Jump to navigation Jump to search

WikiDoc Resources for Thromboxane


Most recent articles on Thromboxane

Most cited articles on Thromboxane

Review articles on Thromboxane

Articles on Thromboxane in N Eng J Med, Lancet, BMJ


Powerpoint slides on Thromboxane

Images of Thromboxane

Photos of Thromboxane

Podcasts & MP3s on Thromboxane

Videos on Thromboxane

Evidence Based Medicine

Cochrane Collaboration on Thromboxane

Bandolier on Thromboxane

TRIP on Thromboxane

Clinical Trials

Ongoing Trials on Thromboxane at Clinical

Trial results on Thromboxane

Clinical Trials on Thromboxane at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Thromboxane

NICE Guidance on Thromboxane


FDA on Thromboxane

CDC on Thromboxane


Books on Thromboxane


Thromboxane in the news

Be alerted to news on Thromboxane

News trends on Thromboxane


Blogs on Thromboxane


Definitions of Thromboxane

Patient Resources / Community

Patient resources on Thromboxane

Discussion groups on Thromboxane

Patient Handouts on Thromboxane

Directions to Hospitals Treating Thromboxane

Risk calculators and risk factors for Thromboxane

Healthcare Provider Resources

Symptoms of Thromboxane

Causes & Risk Factors for Thromboxane

Diagnostic studies for Thromboxane

Treatment of Thromboxane

Continuing Medical Education (CME)

CME Programs on Thromboxane


Thromboxane en Espanol

Thromboxane en Francais


Thromboxane in the Marketplace

Patents on Thromboxane

Experimental / Informatics

List of terms related to Thromboxane


Thromboxane A2
Error creating thumbnail: File missing
Thromboxane B2

Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.

Thromboxane is named for its role in clot formation (thrombosis).


Enzymes and substrates associated with thromoboxane and prostacyclin synthesis.

It is produced in platelets by thromboxane-A synthase from the endoperoxides produced by the cyclooxygenase (COX) enzyme from arachidonic acid.


Thromboxane acts by binding to any of the thromboxane receptors, G-protein coupled receptors coupled to the G protein Gq[1].


Thromboxane is a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation.

It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The mechanism of secretion of thromboxanes from platelets is still unclear.

Role of A2 in platelet aggregation

Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets as well as increasing platelet aggregation.

Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of platelets. Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot.


It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal's angina.


The widely used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets.

It inhibits the COX enzyme both non-competitively and irreversibly.

The side effect of this is that people who regularly take aspirin will suffer from excessive bleeding whenever the skin is perforated.

External links



Template:Jb1 Template:WH Template:WikiDoc Sources