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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase MARK2''' is an [[enzyme]] that in humans is encoded by the ''MARK2'' [[gene]].<ref name="pmid9730619">{{cite journal | vauthors = Espinosa L, Navarro E | title = Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing | journal = Cytogenet Cell Genet | volume = 81 | issue = 3–4 | pages = 278–82 | date = Oct 1998 | pmid = 9730619 | pmc =  | doi = 10.1159/000015046 }}</ref><ref name="pmid10516437">{{cite journal | vauthors = Navarro E | title = Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search | journal = Cytogenet Cell Genet | volume = 86 | issue = 1 | pages = 66–7 | date = Oct 1999 | pmid = 10516437 | pmc = | doi = 10.1159/000015413 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MARK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y8g.
| PDB = {{PDB2|1y8g}}, {{PDB2|1zmu}}, {{PDB2|1zmv}}, {{PDB2|1zmw}}
| Name = MAP/microtubule affinity-regulating kinase 2
| HGNCid = 3332
| Symbol = MARK2
| AltSymbols =; EMK1; MGC99619; PAR-1
| OMIM = 600526
| ECnumber = 
| Homologene = 69013
| MGIid = 99638
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0015630 |text = microtubule cytoskeleton}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0045180 |text = basal cortex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045197 |text = establishment and/or maintenance of epithelial cell polarity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2011
    | Hs_Ensembl = ENSG00000072518
    | Hs_RefseqProtein = NP_001034557
    | Hs_RefseqmRNA = NM_001039468
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 63363517
    | Hs_GenLoc_end = 63433621
    | Hs_Uniprot = Q7KZI7
    | Mm_EntrezGene = 13728
    | Mm_Ensembl = ENSMUSG00000024969
    | Mm_RefseqmRNA = NM_001080388
    | Mm_RefseqProtein = NP_001073857
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 7344134
    | Mm_GenLoc_end = 7357829
    | Mm_Uniprot = Q3T9A3
  }}
}}
'''MAP/microtubule affinity-regulating kinase 2''', also known as '''MARK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
EMK (ELKL Motif Kinase) is a small family of ser/thr [[protein]] kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.<ref name="entrez">{{cite web | title = Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MARK2 has been shown to [[Protein-protein interaction|interact]] with [[AKT1]].<ref name=pmid18292230>{{cite journal | vauthors = Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L | title = Akt and CHIP coregulate tau degradation through coordinated interactions | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 105 | issue = 9 | pages = 3622–7 | date = Mar 2008 | pmid = 18292230 | pmc = 2265134 | doi = 10.1073/pnas.0709180105 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Courseaux A, Fernandes M, Grosgeorge J, Inglis J, Raynaud SD, Gaudray P | title = Human EMK1 is located on 11q12-q13, close to COX8 and FTH1 | journal = Mamm. Genome | volume = 6 | issue = 4 | pages = 311–2 | year = 1995 | pmid = 7613050 | doi = 10.1007/BF00352433 }}
| citations =
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Courseaux A, Fernandes M, Grosgeorge J, ''et al.'' |title=Human EMK1 is located on 11q12-q13, close to COX8 and FTH1. |journal=Mamm. Genome |volume=6 |issue= 4 |pages= 311-2 |year= 1995 |pmid= 7613050 |doi= }}
* {{cite journal | vauthors = Schultz SJ, Nigg EA | title = Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans | journal = Cell Growth Differ. | volume = 4 | issue = 10 | pages = 821–30 | year = 1994 | pmid = 8274451 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821-30 |year= 1994 |pmid= 8274451 |doi=  }}
* {{cite journal | vauthors = Courseaux A, Grosgeorge J, Gaudray P, Pannett AA, Forbes SA, Williamson C, Bassett D, Thakker RV, Teh BT, Farnebo F, Shepherd J, Skogseid B, Larsson C, Giraud S, Zhang CX, Salandre J, Calender A | title = Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1) | journal = Genomics | volume = 37 | issue = 3 | pages = 354–65 | year = 1997 | pmid = 8938448 | doi = 10.1006/geno.1996.0570 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E | title = MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption | journal = Cell | volume = 89 | issue = 2 | pages = 297–308 | year = 1997 | pmid = 9108484 | doi = 10.1016/S0092-8674(00)80208-1 }}
*{{cite journal | author=Courseaux A, Grosgeorge J, Gaudray P, ''et al.'' |title=Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1). |journal=Genomics |volume=37 |issue= 3 |pages= 354-65 |year= 1997 |pmid= 8938448 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Drewes G, Ebneth A, Preuss U, ''et al.'' |title=MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. |journal=Cell |volume=89 |issue= 2 |pages= 297-308 |year= 1997 |pmid= 9108484 |doi= }}
* {{cite journal | vauthors = Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT | title = PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling | journal = Nat. Cell Biol. | volume = 3 | issue = 7 | pages = 628–36 | year = 2001 | pmid = 11433294 | doi = 10.1038/35083016 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12804–11 | year = 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 }}
*{{cite journal | author=Espinosa L, Navarro E |title=Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 278-82 |year= 1998 |pmid= 9730619 |doi= }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Navarro E |title=Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 1 |pages= 66-7 |year= 1999 |pmid= 10516437 |doi= }}
* {{cite journal | vauthors = Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR | title = LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 | journal = EMBO J. | volume = 23 | issue = 4 | pages = 833–43 | year = 2005 | pmid = 14976552 | pmc = 381014 | doi = 10.1038/sj.emboj.7600110 }}
*{{cite journal | author=Sun TQ, Lu B, Feng JJ, ''et al.'' |title=PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. |journal=Nat. Cell Biol. |volume=3 |issue= 7 |pages= 628-36 |year= 2001 |pmid= 11433294 |doi= 10.1038/35083016 }}
* {{cite journal | vauthors = Hueso M, Beltran V, Moreso F, Ciriero E, Fulladosa X, Grinyó JM, Serón D, Navarro E | title = Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients | journal = Biochim. Biophys. Acta | volume = 1689 | issue = 1 | pages = 58–65 | year = 2004 | pmid = 15158914 | doi = 10.1016/j.bbadis.2004.01.008 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Brajenovic M, Joberty G, Küster B, ''et al.'' |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804-11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200 }}
* {{cite journal | vauthors = Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno S | title = aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1425–35 | year = 2004 | pmid = 15324659 | doi = 10.1016/j.cub.2004.08.021 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
* {{cite journal | vauthors = Cohen D, Rodriguez-Boulan E, Müsch A | title = Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 38 | pages = 13792–7 | year = 2004 | pmid = 15365179 | pmc = 518835 | doi = 10.1073/pnas.0403684101 }}
*{{cite journal | author=Lizcano JM, Göransson O, Toth R, ''et al.'' |title=LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. |journal=EMBO J. |volume=23 |issue= 4 |pages= 833-43 |year= 2005 |pmid= 14976552 |doi= 10.1038/sj.emboj.7600110 }}
* {{cite journal | vauthors = Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M | title = Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1 | journal = Cancer Res. | volume = 64 | issue = 20 | pages = 7361–9 | year = 2004 | pmid = 15492257 | doi = 10.1158/0008-5472.CAN-04-0823 }}
*{{cite journal | author=Hueso M, Beltran V, Moreso F, ''et al.'' |title=Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients. |journal=Biochim. Biophys. Acta |volume=1689 |issue= 1 |pages= 58-65 |year= 2004 |pmid= 15158914 |doi= 10.1016/j.bbadis.2004.01.008 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Suzuki A, Hirata M, Kamimura K, ''et al.'' |title=aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1425-35 |year= 2004 |pmid= 15324659 |doi= 10.1016/j.cub.2004.08.021 }}
*{{cite journal  | author=Cohen D, Rodriguez-Boulan E, Müsch A |title=Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 38 |pages= 13792-7 |year= 2004 |pmid= 15365179 |doi= 10.1073/pnas.0403684101 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hazarika P, McCarty MF, Prieto VG, ''et al.'' |title=Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. |journal=Cancer Res. |volume=64 |issue= 20 |pages= 7361-9 |year= 2004 |pmid= 15492257 |doi= 10.1158/0008-5472.CAN-04-0823 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]

