Sodium aurothiosulfate

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Sodium aurothiosulfate
320px-Na3Au(S2O3)2.png
800px-Sodium-gold(I)-thiosulfate-dihydrate-unit-cell-3D-balls.png
Clinical data
Routes of
administration
Intramuscular injection
ATC code
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaAuNa3O6S4
Molar mass332.08452 g/mol
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Sodium aurothiosulfate is the inorganic compound with the formula Na3Au(S2O3)2·2H2O. This salt contains an anionic linear coordination complex of gold(I) bound to two thiosulfate ligands.[1][2] Like several other gold compounds, this species is used as an antirheumatic.[3]The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was compared with distilled water for the treatment of tuberculosis.[4]

References

  1. Baggio, R (1973). "Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na3[Au(S2O3)2],2H2O". Journal of Inorganic and Nuclear Chemistry. 35 (9): 3191. doi:10.1016/0022-1902(73)80019-3.
  2. Tobön-Zapata, G (1997). "Vibrational spectrum of Sanocrysin". Spectrochimica Acta Part a Molecular and Biomolecular Spectroscopy. 53 (2): 183. doi:10.1016/S1386-1425(97)83024-7.
  3. Shaw, III, C. F. (1999). "Gold-Based Therapeutic Agents". Chemical Reviews. 99 (9): 2589–600. doi:10.1021/cr980431o. PMID 11749494.
  4. Ethical and regulatory aspects of clinical research: readings and commentary, Ezekiel J. Emanuel, Johns Hopkins University Press, 2003, p 140

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