PITPNM1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Membrane-associated phosphatidylinositol transfer protein 1''' is a [[protein]] that in humans is encoded by the ''PITPNM1'' [[gene]].<ref name="pmid9680295">{{cite journal | vauthors = Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S | title = A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms | journal = Genes Funct. | volume = 1 | issue = 3 | pages = 205–13 | year = 1997 | date = Aug 1998 | pmid = 9680295 | pmc =  | doi = 10.1046/j.1365-4624.1997.00015.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9600| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phosphatidylinositol transfer protein, membrane-associated 1
| HGNCid = 9003
| Symbol = PITPNM1
| AltSymbols =; DRES9; FLJ44997; NIR2; PITPNM; RDGB; RDGB1; RDGBA1; Rd9
| OMIM = 608794
| ECnumber = 
| Homologene = 3608
| MGIid = 1197524
| GeneAtlas_image1 = PBB_GE_PITPNM1_203826_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008526 |text = phosphatidylinositol transporter activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9600
    | Hs_Ensembl = ENSG00000110697
    | Hs_RefseqProtein = NP_004901
    | Hs_RefseqmRNA = NM_004910
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 67015815
    | Hs_GenLoc_end = 67029366
    | Hs_Uniprot = O00562
    | Mm_EntrezGene = 18739
    | Mm_Ensembl = ENSMUSG00000024851
    | Mm_RefseqmRNA = NM_008851
    | Mm_RefseqProtein = NP_032877
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 4100117
    | Mm_GenLoc_end = 4113964
    | Mm_Uniprot = O35954
  }}
}}
'''Phosphatidylinositol transfer protein, membrane-associated 1''', also known as '''PITPNM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9600| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9600| accessdate = }}</ref>
}}


