Uveal melanoma staging: Difference between revisions
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| style="text-align: center; padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | | style="text-align: center; padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | ||
:T4e | :T4e | ||
| style="padding: 5px 5px; background: #F5F5F5;" |The tumor is growing outside the eyeball with the part of the tumor that is outside the eyeball greater than 5millimeters across. The tumor can be any size | | style="padding: 5px 5px; background: #F5F5F5;" |The tumor is growing outside the eyeball with the part of the tumor that is outside the eyeball greater than 5millimeters across. The tumor can be any size | ||
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! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Nodal Mass}} | ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Nodal Mass}} | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:NX | :NX | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Lymph node cannot be assessed | | style="padding: 5px 5px; background: #F5F5F5;" |Lymph node cannot be assessed | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:N1 | :N1 | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Cancer has not been spread to nearby lymph nodes | | style="padding: 5px 5px; background: #F5F5F5;" |Cancer has not been spread to nearby lymph nodes | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:N2 | :N2 | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Cancer has spread to nearby lymph nodes | | style="padding: 5px 5px; background: #F5F5F5;" |Cancer has spread to nearby lymph nodes | ||
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! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Definition}} | ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Definition}} | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center; padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:M0 | :M0 | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Cancer has not spread to distant parts of the body | | style="padding: 5px 5px; background: #F5F5F5;" |Cancer has not spread to distant parts of the body | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center; padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:M1 | :M1 | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Cancer has spread to distant parts of the body | | style="padding: 5px 5px; background: #F5F5F5;" |Cancer has spread to distant parts of the body | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:M1a | :M1a | ||
| style="padding: 5px 5px; background: #F5F5F5;" |The largest area of cancer spread is 3 centimeters (a little over an inch) across or smaller | | style="padding: 5px 5px; background: #F5F5F5;" |The largest area of cancer spread is 3 centimeters (a little over an inch) across or smaller | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:M1b | :M1b | ||
| style="padding: 5px 5px; background: #F5F5F5;" |The largest area of cancer spread is between 3.1 and 8 centimeters across (8 centimeters is a little over 3 inches) | | style="padding: 5px 5px; background: #F5F5F5;" |The largest area of cancer spread is between 3.1 and 8 centimeters across (8 centimeters is a little over 3 inches) | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:M1c | :M1c | ||
| style="padding: 5px 5px; background: #F5F5F5;" |The largest area of cancer spread is 8 centimeters or more across | | style="padding: 5px 5px; background: #F5F5F5;" |The largest area of cancer spread is 8 centimeters or more across | ||
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===Anatomic stage or prognostic groups of uveal melanoma=== | ===Anatomic stage or prognostic groups of uveal melanoma=== | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 800px" align=center | {| style="border: 0px; font-size: 90%; margin: 3px; width: 800px" align=center | ||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''M'''}} | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''M'''}} | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:Stage 1 | :Stage 1 | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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*M0 | *M0 | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:Stage IIA | :Stage IIA | ||
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*M0 | *M0 | ||
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:Stage IIB | :Stage IIB | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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*M0 | *M0 | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:Stage IIIA | :Stage IIIA | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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*M0 | *M0 | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:Stage IIIB | :Stage IIIB | ||
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*M0 | *M0 | ||
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:Stage III C | :Stage III C | ||
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*M0 | *M0 | ||
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| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | | style="text-align: center;padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | ||
: Stage IV | : Stage IV | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Ophthalmology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Ophthalmology]] | [[Category:Ophthalmology]] |
Latest revision as of 17:35, 27 November 2017
Uveal melanoma Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Uveal melanoma staging On the Web |
American Roentgen Ray Society Images of Uveal melanoma staging |
Risk calculators and risk factors for Uveal melanoma staging |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
According to the American Joint Committee on Cancer, there are four stages of uveal melanoma based on the tumor size, spread to nearby lymph nodes, and metastasis. Each stage is assigned a number 0 through 4 that indicate increasing severity and letters T, N, and M that designate the tumor size, spread to nearby lymph nodes, and metastasis respectively.[1]
Staging
The most common staging system used for melanoma of the uveal tract was developed by the American Joint Committee on Cancer (AJCC). The TNM system is based on three key pieces of information:[1]
- T describes the size of the primary tumor and/or whether it has invaded nearby structures
- N describes whether the cancer has spread to nearby (regional) lymph nodes
- M indicates whether the cancer has metastasized (spread) to other parts of the body (The most common site of eye melanoma spread is the liver)
- Numbers or letters appear after T, N and M to provide more details about each of these factors:
- The numbers 0 through 4 indicate increasing severity
- The letter X means "cannot be assessed" because the information is not available.
