XPA

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Xeroderma pigmentosum, complementation group A
250px
PDB rendering based on 1d4u.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols XPA ; XP1; XPAC
External IDs Template:OMIM5 Template:MGI HomoloGene37298
RNA expression pattern
File:PBB GE XPA 205672 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Xeroderma pigmentosum, complementation group A, also known as XPA, is a human gene.[1]


References

  1. "Entrez Gene: XPA xeroderma pigmentosum, complementation group A".

Further reading

  • Cleaver JE, Thompson LH, Richardson AS, States JC (1999). "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy". Hum. Mutat. 14 (1): 9–22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.
  • Morikawa K, Shirakawa M (2000). "Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA". Mutat. Res. 460 (3–4): 257–75. PMID 10946233.
  • Satokata I, Tanaka K, Okada Y (1992). "Molecular basis of group A xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene". Hum. Genet. 88 (6): 603–7. PMID 1339397.
  • Satokata I, Tanaka K, Yuba S, Okada Y (1992). "Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum". Mutat. Res. 273 (2): 203–12. PMID 1372103.
  • Miyamoto I, Miura N, Niwa H; et al. (1992). "Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair". J. Biol. Chem. 267 (17): 12182–7. PMID 1601884.
  • Satokata I, Tanaka K, Miura N; et al. (1991). "Characterization of a splicing mutation in group A xeroderma pigmentosum". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9908–12. PMID 1702221.
  • Miura N, Miyamoto I, Asahina H; et al. (1991). "Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene". J. Biol. Chem. 266 (29): 19786–9. PMID 1918083.
  • Tanaka K, Miura N, Satokata I; et al. (1990). "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain". Nature. 348 (6296): 73–6. doi:10.1038/348073a0. PMID 2234061.
  • Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. 15 (10): 5396–402. PMID 7565690.
  • Nagai A, Saijo M, Kuraoka I; et al. (1995). "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochem. Biophys. Res. Commun. 211 (3): 960–6. PMID 7598728.
  • Farndon PA, Morris DJ, Hardy C; et al. (1995). "Analysis of 133 meioses places the genes for nevoid basal cell carcinoma (Gorlin) syndrome and Fanconi anemia group C in a 2.6-cM interval and contributes to the fine map of 9q22.3". Genomics. 23 (2): 486–9. doi:10.1006/geno.1994.1528. PMID 7835901.
  • Park CH, Mu D, Reardon JT, Sancar A (1995). "The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor". J. Biol. Chem. 270 (9): 4896–902. PMID 7876263.
  • Li L, Elledge SJ, Peterson CA; et al. (1994). "Specific association between the human DNA repair proteins XPA and ERCC1". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5012–6. PMID 8197174.
  • Park CH, Sancar A (1994). "Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5017–21. PMID 8197175.
  • Satokata I, Iwai K, Matsuda T; et al. (1994). "Genomic characterization of the human DNA excision repair-controlling gene XPAC". Gene. 136 (1–2): 345–8. PMID 8294029.
  • Tanaka K (1993). "The Japan Society of Human Genetics Award Lecture. Molecular analysis of xeroderma pigmentosum group A gene". Jpn. J. Hum. Genet. 38 (1): 1–14. PMID 8504220.
  • Topping RS, Myrand SP, Williams BL; et al. (1996). "Characterization of the human XPA promoter". Gene. 166 (2): 341–2. PMID 8543191.
  • Lench NJ, Telford EA, Andersen SE; et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
  • Selby CP, Sancar A (1997). "Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II". J. Biol. Chem. 272 (3): 1885–90. PMID 8999876.
  • Hayashi T, Takao M, Tanaka K, Yasui A (1998). "ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines". Mutat. Res. 407 (3): 269–76. PMID 9653453.

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