TAGLN

Transgelin
File:PBB Protein TAGLN image.jpg PDB rendering based on 1ujo.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ujo​
Identifiers
Symbols	TAGLN ; SMCC; DKFZp686P11128; SM22; TAGLN1; WS3-10
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2398
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE TAGLN 205547 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transgelin, also known as TAGLN, is a human gene.

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.

Further reading

• Thweatt R, Lumpkin CK, Goldstein S (1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem. Biophys. Res. Commun. 187 (1): 1–7. PMID 1520290.CS1 maint: Multiple names: authors list (link)
• Nishida W, Kitami Y, Abe M, Hiwada K (1991). "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle". Biochem. Int. 23 (4): 663–8. PMID 1872880.CS1 maint: Multiple names: authors list (link)
• Nagase T, Miyajima N, Tanaka A; et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. PMID 7788527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi R, Kubota T, Hidaka H (1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog". Biochem. Biophys. Res. Commun. 198 (3): 1275–80. doi:10.1006/bbrc.1994.1180. PMID 8117285.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Li L, Liu Z, Mercer B; et al. (1997). "Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells". Dev. Biol. 187 (2): 311–21. PMID 9242426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamamura H, Masuda H, Ikeda W; et al. (1997). "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation". J. Biochem. 122 (1): 157–67. PMID 9276683.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lawson D, Harrison M, Shapland C (1998). "Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines". Cell Motil. Cytoskeleton. 38 (3): 250–7. doi:10.1002/(SICI)1097-0169(1997)38:3<250::AID-CM3>3.0.CO;2-9. PMID 9384215.CS1 maint: Multiple names: authors list (link)
• Camoretti-Mercado B, Forsythe SM, LeBeau MM; et al. (1998). "Expression and cytogenetic localization of the human SM22 gene (TAGLN)". Genomics. 49 (3): 452–7. doi:10.1006/geno.1998.5267. PMID 9615232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu Y, Liu HW, Forsythe SM; et al. (2001). "Mutagenesis analysis of human SM22: characterization of actin binding". J. Appl. Physiol. 89 (5): 1985–90. PMID 11053353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shields JM, Rogers-Graham K, Der CJ (2002). "Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways". J. Biol. Chem. 277 (12): 9790–9. doi:10.1074/jbc.M110086200. PMID 11773051.CS1 maint: Multiple names: authors list (link)
• Chainiaux F, Magalhaes JP, Eliaers F; et al. (2002). "UVB-induced premature senescence of human diploid skin fibroblasts". Int. J. Biochem. Cell Biol. 34 (11): 1331–9. PMID 12200029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu R, Ho YS, Ritchie RP, Li L (2003). "Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stages". Am. J. Physiol. Heart Circ. Physiol. 284 (4): H1398–407. doi:10.1152/ajpheart.00737.2002. PMID 12521938.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Z, Chang YJ, Miyamoto H; et al. (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liao X, Li S, Lou Z; et al. (2007). "Crystallization and preliminary crystallographic analysis of transgelin". Protein Pept. Lett. 14 (2): 209–11. PMID 17305610.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)