snRNP70

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's Disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's Disease.

Interactions

snRNP70 has been shown to interact with ASF/SF2, SRPK1, and ZRANB2.

Role in autoimmunity

Antibodies towards snRNP70 are associated with mixed connective tissue disease.

Further reading

• Wilk HE, Schaefer KP, Agris PF, Boak AM, Kovacs SA (July 1991). "U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA". Molecular and Cellular Biochemistry. 106 (1): 55–66. doi:10.1007/BF00231189. PMID 1833625.
• Query CC, Bentley RC, Keene JD (April 1989). "A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein". Cell. 57 (1): 89–101. doi:10.1016/0092-8674(89)90175-X. PMID 2467746.
• Du Clos TW (October 1989). "C-reactive protein reacts with the U1 small nuclear ribonucleoprotein". Journal of Immunology. 143 (8): 2553–9. PMID 2477447.
• Theissen H, Etzerodt M, Reuter R, Schneider C, Lottspeich F, Argos P, Lührmann R, Philipson L (December 1986). "Cloning of the human cDNA for the U1 RNA-associated 70K protein". The EMBO Journal. 5 (12): 3209–17. PMC 1167314. PMID 3028775.
• Romac JM, Graff DH, Keene JD (July 1994). "The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain". Molecular and Cellular Biology. 14 (7): 4662–70. PMC 358839. PMID 7516470.
• Wu JY, Maniatis T (December 1993). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing". Cell. 75 (6): 1061–70. doi:10.1016/0092-8674(93)90316-I. PMID 8261509.
• Woppmann A, Will CL, Kornstädt U, Zuo P, Manley JL, Lührmann R (June 1993). "Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors". Nucleic Acids Research. 21 (12): 2815–22. doi:10.1093/nar/21.12.2815. PMC 309659. PMID 8332490.
• Northemann W, Berg H, Stahnke G, Walter M, Hunt N, Fenning S (December 1995). "Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen". Protein Expression and Purification. 6 (6): 748–56. doi:10.1006/prep.1995.0005. PMID 8746626.
• Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–8. PMC 231539. PMID 8816452.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R (January 1997). "Association of U2 snRNP with the spliceosomal complex E". Nucleic Acids Research. 25 (2): 354–61. doi:10.1093/nar/25.2.354. PMC 146436. PMID 9016565.
• Klein Gunnewiek JM, van Aarssen Y, van der Kemp A, Nelissen R, Pruijn GJ, van Venrooij WJ (August 1997). "Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus". Experimental Cell Research. 235 (1): 265–73. doi:10.1006/excr.1997.3663. PMID 9281376.
• Zhang WJ, Wu JY (February 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Molecular and Cellular Biology. 18 (2): 676–84. PMC 108778. PMID 9447963.
• Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
• Cao W, Garcia-Blanco MA (August 1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding". The Journal of Biological Chemistry. 273 (32): 20629–35. doi:10.1074/jbc.273.32.20629. PMID 9685421.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Xiao SH, Manley JL (November 1998). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". The EMBO Journal. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMC 1170960. PMID 9799243.
• Dumortier H, Klein Gunnewiek J, Roussel JP, van Aarssen Y, Briand JP, van Venrooij WJ, Muller S (December 1998). "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle". Nucleic Acids Research. 26 (23): 5486–91. doi:10.1093/nar/26.23.5486. PMC 147990. PMID 9826776.