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==Overview==
==Overview==
Trench fever is an intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by BARTONELLA QUINTANA and transmitted by the human louse."
Trench fever is an intermittent fever characterized by intervals of [[chills]], [[fever]], and [[splenomegaly]] each of which may last as long as 40 hours. It is caused by ''[[bartonella quintana]]'' and transmitted by the human louse.
 
==Historical Perspective==
It infected the armies in Flanders, France, Poland, Galicia, Italy, Slonika, Macedonia, Mesopotamia, and Egypt in World War I<ref name="Justina">{{cite book|title=Silent Enemies: The Story of the Diseases of War and Their Control|author=Justina Hamilton Hill|date=1942|publisher=G. P. Putnam's Sons}}</ref><ref name="Hagan">{{cite book|title=Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals|author=Francis Timoney, William Arthur Hagan|publisher=Cornell University Press|date=1973}}</ref> (including J.R.R. Tolkien<ref name="Tolkien">{{cite book|title=Tolkien and the Great War: The Threshold of Middle-earth|author=John Garth|publisher=HarperCollins Publishers|date=2003}}</ref>) and the German army in Russia during World War II.<ref name="Hagan"/> From 1915-1918 between one-fifth and one-third of all British troops reported ill were caused by Trench Fever while about one-fifth of ill German and Austrian troops had the disease.<ref name="Justina"/>
 
== Pathophysiology==
''Rickettsia quintana'' is transmitted by the by contamination of a [[skin]] [[abrasion]] or of a louse-bite wound with the faeces of an infected [[body louse]](''[[Pediculus humanus corporis]]''), there has also been reports of an infected louse bite passing on the [[infection]].<ref name="Hagan"/><ref name="Tropical">{{cite book|title=The Diagnostics and treatment of tropical diseases|author=Edward Rhodes Stitt|publisher=P. Blakiston's Son & Co.|date=1922}}</ref>
 
==Causes==
The disease is caused by the organism ''Rickettsia quintana'', found in the stomach walls of the [[body louse]].<ref name="Hagan"/> Rickettsia is closely related to the more dangerous microbes of [[Rocky Mountain spotted fever]] and [[typhus]]<ref name="Justina"/>
==Epidemiology and Demographics==
 
Outbreaks have been documented, for example, in Seattle, Washington and Baltimore, Maryland in the United States among injection drug users and in Marseille, France and Burundi.
 
==Natural History, Complications and Prognosis==
 
Lethal cases are rare, but in a few cases the persistent [[fever]] might lead to [[heart failure]]. After effects may include [[neurasthenia]], cardiac disturbances and [[myalgia]].
 
==Diagnosis==
 
===History and Symptoms===
 
The disease is classically a five-day [[fever]] of the relapsing type, rarely with a continuous course instead.  [[Latent period]] is relatively long (about two weeks). The onset of symptoms is usually sudden with high [[fever]], severe [[headache]], [[pain]] on moving the eyeballs, soreness of the [[muscle]]s of the legs and back, and frequently [[hyperaesthesia]] of the shins. The initial fever is usually followed in a few days by a single short rise but there may be many relapses between periods without fever.The most constant symptom is pain in the legs. Recovery takes a month or more.
 
===Laboratory Findings===
[[Serological]] testing (e.g., the [[Weil-Felix test]]) is typically used to obtain a  definitive [[diagnosis]].  Most serological tests would succeed only after a certain period of time past the symptom onset (usually a week).
 
==Treatment==
 
===Medical Therapy===
[[Tetracycline]]-group antibiotics ([[doxycycline]], [[tetracycline]]) are commonly used. [[Chloramphenicol]] is an alternative medication  recommended under circumstances that render tetracycline derivates usage undesirable (such as severe liver malfunction, kidney deficiency, in children under  nine years and pregnant women). The drug is administered for seven to ten days.
 
The treatment for bacillary angiomatosis is [[erythromycin]] given for three to four months.<ref>{{cite journal | author=Beghari S, Rolain J-M, Grau GE, ''et al.'' | title=Antiangiogenic effect of erythromycin: an in vitro model of ''Bartonella quintana'' infection | journal=J Infect Dis | year=2006 | volume=193 |issue=3 | pages=380&ndash;6 }}</ref>
 
== References ==
== References ==
<references/>
<references/>
[[Category:Bacterial diseases]]
[[Category:Bacterial diseases]]
[[Category:Infectious disease]]
 
[[Category:Disease]]
[[Category:Disease]]
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Latest revision as of 19:00, 18 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Trench fever is an intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by bartonella quintana and transmitted by the human louse.

Historical Perspective

It infected the armies in Flanders, France, Poland, Galicia, Italy, Slonika, Macedonia, Mesopotamia, and Egypt in World War I[1][2] (including J.R.R. Tolkien[3]) and the German army in Russia during World War II.[2] From 1915-1918 between one-fifth and one-third of all British troops reported ill were caused by Trench Fever while about one-fifth of ill German and Austrian troops had the disease.[1]

Pathophysiology

Rickettsia quintana is transmitted by the by contamination of a skin abrasion or of a louse-bite wound with the faeces of an infected body louse(Pediculus humanus corporis), there has also been reports of an infected louse bite passing on the infection.[2][4]

Causes

The disease is caused by the organism Rickettsia quintana, found in the stomach walls of the body louse.[2] Rickettsia is closely related to the more dangerous microbes of Rocky Mountain spotted fever and typhus[1]

Epidemiology and Demographics

Outbreaks have been documented, for example, in Seattle, Washington and Baltimore, Maryland in the United States among injection drug users and in Marseille, France and Burundi.

Natural History, Complications and Prognosis

Lethal cases are rare, but in a few cases the persistent fever might lead to heart failure. After effects may include neurasthenia, cardiac disturbances and myalgia.

Diagnosis

History and Symptoms

The disease is classically a five-day fever of the relapsing type, rarely with a continuous course instead. Latent period is relatively long (about two weeks). The onset of symptoms is usually sudden with high fever, severe headache, pain on moving the eyeballs, soreness of the muscles of the legs and back, and frequently hyperaesthesia of the shins. The initial fever is usually followed in a few days by a single short rise but there may be many relapses between periods without fever.The most constant symptom is pain in the legs. Recovery takes a month or more.

Laboratory Findings

Serological testing (e.g., the Weil-Felix test) is typically used to obtain a definitive diagnosis. Most serological tests would succeed only after a certain period of time past the symptom onset (usually a week).

Treatment

Medical Therapy

Tetracycline-group antibiotics (doxycycline, tetracycline) are commonly used. Chloramphenicol is an alternative medication recommended under circumstances that render tetracycline derivates usage undesirable (such as severe liver malfunction, kidney deficiency, in children under nine years and pregnant women). The drug is administered for seven to ten days.

The treatment for bacillary angiomatosis is erythromycin given for three to four months.[5]

References

  1. 1.0 1.1 1.2 Justina Hamilton Hill (1942). Silent Enemies: The Story of the Diseases of War and Their Control. G. P. Putnam's Sons.
  2. 2.0 2.1 2.2 2.3 Francis Timoney, William Arthur Hagan (1973). Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals. Cornell University Press.
  3. John Garth (2003). Tolkien and the Great War: The Threshold of Middle-earth. HarperCollins Publishers.
  4. Edward Rhodes Stitt (1922). The Diagnostics and treatment of tropical diseases. P. Blakiston's Son & Co.
  5. Beghari S, Rolain J-M, Grau GE; et al. (2006). "Antiangiogenic effect of erythromycin: an in vitro model of Bartonella quintana infection". J Infect Dis. 193 (3): 380&ndash, 6.

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