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- WBR0226 + (Pituitary enlargement and hyperpigmentatio … Pituitary enlargement and hyperpigmentation following bilateral adrenalectomy is called Nelson’s syndrome. The cause of pituitary enlargement is loss of feedback by adrenal glucocorticoids following the adrenalectomy. The tumour is aggressive and is treated by surgery or pituitary radiation.<br/></br>'''Educational Objective:''' <br/></br>'''References:'''ducational Objective:''' <br/> '''References:''')