TRIM37

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Tripartite motif-containing protein 37 is a protein that in humans is encoded by the TRIM37 gene.

Function

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein–protein and/or protein–nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.

Interactions

TRIM37 has been shown to interact with PRC1.

See also

• Mulibrey nanism

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (Jun 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
• Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
• Lehesjoki AE, Reed VA, Mark Gardiner R, Greene ND (Oct 2001). "Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis". Mechanisms of Development. 108 (1–2): 221–5. doi:10.1016/S0925-4773(01)00491-9. PMID 11578880.
• Kallijärvi J, Avela K, Lipsanen-Nyman M, Ulmanen I, Lehesjoki AE (May 2002). "The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder". American Journal of Human Genetics. 70 (5): 1215–28. doi:10.1086/340256. PMC 447596. PMID 11938494.
• Jagiello P, Hammans C, Wieczorek S, Arning L, Stefanski A, Strehl H, Epplen JT, Gencik M (Jun 2003). "A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity". Human Mutation. 21 (6): 630–5. doi:10.1002/humu.10220. PMID 12754710.
• Hämäläinen RH, Avela K, Lambert JA, Kallijärvi J, Eyaid W, Gronau J, Ignaszewski AP, McFadden D, Sorge G, Lipsanen-Nyman M, Lehesjoki AE (May 2004). "Novel mutations in the TRIM37 gene in Mulibrey Nanism". Human Mutation. 23 (5): 522. doi:10.1002/humu.9233. PMID 15108285.
• Kallijärvi J, Lahtinen U, Hämäläinen R, Lipsanen-Nyman M, Palvimo JJ, Lehesjoki AE (Aug 2005). "TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase". Experimental Cell Research. 308 (1): 146–55. doi:10.1016/j.yexcr.2005.04.001. PMID 15885686.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Karlberg N, Jalanko H, Kallijärvi J, Lehesjoki AE, Lipsanen-Nyman M (Dec 2005). "Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37". Diabetes. 54 (12): 3577–81. doi:10.2337/diabetes.54.12.3577. PMID 16306379.
• Hämäläinen RH, Joensuu T, Kallijärvi J, Lehesjoki AE (Jan 2006). "Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing". Gene. 366 (1): 180–8. doi:10.1016/j.gene.2005.08.008. PMID 16310976.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Hämäläinen RH, Mowat D, Gabbett MT, O'brien TA, Kallijärvi J, Lehesjoki AE (Dec 2006). "Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism". Clinical Genetics. 70 (6): 473–9. doi:10.1111/j.1399-0004.2006.00700.x. PMID 17100991.
• Doğanc T, Yüksel Konuk BE, Alpan N, Konuk O, Hämäläinen RH, Lehesjoki AE, Tekin M (Jul 2007). "A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy". Clinical Dysmorphology. 16 (3): 173–6. doi:10.1097/MCD.0b013e3280f6d00b. PMID 17551331.