Thiosulfate dehydrogenase

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In enzymology, a thiosulfate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

2 thiosulfate + 2 ferricytochrome c tetrathionate + 2 ferrocytochrome c

Thus, the two substrates of this enzyme are thiosulfate and ferricytochrome c, whereas its two products are tetrathionate and ferrocytochrome c.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a cytochrome as acceptor. The systematic name of this enzyme class is thiosulfate:ferricytochrome-c oxidoreductase. Other names in common use include tetrathionate synthase, thiosulfate oxidase, thiosulfate-oxidizing enzyme, and thiosulfate-acceptor oxidoreductase.


  • IUBMB entry for
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  • Lu, W-P and Kelly DP (1988). "Cellular location and partial purification of the 'thiosulphate-oxidizing enzyme' and 'trithionate hydrolase' from Thiobacillus tepidarius". J. Gen. Microbiol. 134: 877&ndash, 885.

External links

The CAS registry number for this enzyme class is 9076-88-4.

Gene Ontology (GO) codes