ZMA (supplement)

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ZMA (Zinc monomethionine aspartate and Magnesium Aspartate) is a supplement used by bodybuilders and athletes. It was developed by Victor Conte (founder of BALCO Laboratories in Burlingame, California) and is a combination of zinc, magnesium and vitamin B6. The formula is "patent pending" and the name "ZMA" trademarked by SNAC System Inc, also founded by Victor Conte. ZMA is claimed to raise testosterone and IGF-1 levels which may aid in gaining muscle size and strength. It is used as a bodybuilding supplement.

ZMA is a combination of two minerals, zinc and magnesium, and Vitamin B-6 or pyridoxine. All three of these compounds are important in biological processes, and while studies have shown that most Americans get enough zinc and Vitamin B6,[1] more than 50% are deficient in magnesium.[2]

An increase in exercise can lead to the loss of vitamins and minerals making it particularly important for bodybuilding due to the blood sugar level rises and urination increases, increasing the loss of magnesium, zinc, B12, B6, folic acid, and many other nutrients. Although drinking water re-hydrates an athlete, fruit juice, sports drinks or foods high in water such as vegetables are needed to replenish water-soluble nutrients.

The proportion of ingredients generally used in products is 20-30 mg Zinc, 400-500 mg Magnesium and ~10mg B6. According to the label directions, ZMA should be taken before bed on an empty stomach (2 hours after eating your last meal and at least 30 minutes prior to any other supplements). The product should not be taken with calcium.

Scientific studies

A 1999 study was undertaken on NCAA Football players during an 8 week spring training program. Those who took the ZMA tablets showed greater increases in muscle strength, free testosterone levels, and IGF-1 levels. These ZMA study results were presented by Dr. Brilla (a sports performance researcher at Western Washington University) on June 2, 1999, at the 46th Annual Meeting of the American College of Sports Medicine in Seattle, Washington. This study was funded by SNAC Systems Inc. (the patent holders) and one of the study's authors (Victor Conte) has equity in this company.

Another study in 2004 found that ZMA has no effect on strength or hormone levels, but did show a lower rate of muscle catabolism and cited further study was recommended.[3]


  1. "Ohio State University Extension Fact Sheet". Retrieved 2006-08-11.
  2. "More than half of Americans don't get nearly enough magnesium" (PDF). Retrieved 2006-08-11.
  3. Wilborn Colin D.; et al. (2004). "Effects of Zinc Magnesium Aspartate (ZMA) Supplementation on Training Adaptations and Markers of Anabolism and Catabolism" (PDF). Journal of the International Society of Sports Nutrition. 1 (2): 12–20.
  • Lukaski HC (2000). "Magnesium, zinc, and chromium nutriture and physical activity". American Journal of Clinical Nutrition. 72 (2): 585s–593s. Text " Brilla LR, Conte, V. A novel zinc and magnesium formulation (ZMA) increases anabolic hormones and strength in athletes. Sport Med Train and Rehab (in press). Abstract presented November 14, 1998 at the 18th Annual Meeting of the S.W. Chapter of the ACSM
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