Hepatic hemangioma: Difference between revisions

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{{Infobox_Disease |
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  Name          = {{PAGENAME}} |
{{Hepatic hemangioma}}
  Image          = Heptatic hemangioma 005.jpg|
  Caption        = Heptatic hemangioma. <br> [http://www.radswiki.net Image courtesy of RadsWiki]|
  DiseasesDB    = |
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  ICDO          = |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = |
  eMedicineTopic = |
  MeshID        = |
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{{SI}}
{{CMG}}


'''Contributors:'''  [[User:zorkun|Cafer Zorkun]] M.D., PhD.
'''For patient information, click [[Hepatocellular hemangioma (patient information)|here]]'''


{{Editor Help}}
{{CMG}}; {{AE}}  [[User:zorkun|Cafer Zorkun]] M.D., PhD., {{NM}}


==Overview==
{{SK}} Liver hemangioma; Hemangioma of the liver; Cavernous hepatic hemangioma; Typical hepatic hemangioma; Atypical hepatic hemangioma; Giant hepatic hemangioma; Flash filling hepatic hemangioma; Slow fill hepatic hemangioma; Calcified hepatic hemangioma; Hyalinised hepatic hemangioma; Sclerosed hepatic hemangioma; Pedunculated hepatic hemangioma; Cystic hepatic hemangioma; Hepatocyte hemangioma; Hepatocellular hemangioma


* Most common primary liver tumor
==[[Hepatic hemangioma overview|Overview]]==
* Ranges from 0.4-20% of the population
* Arise from the endothelial cells that line the blood vessels and consists of multiple, large vascular channels lined by a single layer of endothelial cells and supported by collagenous walls.
* They are frequently asymptomatic and incidentally discovered at imaging, surgery, or autopsy.
* They may be associated with [[focal nodular hyperplasia]].
* M:F = 1:5
* May be associated with [[Kasabach-Merritt syndrome]]: [[Hemolytic anemia]] and consumptive coagulopathy


==Diagnosis==
==[[Hepatic hemangioma historical perspective|Historical perspective]]==


===Ultrasonography===
==[[Hepatic hemangioma classification|Classification]]==


* Echogenic
==[[Hepatic hemangioma pathophysiology|Pathophysiology]]==
* Homogenous


===Computed Tomography===
==[[Hepatic hemangioma causes|Causes]]==


* Noncontrast: Hypointense to liver
==[[Hepatic hemangioma differential diagnosis|Differentiating Hepatic Hemangioma from other Diseases]]==
* Portal venous enhancement: Peripheral nodular enhancement
* Delayed enhancement: Lesion fills in the contrast


===MRI===
==[[Hepatic hemangioma epidemiology and demographics|Epidemiology and Demographics]]==


* T2 hyperintense
==[[Hepatic hemangioma risk factors|Risk Factors]]==
* Portal venous enhancement: Peripheral nodular enhancement
* Delayed enhancement: Lesion fills in the contrast


===Scintigraphy===
==[[Hepatic hemangioma screening|Screening]]==


* Tc99-labeled red blood cells show decreased activity on early dynamic images and increased activity on delayed images (i.e. 1-2 hours).
==[[Hepatic hemangioma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
* Only sensitive for larger lesions.


==Diagnostic Findings==
==Diagnosis==


[http://www.radswiki.net Images courtesy of RadsWiki]
[[Hepatic hemangioma history and symptoms|History and Symptoms]] | [[Hepatic hemangioma physical examination|Physical Examination]] | [[Hepatic hemangioma laboratory findings|Laboratory Findings]] | [[Hepatic hemangioma CT|CT]] | [[Hepatic hemangioma MRI|MRI]] | [[Hepatic hemangioma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Hepatic hemangioma other imaging findings|Other Imaging Findings]] | [[Hepatic hemangioma other diagnostic studies|Other Diagnostic Studies]]


<gallery perRow="3">
==Treatment==
Image:Heptatic hemangioma 001.jpg|T2 FrFSE
Image:Heptatic hemangioma 002.jpg|T1
Image:Heptatic hemangioma 003.jpg|T1 post Gad
Image:Heptatic hemangioma 004.jpg|T1 post Gad
Image:Heptatic hemangioma 005.jpg|T1 post Gad
Image:Heptatic hemangioma 006.jpg|T1 post Gad coronal
</gallery>


==References & Additional Resources==
[[Hepatic hemangioma medical therapy|Medical Therapy]] | [[Hepatic hemangioma surgery|Surgery]] | [[Hepatic hemangioma prevention|Prevention]] | [[Hepatic hemangioma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Hepatic hemangioma future or investigational therapies|Future or Investigational Therapies]]
{{Refbegin|2}}
*Moser C, Hany A, Spiegel R. [Familial giant hemangiomas of the liver. Study of a family and review of the literature]. Praxis (Bern 1994). Apr 1 1998;87(14):461-8.