- The N and M categories are the same for all uveal melanomas (iris, ciliary body or choroid).
- The T categories, however, are different for these locations.
T categories for iris melanoma
Stage | Tumor location |
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The main (primary) tumor cannot be assessed; information not known |
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No evidence of a primary tumor |
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Tumor is only in the iris |
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The tumor is only in the iris and touches 1/4 or less of the iris |
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The tumor is only in the iris and touches more than 1/4 of the iris |
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The tumor is only in the iris and is causing an increase in the eye pressure (glaucoma) |
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Tumor has grown into the ciliary body or choroid (or both) |
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Tumor has grown into the ciliary body and/or choroid and is causing glaucoma |
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Tumor has grown into the ciliary body and/or choroid and into the sclera |
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Tumor has grown into the ciliary body and/or choroid and into the sclera and is causing glaucoma |
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Tumor extends outside the eyeball |
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The part of the tumor that is outside the eyeball is 5 millimeters (about 1/5 of an inch) or less across in size |
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The part of the tumor that is outside the eyeball is greater than 5 millimeters (about 1/5 of an inch) in size |
T categories for ciliary body and choroidal melanoma
Stage | Tumor location |
---|---|
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The main (primary) tumor cannot be assessed; information not known |
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No evidence of a primary tumor |
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Tumor size is either:
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The tumor is T1 in size and is not growing into the ciliary body or growing outside the eyeball |
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The tumor is T1 in size and is growing into the ciliary body |
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The tumor is T1 in size and is not growing into the ciliary body but is growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size |
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The tumor is T1 in size and is growing into the ciliary body. It is also growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size |
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Tumor size is one of the following:
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The tumor is T2 in size and is not growing into the ciliary body or growing outside the eyeball |
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The tumor is T2 in size and is growing into the ciliary body |
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The tumor is T2 in size and is not growing into the ciliary body but is growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size |
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The tumor is T2 in size and is growing into the ciliary body. It is also growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size |
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Tumor size is one of the following:
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The tumor is T3 in size and is not growing into the ciliary body or growing outside the eyeball |
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The tumor is T3 in size and is growing into the ciliary body |
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the tumor is T3 in size and is not growing into the ciliary body but is growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size |
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The tumor is T3 in size and is growing into the ciliary body. It is also growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size. |
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Tumor size is one of the following:
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The tumor is T4 in size and is not growing into the ciliary body or growing outside the eyeball |
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The tumor is T4 in size and is growing into the ciliary body |
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The tumor is T4 in size and is not growing into the ciliary body but is growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size |
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The tumor is T4 in size and is growing into the ciliary body. It is also growing outside of the eyeball. The part of the tumor that is outside the eyeball is 5millimeters (about 1/5 of an inch) or less across in size |
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The tumor is growing outside the eyeball with the part of the tumor that is outside the eyeball greater than 5millimeters across. The tumor can be any size |
N categories for iris, ciliary body and choroidal melanomas
N classification | Nodal Mass |
---|---|
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Lymph node cannot be assessed |
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Cancer has not been spread to nearby lymph nodes |
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Cancer has spread to nearby lymph nodes |
M categories for iris, ciliary body, and choroidal melanomas
M Classification | Definition |
---|---|
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Cancer has not spread to distant parts of the body |
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Cancer has spread to distant parts of the body |
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The largest area of cancer spread is 3 centimeters (a little over an inch) across or smaller |
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The largest area of cancer spread is between 3.1 and 8 centimeters across (8 centimeters is a little over 3 inches) |
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The largest area of cancer spread is 8 centimeters or more across |
Anatomic stage or prognostic groups of uveal melanoma
Stage | T | N | M |
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References
- ↑ 1.0 1.1 Retinoblastoma. National Cancer institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq#section/_100 Accessed on October 21, 2015