Glioblastoma multiforme differential diagnosis: Difference between revisions

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{{Glioblastoma multiforme}}
{{Glioblastoma multiforme}}
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==Overview==
==Overview==
 
Glioblastoma must be differentiated from [[Metastasis|cerebral metastasis]], [[primary CNS lymphoma]], [[cerebral abscess]], [[Astrocytoma|anaplastic astrocytoma]], [[Demyelination|tumefactive demyelination]], [[stroke]], [[Toxoplasmosis|cerebral toxoplasmosis]], [[Radiation|radiation necrosis]], [[encephalitis]], [[oligodendroglioma]], and [[epilepsy]].<ref name=ddd>DDx of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref>
==Differentiating Glioblastoma multiforme from other Diseases==
==Differentiating Glioblastoma multiforme from other Diseases==
Glioblastoma must be differentiated from:<ref name=ddd>DDx of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref>
Glioblastoma must be differentiated from the following:<ref name=ddd>DDx of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref>


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*Central restricted diffusion is helpful
*Central restricted diffusion is helpful
*[[Hemorrhagic]] then assessment may be difficult  
*Hemorrhagic then assessment may be difficult  
*Presence of smooth and complete SWI low intensity rim
*Presence of smooth and complete SWI low intensity rim
*Presence of dual rim sign
*Presence of dual rim sign

Revision as of 13:41, 18 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Glioblastoma must be differentiated from cerebral metastasis, primary CNS lymphoma, cerebral abscess, anaplastic astrocytoma, tumefactive demyelination, stroke, cerebral toxoplasmosis, radiation necrosis, encephalitis, oligodendroglioma, and epilepsy.[1]

Differentiating Glioblastoma multiforme from other Diseases

Glioblastoma must be differentiated from the following:[1]

Differential diagnosis Characteristic features of the differential diagnosis
Cerebral metastasis
  • May look identical
  • Both may appear multifocal
  • Metastases are centred on grey-white matter junction and spare the overlying cortex
Primary CNS lymphoma
  • In patients with AIDS
  • Central necrosis is more common
  • Homogeneously enhancing on MRI
Cerebral abscess
  • Central restricted diffusion is helpful
  • Hemorrhagic then assessment may be difficult
  • Presence of smooth and complete SWI low intensity rim
  • Presence of dual rim sign
Anaplastic astrocytoma
Tumefactive demyelination
  • Can appear similar
  • Open ring pattern of enhancement
  • Younger patients
Stroke
  • History is suggestive of diagnosis
  • No elevated choline
Cerebral toxoplasmosis
  • In patients with AIDS
Radiation necrosis
Encephalitis
Oligodendroglioma
Epilepsy
  • Multifactorial
  • Mass may or may not be observed on MRI depending on the cause

References

  1. 1.0 1.1 DDx of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma


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