Sandbox:risk

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  • INNS stage 2A/2B, Stage 3 , Stage 4 or Stage 4S
  • Irrespective of age
  • Irrespective of grade
  • MYCN amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INSS stage 3
  • >547 days of age
  • Unfavorable histology
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
Intermediate risk neuroblastoma patients (group 2)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INNS stage 4
  • 365-547 days of age
  • Unfavorable histology
  • DNA index=1
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • Symptomatic INNS stage 4
  • >547 days of age
  • Irrespective grade
  • Irrespective MYCN amplification state
 
 
 
 
 
 
 
 




  • High risk neuroblastoma patients include:
  • Patients with stage 2A/2B, 3, 4, or 4S tumor, irrespective of the age, irrespective of the grade, MYCN amplified
  • Patients with stage 3 tumor, ≥ 547 days of age, unfavorable histology, MYCN not amplified
  • Patients with stage 4 tumor, 365-547 days of age, unfavorable histology, DNA index=1, MYCN not amplified
  • Patients with stage 4 tumor, >547 days of age, irrespective the grade, MYCN amplification state
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