Sandbox:risk: Difference between revisions

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{{familytree/start |summary=PE diagnosis Algorithm.}}
{{familytree/start |summary=PE diagnosis Algorithm.}}
{{familytree | | | | | | | | | |,|-| A01 | | | | |A01=
{{familytree | | | | | | | | |,|-| A01 | | | | |A01=
<div style="width: 20em; padding:0em;text-align:left">
<div style="width: 20em; padding:0em;text-align:left">
* '''INSS stage 1'''<br>
*'''INNS stage 2A/2B, Stage 3 , Stage 4 or Stage 4S'''<br>
*'''Irrespective of age'''<br>
*'''Irrespective of grade'''<br>
*'''Irrespective of molecular pathway'''</div>}}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | C01 |-|+|-| B01 | | | | |C01=<div style="width: 20em; padding:0em;text-align:center">'''Low risk neuroblastoma patients'''</div>|B01=<div style="width: 20em; padding:0em;text-align:left">
*'''INSS stage 2A/2B (>50% resected)'''<br>
*'''Irrespective of age'''<br>
*'''Irrespective of age'''<br>
*'''Irrespective of grade'''<br>
*'''Irrespective of grade'''<br>
*'''''MYCN'' amplified'''</div>}}
{{familytree | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | |)|-| B01 | | | | ||B01=<div style="width: 20em; padding:0em;text-align:left">
*'''INSS stage 3'''<br>
*'''>547 days of age'''<br>
*'''Unfavorable histology'''<br>
*'''''MYCN'' not amplified'''</div>}}
*'''''MYCN'' not amplified'''</div>}}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | }}
{{familytree | | | | | C01 |-|(| | | | | |C01=<div style="width: 20em; padding:1em;text-align:center">'''Intermediate risk neuroblastoma patients (group 2)'''</div> | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |`|-| C02 | | | | | | |C02=<div style="width: 20em; padding:0em;text-align:left">
{{familytree | | | | | | | | |)|-| C02 | | | | | | |C02=<div style="width: 20em; padding:0em;text-align:left">
*'''INNS stage 4S'''<br>
*'''INNS stage 4'''<br>
*'''<365 days of age'''<br>
*'''365-547 days of age'''<br>
*'''Favorable histology'''<br>
*'''Unfavorable histology'''<br>
*'''DNA index >1'''<br>
*'''DNA index=1'''<br>
*'''''MYCN'' not amplified'''</div>}}
*'''''MYCN'' not amplified'''</div>}}
{{familytree | | | | | | | | |!| | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | |`|-| C02 | | | | | | |C02=<div style="width: 20em; padding:0em;text-align:left">
*'''Symptomatic INNS stage 4'''<br>
*'''>547 days of age'''<br>
*'''Irrespective grade'''<br>
*'''Irrespective ''MYCN'' amplification state'''</div>}}
{{familytree/end}}
{{familytree/end}}
<br>
{{familytree/start |summary=PE diagnosis Algorithm.}}
{{familytree | | | | | | | | | | | | | | |,| B03 | | | | |B03= }}
{{familytree | | | | | | | | | | | | | | |!| | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | |)| B05 | | | | | B05= | | | | | | }}
{{familytree | | | | | | | | | |,|-| B01 |(| | | | | | | B01= | | | | | | }}
{{familytree | | | | | | | | | |!| | | | |)| B02 | | | | | |B02= }}
{{familytree | | | | | | | | | |!| | | | |!| | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |!| | | | |`| B04 | | | | | B04= | | | | | }}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |!| | | | |,| C04 | | | | C04= | | | | | | }}
{{familytree | | | | | | | | | |!| | | | |!| | | | | | | | | | | | | }}
{{familytree | | | | | | F01 |-|+|-| C02 |+| C03 | | | |F01= |C02= |C03= }}
{{familytree | | | | | | | | | |!| | | | |!| | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |!| | | | |`| C05 | | | | C05= | | | | | | }}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |`|-| D01 |-| D02 | | | |D01= |D02= }}
{{familytree/end}}
Intermediate risk neuroblastoma patients include:


Group 1


Patients with stage 2A/2B (<50% resected or Bx only) tumor, 0-12 years of age, irrespective of the grade, MYCNnot amplified
Patients with stage 3 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified
Patients with stage 3 tumor, 1-12 years of age, favorable histology, MYCNnot amplified
Patients with symptomatic stage 4S, <365 days of age, favorable histology, DNA index >1, MYCNnot amplified


Group 2


Patients with stage 3 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified
Patients with stage 4 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified
Patients with stage 4S tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified


Group 3


Patients with stage 4 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified
* '''High risk neuroblastoma patients''' include:
Patients with stage 3 tumor, 365-547 days of age, unfavorable histology, MYCN not amplified
:* Patients with stage 2A/2B, 3, 4, or 4S tumor, irrespective of the age, irrespective of the grade, ''MYCN'' amplified
Patients with stage 4 tumor, 365-547 days of age, favorable histology, DNA index >1, MYCN not amplified
:* Patients with stage 3 tumor, ≥ 547 days of age, unfavorable histology, ''MYCN'' not amplified
:* Patients with stage 4 tumor, 365-547 days of age, unfavorable histology, DNA index=1, ''MYCN'' not amplified  
:* Patients with stage 4 tumor, >547 days of age, irrespective the grade, ''MYCN'' amplification state

Latest revision as of 03:06, 10 October 2015

 
 
 
 
 
 
 
 
 
 
 
  • INNS stage 2A/2B, Stage 3 , Stage 4 or Stage 4S
  • Irrespective of age
  • Irrespective of grade
  • MYCN amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INSS stage 3
  • >547 days of age
  • Unfavorable histology
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
Intermediate risk neuroblastoma patients (group 2)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INNS stage 4
  • 365-547 days of age
  • Unfavorable histology
  • DNA index=1
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • Symptomatic INNS stage 4
  • >547 days of age
  • Irrespective grade
  • Irrespective MYCN amplification state
 
 
 
 
 
 
 
 




  • High risk neuroblastoma patients include:
  • Patients with stage 2A/2B, 3, 4, or 4S tumor, irrespective of the age, irrespective of the grade, MYCN amplified
  • Patients with stage 3 tumor, ≥ 547 days of age, unfavorable histology, MYCN not amplified
  • Patients with stage 4 tumor, 365-547 days of age, unfavorable histology, DNA index=1, MYCN not amplified
  • Patients with stage 4 tumor, >547 days of age, irrespective the grade, MYCN amplification state
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