Latest revision as of 01:55, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

n/a

n/a

UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.[1][2][3]

Function

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.[3]

Interactions

MARK2 has been shown to interact with AKT1.[4]

References

  1. ↑ Espinosa L, Navarro E (Oct 1998). "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing". Cytogenet Cell Genet. 81 (3–4): 278–82. doi:10.1159/000015046. PMID 9730619.
  2. ↑ Navarro E (Oct 1999). "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search". Cytogenet Cell Genet. 86 (1): 66–7. doi:10.1159/000015413. PMID 10516437.
  3. ↑ 3.0 3.1 "Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2".
  4. ↑ Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L (Mar 2008). "Akt and CHIP coregulate tau degradation through coordinated interactions". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3622–7. doi:10.1073/pnas.0709180105. PMC 2265134. PMID 18292230.

Further reading

  • Courseaux A, Fernandes M, Grosgeorge J, Inglis J, Raynaud SD, Gaudray P (1995). "Human EMK1 is located on 11q12-q13, close to COX8 and FTH1". Mamm. Genome. 6 (4): 311–2. doi:10.1007/BF00352433. PMID 7613050.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Courseaux A, Grosgeorge J, Gaudray P, Pannett AA, Forbes SA, Williamson C, Bassett D, Thakker RV, Teh BT, Farnebo F, Shepherd J, Skogseid B, Larsson C, Giraud S, Zhang CX, Salandre J, Calender A (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics. 37 (3): 354–65. doi:10.1006/geno.1996.0570. PMID 8938448.
  • Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT (2001). "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling". Nat. Cell Biol. 3 (7): 628–36. doi:10.1038/35083016. PMID 11433294.
  • Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  • Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
  • Hueso M, Beltran V, Moreso F, Ciriero E, Fulladosa X, Grinyó JM, Serón D, Navarro E (2004). "Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients". Biochim. Biophys. Acta. 1689 (1): 58–65. doi:10.1016/j.bbadis.2004.01.008. PMID 15158914.
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