WISP1

WNT1 inducible signaling pathway protein 1
Identifiers
Symbols	WISP1 ; CCN4; WISP1c; WISP1i; WISP1tc
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2883
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WISP1 206796 at tn.png
File:PBB GE WISP1 211312 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WNT1 inducible signaling pathway protein 1, also known as WISP1, is a human gene.

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.

Further reading

• Pennica D, Swanson TA, Welsh JW; et al. (1999). "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14717–22. PMID 9843955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu L, Corcoran RB, Welsh JW; et al. (2000). "WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene". Genes Dev. 14 (5): 585–95. PMID 10716946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Sugimachi K, Saeki H; et al. (2001). "A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma". Oncogene. 20 (39): 5525–32. doi:10.1038/sj.onc.1204723. PMID 11571650.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Desnoyers L, Arnott D, Pennica D (2002). "WISP-1 binds to decorin and biglycan". J. Biol. Chem. 276 (50): 47599–607. doi:10.1074/jbc.M108339200. PMID 11598131.CS1 maint: Multiple names: authors list (link)
• Xie D, Nakachi K, Wang H; et al. (2002). "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features". Cancer Res. 61 (24): 8917–23. PMID 11751417.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Su F, Overholtzer M, Besser D, Levine AJ (2002). "WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase". Genes Dev. 16 (1): 46–57. doi:10.1101/gad.942902. PMID 11782444.CS1 maint: Multiple names: authors list (link)
• Saxena N, Banerjee S, Sengupta K; et al. (2002). "Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines". Mol. Cell. Biochem. 228 (1–2): 99–104. PMID 11855747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soon LL, Yie TA, Shvarts A; et al. (2003). "Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation". J. Biol. Chem. 278 (13): 11465–70. doi:10.1074/jbc.M210945200. PMID 12529380.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Sugimachi K, Kameyama T; et al. (2003). "Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma". Hepatology. 37 (5): 1122–9. doi:10.1053/jhep.2003.50187. PMID 12717393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hocevar BA, Mou F, Rennolds JL; et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMID 12805222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cervello M, Giannitrapani L, Labbozzetta M; et al. (2005). "Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells". Ann. N. Y. Acad. Sci. 1028: 432–9. doi:10.1196/annals.1322.051. PMID 15650268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nusbaum C, Mikkelsen TS, Zody MC; et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yanagita T, Kubota S, Kawaki H; et al. (2007). "Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes". FEBS J. 274 (7): 1655–65. doi:10.1111/j.1742-4658.2007.05709.x. PMID 17381509.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davies SR, Watkins G, Mansel RE, Jiang WG (2007). "Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer". Ann. Surg. Oncol. 14 (6): 1909–18. doi:10.1245/s10434-007-9376-x. PMID 17406949.CS1 maint: Multiple names: authors list (link)
• Urano T, Narusawa K, Shiraki M; et al. (2007). "Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women". J. Bone Miner. Metab. 25 (4): 253–8. doi:10.1007/s00774-007-0757-9. PMID 17593496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tian C, Zhou ZG, Meng WJ; et al. (2007). "Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients". World J. Gastroenterol. 13 (28): 3878–82. PMID 17657846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamashita T, Budhu A, Forgues M, Wang XW (2007). "Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma". Cancer Res. 67 (22): 10831–9. doi:10.1158/0008-5472.CAN-07-0908. PMID 18006828.CS1 maint: Multiple names: authors list (link)