Syphilis/Immunoassay

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Overview

  • Following positive non-treponemal tests, FTA-ABS is commonly used to confirm the diagnosis. Sensitivity ranges from 84% for detection of primary infection to approximately 100% for the diagnosis of other stages with a specificity of 96%.[3]
  • Unfortunately, false positives can still occur in related treponomal infections such as yaws and pinta.

Resources

References

  1. Schmid GP (1996). "Serologic screening for syphilis. Rationale, cost, and realpolitik". Sexually Transmitted Diseases. 23 (1): 45–50. PMID 8801642. Retrieved 2012-02-16.
  2. Young H (1998). "Syphilis. Serology". Dermatologic Clinics. 16 (4): 691–8. PMID 9891668. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
  3. Golden MR, Marra CM, Holmes KK (2003). "Update on syphilis: resurgence of an old problem". JAMA : the Journal of the American Medical Association. 290 (11): 1510–4. doi:10.1001/jama.290.11.1510. PMID 13129993. Retrieved 2012-02-16. Unknown parameter |month= ignored (help)
  4. Workowski KA, Berman S (2010). "Sexually transmitted diseases treatment guidelines, 2010". MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports / Centers for Disease Control. 59 (RR-12): 1–110. PMID 21160459. Retrieved 2012-02-16. Unknown parameter |month= ignored (help)


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