WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4gene.[1][2]
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.[2]
Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site". Mol. Cell. 18 (2): 245–51. doi:10.1016/j.molcel.2005.03.018. PMID15837427.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID10748127.
