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{{Infobox_gene}}
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'''Beta-centractin''' is a [[protein]] that in [[human]]s is encoded by the ''ACTR1B'' [[gene]].<ref name="pmid7696711">{{cite journal | vauthors = Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI | title = Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins | journal = Mol Biol Cell | volume = 5 | issue = 12 | pages = 1301–10 |date=May 1995 | pmid = 7696711 | pmc = 301159 | doi =  10.1091/mbc.5.12.1301}}</ref><ref name="pmid10343100">{{cite journal | vauthors = Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI | title = Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization | journal = Cytogenet Cell Genet | volume = 84 | issue = 1–2 | pages = 48–9 |date=Jun 1999 | pmid = 10343100 | pmc = | doi =10.1159/000015211 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
| HGNCid = 168
| Symbol = ACTR1B
| AltSymbols =; ARP1
| OMIM = 605144
| ECnumber = 
| Homologene = 101541
| MGIid = 1917446
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
  | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005869 |text = dynactin complex}}
| Process = {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10120
    | Hs_Ensembl = ENSG00000115073
    | Hs_RefseqProtein = NP_005726
    | Hs_RefseqmRNA = NM_005735
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 97638863
    | Hs_GenLoc_end = 97646815
    | Hs_Uniprot = P42025
    | Mm_EntrezGene = 226977
    | Mm_Ensembl = ENSMUSG00000037351
    | Mm_RefseqmRNA =146107
    | Mm_RefseqProtein =666219
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 36756047
    | Mm_GenLoc_end = 36766769
    | Mm_Uniprot = Q8R5C5
  }}
}}
'''ARP1 actin-related protein 1 homolog B, centractin beta (yeast)''', also known as '''ACTR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =
| summary_text = This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.<ref name="entrez">{{cite web | title = Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120| accessdate = }}</ref>
| summary_text = This gene encodes a 42.3 [[Atomic mass unit|kD]] subunit of [[dynactin]], a [[macromolecular]] complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both [[microtubules]] and [[cytoplasmic dynein]]. It is involved in a diverse array of [[cell (biology)|cell]]ular functions, including [[Endoplasmic reticulum|ER]]-to-[[Golgi apparatus|Golgi]] transport, the [[centripetal]] movement of [[lysosomes]] and [[endosomes]], [[spindle apparatus|spindle]] formation, [[chromosome]] movement, [[Cell nucleus|nuclear positioning]], and [[axonogenesis]]. This subunit, like [[ACTR1A]], is an actin-related protein. These two proteins are of equal length and share 90% [[amino acid]] identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist}}
{{reflist}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB_Further reading
| citations =  
| citations =
*{{cite journal  | author=Clark SW, Meyer DI |title=Centractin is an actin homologue associated with the centrosome. |journal=Nature |volume=359 |issue= 6392 |pages= 246-50 |year= 1992 |pmid= 1356230 |doi= 10.1038/359246a0 }}
*{{cite journal  | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
*{{cite journal  | author=Lees-Miller JP, Helfman DM, Schroer TA |title=A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. |journal=Nature |volume=359 |issue= 6392 |pages= 244-6 |year= 1992 |pmid= 1528266 |doi= 10.1038/359244a0 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Schafer DA, Gill SR, Cooper JA, ''et al.'' |title=Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin. |journal=J. Cell Biol. |volume=126 |issue= 2 |pages= 403-12 |year= 1994 |pmid= 7518465 |doi=  }}
*{{cite journal  | vauthors=Eckley DM, Schroer TA |title=Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1 |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2645–54 |year= 2004 |pmid= 12857853 |doi= 10.1091/mbc.E03-01-0049 | pmc=165665 }}
*{{cite journal  | author=Clark SW, Staub O, Clark IB, ''et al.'' |title=Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. |journal=Mol. Biol. Cell |volume=5 |issue= 12 |pages= 1301-10 |year= 1995 |pmid= 7696711 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Waterman-Storer CM, Karki S, Holzbaur EL |title=The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1634-8 |year= 1995 |pmid= 7878030 |doi= }}
*{{cite journal  | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
*{{cite journal  | author=Holleran EA, Tokito MK, Karki S, Holzbaur EL |title=Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. |journal=J. Cell Biol. |volume=135 |issue= 6 Pt 2 |pages= 1815-29 |year= 1997 |pmid= 8991093 |doi=  }}
*{{cite journal  | vauthors=Adams MD, Dubnick M, Kerlavage AR |title=Sequence identification of 2,375 human brain genes |journal=Nature |volume=355 |issue= 6361 |pages= 632–4 |year= 1992 |pmid= 1538749 |doi= 10.1038/355632a0 |display-authors=etal}}
*{{cite journal | author=Faulkner NE, Vig B, Echeverri CJ, ''et al.'' |title=Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres. |journal=Hum. Mol. Genet. |volume=7 |issue= 4 |pages= 671-7 |year= 1998 |pmid= 9499420 |doi=  }}
*{{cite journal  | author=Bingham JB, Schroer TA |title=Self-regulated polymerization of the actin-related protein Arp1. |journal=Curr. Biol. |volume=9 |issue= 4 |pages= 223-6 |year= 1999 |pmid= 10074429 |doi=  }}
*{{cite journal  | author=Heimann K, Percival JM, Weinberger R, ''et al.'' |title=Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10743-50 |year= 1999 |pmid= 10196146 |doi=  }}
*{{cite journal  | author=Saffery R, Irvine DV, Griffiths B, ''et al.'' |title=Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins. |journal=Hum. Mol. Genet. |volume=9 |issue= 2 |pages= 175-85 |year= 2000 |pmid= 10607828 |doi=  }}
*{{cite journal  | author=Fouquet J, Kann M, Souès S, Melki R |title=ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. |journal=J. Cell. Sci. |volume=113 ( Pt 5) |issue=  |pages= 877-86 |year= 2000 |pmid= 10671377 |doi=  }}
*{{cite journal  | author=Karki S, Tokito MK, Holzbaur EL |title=A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 4834-9 |year= 2000 |pmid= 10671518 |doi=  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Holleran EA, Ligon LA, Tokito M, ''et al.'' |title=beta III spectrin binds to the Arp1 subunit of dynactin. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36598-605 |year= 2001 |pmid= 11461920 |doi= 10.1074/jbc.M104838200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Carew JA, Jackson AA, Bauer KA |title=ARP1 interacts with the 5' flanking region of the coagulation factor VII gene. |journal=J. Thromb. Haemost. |volume=1 |issue= 6 |pages= 1220-7 |year= 2004 |pmid= 12871323 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|ACTR1B}}
* {{UCSC gene details|ACTR1B}}
 
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{{DEFAULTSORT:Actr1b}}
[[Category:Human proteins]]
 
 
{{gene-2-stub}}

Latest revision as of 17:46, 29 August 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.[1][2][3]

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[3]

References

  1. ↑ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711.
  2. ↑ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100.
  3. ↑ 3.0 3.1 "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=ACTR1B&oldid=1412519"