*Takahashi T, Kuwao S, Katagiri H, et al. Multiple liver hemangiomas enlargement during long-term steroid therapy for myasthenia gravis. Dig Dis Sci. Jul 1998;43(7):1553-61. 
==Case Studies==
[[Hepatic hemangioma case study one|Case #1]]


*Giannitrapani L, Soresi M, La Spada E, et al. Sex hormones and risk of liver tumor. Ann N Y Acad Sci. Nov 2006;1089:228-36. 
==Related Chapters==


*Glinkova V, Shevah O, Boaz M, et al. Hepatic haemangiomas: possible association with female sex hormones. Gut. Sep 2004;53(9):1352-5. 
*[[Infantile hemangioendothelioma]]


*Spitzer D, Krainz R, Graf AH, et al. Pregnancy after ovarian stimulation and intrauterine insemination in a woman with cavernous macrohemangioma of the liver. A case report. J Reprod Med. Dec 1997;42(12):809-12. 
{{Gastroenterology}}
 
*Dreyfus M, Baldauf JJ, Dadoun K, et al. Prenatal diagnosis of hepatic hemangioma. Fetal Diagn Ther. Jan-Feb 1996;11(1):57-60. 
 
*Suzuki T, Tsuchiya N, Ito K. Multiple cavernous hemangiomas of the liver in patients with systemic lupus erythematosus. J Rheumatol. Apr 1997;24(4):810-1. 
 
*Goodman Z. Benign tumors of the liver. In: Okuda K, Ishak KG. Neoplasms of the liver. Tokyo: Springer-Verlag; 1987:105-125.
 
*Mikami T, Hirata K, Oikawa I, et al. Hemobilia caused by a giant benign hemangioma of the liver: report of a case. Surg Today. 1998;28(9):948-52. 
 
*Lee CW, Chung YH, Lee GC, et al. A case of giant hemangioma of the liver presenting with fever of unknown origin. J Korean Med Sci. Apr 1994;9(2):200-4. 
 
*Pol B, Disdier P, Le Treut YP, et al. Inflammatory process complicating giant hemangioma of the liver: report of three cases. Liver Transpl Surg. May 1998;4(3):204-7. 
 
*Huang SA, Tu HM, Harney JW, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med. Jul 20 2000;343(3):185-9. 
 
*Lorette G, Georgesco G, Sirinelli D, et al. [Cutaneous immature hemangioma and hepatic angioma: there is no frequent association]. Ann Dermatol Venereol. 1996;123(12):789-90. 
 
*Brannigan M, Burns PN, Wilson SR. Blood flow patterns in focal liver lesions at microbubble-enhanced US. Radiographics. Jul-Aug 2004;24(4):921-35. 
 
*Dietrich CF, Mertens JC, Braden B, et al. Contrast-enhanced ultrasound of histologically proven liver hemangiomas. Hepatology. May 2007;45(5):1139-45. 
 
*von Herbay A, Vogt C, Willers R, et al. Real-time imaging with the sonographic contrast agent SonoVue: differentiation between benign and malignant hepatic lesions. J Ultrasound Med. Dec 2004;23(12):1557-68. 
 
*Farges O, Daradkeh S, Bismuth H. Cavernous hemangiomas of the liver: are there any indications for resection?. World J Surg. Jan-Feb 1995;19(1):19-24. 
 
*Obata S, Matsunaga N, Hayashi K, et al. Fluid-fluid levels in giant cavernous hemangioma of the liver: CT and MRI demonstration. Abdom Imaging. Nov-Dec 1998;23(6):600-2. 
 
*Kinnard MF, Alavi A, Rubin RA, et al. Nuclear imaging of solid hepatic masses. Semin Roentgenol. Oct 1995;30(4):375-95. 
 