==References==
It was found that aggressive [[Metastasis|metastasized cancer cells]] produced more of the PITPNC1 protein. In contrast, [[tumor cells]] that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes [[Malignancy|malignant]] secretion by binding [[Golgi apparatus|Golgi]]-resident [[Phosphatidylinositol 4-phosphate|PI4P]] and localizing [[RAB1B]] to the Golgi. RAB1B localization to the Golgi allows for the recruitment of [[Golph3|GOLPH3]] (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced [[Vesicle (biology and chemistry)#Extracellular vesicles|vesicular]] release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators [[HTRA1]], [[MMP1]], [[FAM3C]], [[PDGFA]], and [[ADAM10]].<ref>{{cite journal | vauthors = Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF | year = 2016 | title = PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion | url = | journal = Cancer Cell | volume = 29 | issue = 3| pages = 339–353 | doi = 10.1016/j.ccell.2016.02.013 | pmid=26977884}}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
PITPNM1 has been shown to [[Protein-protein interaction|interact]] with [[PTK2B]].<ref name=pmid10022914>{{cite journal | vauthors = Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J | title = Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2278–88  | date = Mar 1999 | pmid = 10022914 | pmc = 84020 | doi=10.1128/mcb.19.3.2278}}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Vihtelic TS, Hyde DR, O'Tousa JE | title = Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene | journal = Genetics | volume = 127 | issue = 4 | pages = 761–8 | year = 1991 | pmid = 1903119 | pmc = 1204403 | doi =  }}
| citations =
* {{cite journal | vauthors = Aikawa Y, Hara H, Watanabe T | title = Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene | journal = Biochem. Biophys. Res. Commun. | volume = 236 | issue = 3 | pages = 559–64 | year = 1997 | pmid = 9245688 | doi = 10.1006/bbrc.1997.7009 }}
*{{cite journal | author=Vihtelic TS, Hyde DR, O'Tousa JE |title=Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene. |journal=Genetics |volume=127 |issue= 4 |pages= 761-8 |year= 1991 |pmid= 1903119 |doi=  }}
* {{cite journal | vauthors = Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J | title = Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2278–88 | year = 1999 | pmid = 10022914 | pmc = 84020 | doi =  10.1128/mcb.19.3.2278}}
*{{cite journal | author=Aikawa Y, Hara H, Watanabe T |title=Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 3 |pages= 559-64 |year= 1997 |pmid= 9245688 |doi= 10.1006/bbrc.1997.7009 }}
* {{cite journal | vauthors = Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S | title = Nir2, a novel regulator of cell morphogenesis | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2650–62 | year = 2002 | pmid = 11909959 | pmc = 133726 | doi = 10.1128/MCB.22.8.2650-2662.2002 }}
*{{cite journal | author=Rubboli F, Bulfone A, Bogni S, ''et al.'' |title=A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms. |journal=Genes Funct. |volume=1 |issue= 3 |pages= 205-13 |year= 1998 |pmid= 9680295 |doi=  }}
* {{cite journal | vauthors = Litvak V, Tian D, Carmon S, Lev S | title = Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis | journal = Mol. Cell. Biol. | volume = 22 | issue = 14 | pages = 5064–75 | year = 2002 | pmid = 12077336 | pmc = 139767 | doi = 10.1128/MCB.22.14.5064-5075.2002 }}
*{{cite journal  | author=Lev S, Hernandez J, Martinez R, ''et al.'' |title=Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2278-88 |year= 1999 |pmid= 10022914 |doi=  }}
* {{cite journal | vauthors = Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S | title = Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain | journal = Curr. Biol. | volume = 12 | issue = 17 | pages = 1513–8 | year = 2002 | pmid = 12225667 | doi = 10.1016/S0960-9822(02)01107-7 }}
*{{cite journal | author=Tian D, Litvak V, Toledo-Rodriguez M, ''et al.'' |title=Nir2, a novel regulator of cell morphogenesis. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2650-62 |year= 2002 |pmid= 11909959 |doi= }}
* {{cite journal | vauthors = Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S | title = Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion | journal = Mol. Cell | volume = 14 | issue = 3 | pages = 319–30 | year = 2004 | pmid = 15125835 | doi = 10.1016/S1097-2765(04)00214-X }}
*{{cite journal | author=Litvak V, Tian D, Carmon S, Lev S |title=Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5064-75 |year= 2002 |pmid= 12077336 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Litvak V, Shaul YD, Shulewitz M, ''et al.'' |title=Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. |journal=Curr. Biol. |volume=12 |issue= 17 |pages= 1513-8 |year= 2003 |pmid= 12225667 |doi= }}
* {{cite journal | vauthors = Amarilio R, Ramachandran S, Sabanay H, Lev S | title = Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction | journal = J. Biol. Chem. | volume = 280 | issue = 7 | pages = 5934–44 | year = 2005 | pmid = 15545272 | doi = 10.1074/jbc.M409566200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ocaka L, Spalluto C, Wilson DI, Hunt DM, Halford S | title = Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3 | journal = Cytogenet. Genome Res. | volume = 108 | issue = 4 | pages = 293–302 | year = 2005 | pmid = 15627748 | doi = 10.1159/000081519 }}
*{{cite journal | author=Litvak V, Argov R, Dahan N, ''et al.'' |title=Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. |journal=Mol. Cell |volume=14 |issue= 3 |pages= 319-30 |year= 2004 |pmid= 15125835 |doi= }}
* {{cite journal | vauthors = Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S | title = Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function | journal = Nat. Cell Biol. | volume = 7 | issue = 3 | pages = 225–34 | year = 2005 | pmid = 15723057 | doi = 10.1038/ncb1221 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Amarilio R, Ramachandran S, Sabanay H, Lev S |title=Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5934-44 |year= 2005 |pmid= 15545272 |doi= 10.1074/jbc.M409566200 }}
* {{cite journal | vauthors = Burgis NE, Cunningham RP | title = Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase | journal = J. Biol. Chem. | volume = 282 | issue = 6 | pages = 3531–8 | year = 2007 | pmid = 17090528 | doi = 10.1074/jbc.M608708200 }}
*{{cite journal | author=Ocaka L, Spalluto C, Wilson DI, ''et al.'' |title=Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3. |journal=Cytogenet. Genome Res. |volume=108 |issue= 4 |pages= 293-302 |year= 2005 |pmid= 15627748 |doi= 10.1159/000081519 }}
*{{cite journal | author=Litvak V, Dahan N, Ramachandran S, ''et al.'' |title=Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. |journal=Nat. Cell Biol. |volume=7 |issue= 3 |pages= 225-34 |year= 2005 |pmid= 15723057 |doi= 10.1038/ncb1221 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Burgis NE, Cunningham RP |title=Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. |journal=J. Biol. Chem. |volume=282 |issue= 6 |pages= 3531-8 |year= 2007 |pmid= 17090528 |doi= 10.1074/jbc.M608708200 }}
}}
{{refend}}
{{refend}}


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Revision as of 18:11, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.[1][2]

Function

PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM][2]

It was found that aggressive metastasized cancer cells produced more of the PITPNC1 protein. In contrast, tumor cells that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes malignant secretion by binding Golgi-resident PI4P and localizing RAB1B to the Golgi. RAB1B localization to the Golgi allows for the recruitment of GOLPH3 (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced vesicular release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM10.[3]

Interactions

PITPNM1 has been shown to interact with PTK2B.[4]

References

  1. ↑ Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (Aug 1998). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295. Check date values in: |year= / |date= mismatch (help)
  2. ↑ 2.0 2.1 "Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".
  3. ↑ Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF (2016). "PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion". Cancer Cell. 29 (3): 339–353. doi:10.1016/j.ccell.2016.02.013. PMID 26977884.
  4. ↑ Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. 19 (3): 2278–88. doi:10.1128/mcb.19.3.2278. PMC 84020. PMID 10022914.

Further reading


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