Pott's disease pathophysiology: Difference between revisions

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{{Pott's disease}}
{{Pott's disease}}
{{CMG}}; {{AE}} {{HP}}
{{CMG}}; {{AE}} {{HP}}; {{AKI}}


==Overview==
==Overview==
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*The common lesions of [[vertebra]] in [[Pott's disease|spinal tuberculosis]] include [[paradiskal]], [[anterior]], and [[central]] [[lesions]].
*The common lesions of [[vertebra]] in [[Pott's disease|spinal tuberculosis]] include [[paradiskal]], [[anterior]], and [[central]] [[lesions]].
*The most commonly involved sites are the [[upper]] [[lumbar]] and the lower [[thoracic vertebrae]], the body of the [[vertebra]] is typically affected than the arch.<ref name="pmid26609247">{{cite journal| author=Ekinci S, Tatar O, Akpancar S, Bilgic S, Ersen O| title=Spinal Tuberculosis. | journal=J Exp Neurosci | year= 2015 | volume= 9 | issue=  | pages= 89-90 | pmid=26609247 | doi=10.4137/JEN.S32842 | pmc=4644140 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26609247  }} </ref>
*The most commonly involved sites are the [[upper]] [[lumbar]] and the lower [[thoracic vertebrae]], the body of the [[vertebra]] is typically affected than the arch.<ref name="pmid26609247">{{cite journal| author=Ekinci S, Tatar O, Akpancar S, Bilgic S, Ersen O| title=Spinal Tuberculosis. | journal=J Exp Neurosci | year= 2015 | volume= 9 | issue=  | pages= 89-90 | pmid=26609247 | doi=10.4137/JEN.S32842 | pmc=4644140 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26609247  }} </ref>
*The [[infection]] results in the [[destruction]] of the [[intervertebral]] [[disc space]] and the adjacent [[vertebral bodies]], [[collapse]] of the [[spinal]] elements, and [[anterior]] [[wedging]] resulting in a characteristic [[angulation]] and [[gibbus]] formation. [[Gibbus]] is a [[palpable]] [[deformity]] due to the involvement of [[multiple]] [[vertebra]].<ref name="pmid26609247">{{cite journal| author=Ekinci S, Tatar O, Akpancar S, Bilgic S, Ersen O| title=Spinal Tuberculosis. | journal=J Exp Neurosci | year= 2015 | volume= 9 | issue=  | pages= 89-90 | pmid=26609247 | doi=10.4137/JEN.S32842 | pmc=4644140 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26609247  }} </ref>
*The [[infection]] results in the [[destruction]] of the [[intervertebral]] [[disc space]] and the adjacent [[vertebral bodies]], collapse of the [[spinal]] elements, and [[anterior]] [[wedging]] resulting in a characteristic [[angulation]] and [[gibbus]] formation. [[Gibbus]] is a [[palpable]] [[deformity]] due to the involvement of [[multiple]] [[vertebra]].<ref name="pmid26609247">{{cite journal| author=Ekinci S, Tatar O, Akpancar S, Bilgic S, Ersen O| title=Spinal Tuberculosis. | journal=J Exp Neurosci | year= 2015 | volume= 9 | issue=  | pages= 89-90 | pmid=26609247 | doi=10.4137/JEN.S32842 | pmc=4644140 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26609247  }} </ref>
*The [[destruction]] of the [[disc space]] and the [[wedging]] results in [[spinal]] [[deformity]]. [[Kyphosis]] is more prominent if the [[disc]] and [[bone]] [[destruction]] occurs in the [[thoracic spine]] due to the collapse in the [[anterior spine]]. The [[granuloma]] or the [[abscess]] can cause narrowing of the [[spinal canal]] leading to [[paraplegia]] secondary to [[cord compression]].<ref name="pmid25952174">{{cite journal| author=Kilborn T, Janse van Rensburg P, Candy S| title=Pediatric and adult spinal tuberculosis: imaging and pathophysiology. | journal=Neuroimaging Clin N Am | year= 2015 | volume= 25 | issue= 2 | pages= 209-31 | pmid=25952174 | doi=10.1016/j.nic.2015.01.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25952174  }} </ref>
*The [[destruction]] of the [[disc space]] and the [[wedging]] results in [[spinal]] [[deformity]]. [[Kyphosis]] is more prominent if the [[disc]] and [[bone]] [[destruction]] occurs in the [[thoracic spine]] due to the collapse in the [[anterior spine]]. The [[granuloma]] or the [[abscess]] can cause narrowing of the [[spinal canal]] leading to [[paraplegia]] secondary to [[cord compression]].<ref name="pmid25952174">{{cite journal| author=Kilborn T, Janse van Rensburg P, Candy S| title=Pediatric and adult spinal tuberculosis: imaging and pathophysiology. | journal=Neuroimaging Clin N Am | year= 2015 | volume= 25 | issue= 2 | pages= 209-31 | pmid=25952174 | doi=10.1016/j.nic.2015.01.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25952174  }} </ref>
*In patients with [[anterior]] [[Pott's disease|spinal tuberculosis]], [[motor fibers]] are [[compressed]] first affecting the [[motor function]]. This is because the [[motor fibres]] are [[anteriorly]] placed in relation to the [[sensory fibers]] in [[spinal cord]].
*In patients with [[anterior]] [[Pott's disease|spinal tuberculosis]], [[motor fibers]] are [[compressed]] first affecting the [[motor function]]. This is because the [[motor fibres]] are [[anteriorly]] placed in relation to the [[sensory fibers]] in [[spinal cord]].
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[[Category:Vertebral column disorders]]
[[Category:Vertebral column disorders]]
[[Category:Tuberculosis]]
[[Category:Tuberculosis]]
[[Category:Infectious disease]]
 