*Krause T, Hauenstein K, Studier-Fischer B, et al. Improved evaluation of technetium-99m-red blood cell SPECT in hemangioma of the liver. J Nucl Med. Mar 1993;34(3):375-80. 
 
*Tsai CC, Yen TC, Tzen KY. Pedunculated giant liver hemangioma mimicking a hypervascular gastric tumor on Tc-99m RBC SPECT. Clin Nucl Med. Feb 1999;24(2):132-3. 
 
*De Franco A, Monteforte MG, Maresca G, et al. [Integrated diagnosis of liver angioma: comparison of Doppler color ultrasonography, computerized tomography, and magnetic resonance]. Radiol Med. Jan-Feb 1997;93(1-2):87-94. 
 
*Heilo A, Stenwig AE. Liver hemangioma: US-guided 18-gauge core-needle biopsy. Radiology. Sep 1997;204(3):719-22. 
 
*Bruix J, Sherman M, Llovet JM, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. Sep 2001;35(3):421-30. 
 
*Craig JR, Peters RL, Edmondson HA. Tumors of the Liver and Intrahepatic Bile Ducts, 2nd series, fascicle 26. Washington, DC. Armed Forces Institute of Pathology. 1989;191.
 
*Ishak KG, Markin RS. Liver. In: Damjanov I, Linder J, eds. Anderson's Pathology. 10th ed. Mosby: St. Louis, Mo; 1996:1834.
 
*Gibney RG, Hendin AP, Cooperberg PL. Sonographically detected hepatic hemangiomas: absence of change over time. AJR Am J Roentgenol. Nov 1987;149(5):953-7. 


*Corigliano N, Mercantini P, Amodio PM, et al. Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case. Surg Today. 2003;33(6):459-63. 
*Arnoletti JP, Brodsky J. Surgical treatment of benign hepatic mass lesions. Am Surg. May 1999;65(5):431-3. 
*Srivastava DN, Gandhi D, Seith A, et al. Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study. Abdom Imaging. Sep-Oct 2001;26(5):510-4. 
*Zeng Q, Li Y, Chen Y, et al. Gigantic cavernous hemangioma of the liver treated by intra-arterial embolization with pingyangmycin-lipiodol emulsion: a multi-center study. Cardiovasc Intervent Radiol. Sep-Oct 2004;27(5):481-5. 
*Rokitansky AM, Jakl RJ, Gopfrich H, et al. Special compression sutures: a new surgical technique to achieve a quick decrease in shunt volume caused by diffuse hemangiomatosis of the liver. Pediatr Surg Int. Nov 1998;14(1-2):119-21. 
*Tak WY, Park SY, Jeon SW, et al. Ultrasonography-guided percutaneous radiofrequency ablation for treatment of a huge symptomatic hepatic cavernous hemangioma. J Clin Gastroenterol. Feb 2006;40(2):167-70. 
*Fan RF, Chai FL, He GX, et al. Laparoscopic radiofrequency ablation of hepatic cavernous hemangioma. A preliminary experience with 27 patients. Surg Endosc. Feb 2006;20(2):281-5. 
*Biswal BM, Sandhu M, Lal P, et al. Role of radiotherapy in cavernous hemangioma liver. Indian J Gastroenterol. Jul 1995;14(3):95-8. 
*Tepetes K, Selby R, Webb M, et al. Orthotopic liver transplantation for benign hepatic neoplasms. Arch Surg. Feb 1995;130(2):153-6. 
{{refend}}
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Latest revision as of 01:56, 27 November 2017

Hepatic hemangioma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hepatic Hemangioma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun M.D., PhD., Nawal Muazam M.D.[2]

Synonyms and keywords: Liver hemangioma; Hemangioma of the liver; Cavernous hepatic hemangioma; Typical hepatic hemangioma; Atypical hepatic hemangioma; Giant hepatic hemangioma; Flash filling hepatic hemangioma; Slow fill hepatic hemangioma; Calcified hepatic hemangioma; Hyalinised hepatic hemangioma; Sclerosed hepatic hemangioma; Pedunculated hepatic hemangioma; Cystic hepatic hemangioma; Hepatocyte hemangioma; Hepatocellular hemangioma

Overview

Historical perspective

Classification

Pathophysiology

Causes

Differentiating Hepatic Hemangioma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters

Template:Gastroenterology


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