Warthin's tumor pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2] Nazia Fuad M.D.

Overview

Warthin's tumor arises from salivary gland epithelium, which are secretory cells of the salivary gland. On gross pathology, cystic and multicentric appearance are characteristic findings of Warthin's tumor. On microscopic histopathological analysis, papillae, fibrous capsule, and cystic spaces are characteristic findings of Warthin's tumor.

Pathophysiology

Pathogenesis

The exact pathogenesis of warthins tumor is not completely understood. Acording to a study in 2016, :

• Stroma and parenchyma of the tumor was histopathologically analyzed.
• The epithelial and stromal component was equally distributed in tumor mass.
• This study showed that the Warthin's tumor occurs as a result of of inflammatory process.
• Epithelial part of the Warthin's tumor is the main trigger for the tumor process.

Genetics

• Expression of CRTC1 - MAML2 chimeric genes through t(11;19)(q21;p13) translocation is involved in the pathogenesis of Warthin's tumor.

Gross Pathology

Characteristic findings of warthin's tumor on gross pathology are;

• Size of the tumor varies between 2-5 cm.
• The tumor is well demarcated, grey yellow in color.
• It is encapsulated, lobulated and multicentric.
• Warthin;s tumor can be fixed to overlying skin.
• 10-15% are multifocal/bilateral.
• Tumor can have serous/mucinous secretion.

Microscopic Pathology

On microscopic histopathological analysis the characteristic findings of warthin;s tumor are;

• Dense lymphoid stroma with double layer of epithelial cells resting on the stroma.
• The cystic spaces are present which are narrowed by polypoid projections.
• Basal cell layer is not continuous and is interrupted in places .
• The oncocytic columnar cells palisade on the surface.
• There is no myoepithelial component present in tumor.
• Occasional features include cilia, squamous metaplasia with necrosis, mast cells, dendritic cells and sebaceous cells.

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References

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