432.CCR-04-1773. PMID 15746036.
- Abe Y, Ohsugi M, Haraguchi K, et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 (3): 782–8. doi:10.1016/j.febslet.2005.12.096. PMID 16413547.
- Voorhoeve PM, le Sage C, Schrier M, et al. (2006). "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors". Cell. 124 (6): 1169–81. doi:10.1016/j.cell.2006.02.037. PMID 16564011.
- Aylon Y, Michael D, Shmueli A, et al. (2007). "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization". Genes Dev. 20 (19): 2687–700. doi:10.1101/gad.1447006. PMC 1578695. PMID 17015431.
- Jiang Z, Li X, Hu J, et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma". Neurosci. Res. 56 (4): 450–8. doi:10.1016/j.neures.2006.09.006. PMID 17049657.
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