[[Category:Disease]]
[[Category:Disease]]


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Latest revision as of 18:47, 18 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hardik Patel, M.D.; Aravind Kuchkuntla, M.B.B.S[2]

Overview

Pott's disease occurs usually due to hematogenous spread of tuberculous infection from an extraspinal source. Pott's disease usually involves more than one vertebra and manifests as a combination of osteomyelitis and arthritis.

Pathophysiology

Source of infection

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References

  1. Rajasekaran S, Kanna RM, Shetty AP (2014). "Pathophysiology and Treatment of Spinal Tuberculosis". JBJS Rev. 2 (9). doi:10.2106/JBJS.RVW.M.00130. PMID 27490153.
  2. Cooper C, Fellner R, Heubi O, Maixner F, Zink A, Lösch S (2016). "Tuberculosis in early medieval Switzerland--osteological and molecular evidence". Swiss Med Wkly. 146: w14269. doi:10.4414/smw.2016.14269. PMID 26826871.
  3. Batirel A, Erdem H, Sengoz G, Pehlivanoglu F, Ramosaco E, Gülsün S; et al. (2015). "The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study". Clin Microbiol Infect. 21 (11): 1008.e9–1008.e18. doi:10.1016/j.cmi.2015.07.013. PMID 26232534.
  4. Formica M, Cavagnaro L, Formica C (2015). "Pott disease". Spine J. 15 (3): 556–7. doi:10.1016/j.spinee.2014.11.006. PMID 25459741.
  5. Kim JH, Kim SH, Choi JI, Lim DJ (2014). "Atypical noncontiguous multiple spinal tuberculosis: a case report". Korean J Spine. 11 (2): 77–80. doi:10.14245/kjs.2014.11.2.77. PMC 4124923. PMID 25110488.
  6. 6.0 6.1 6.2 Ekinci S, Tatar O, Akpancar S, Bilgic S, Ersen O (2015). "Spinal Tuberculosis". J Exp Neurosci. 9: 89–90. doi:10.4137/JEN.S32842. PMC 4644140. PMID 26609247.
  7. 7.0 7.1 Kilborn T, Janse van Rensburg P, Candy S (2015). "Pediatric and adult spinal tuberculosis: imaging and pathophysiology". Neuroimaging Clin N Am. 25 (2): 209–31. doi:10.1016/j.nic.2015.01.002. PMID 25952174.
  8. Tin SS, Wiwanitkit V (2014). "Noncontiguous multiple spinal tuberculosis". Korean J Spine. 11 (4): 259. doi:10.14245/kjs.2014.11.4.259. PMC 4303286. PMID 25620992.
  9. Shim HK, Cho HL, Lee SH (2014). "Spinal tuberculosis at the posterior element of spinal column: case report". Clin Neurol Neurosurg. 124: 146–50. doi:10.1016/j.clineuro.2014.05.021. PMID 25051165.
  10. Zhang HQ, Deng A, Guo CF, Wang YX, Chen LQ, Wang YF; et al. (2010). "Association between FokI polymorphism in vitamin D receptor gene and susceptibility to spinal tuberculosis in Chinese Han population". Arch Med Res. 41 (1): 46–9. doi:10.1016/j.arcmed.2009.12.004. PMID 20430254.
  11. Panwar A, Garg RK, Malhotra HS, Jain A, Singh AK, Prakash S; et al. (2016). "25-Hydroxy Vitamin D, Vitamin D Receptor and Toll-like Receptor 2 Polymorphisms in Spinal Tuberculosis: A Case-Control Study". Medicine (Baltimore). 95 (17): e3418. doi:10.1097/MD.0000000000003418. PMC 4998689. PMID 27124026.

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