Small Cajal body specific RNA 13
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In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
U93 is composed of two tandemly arranged box H/ACA box sequence motifs and belongs to the H/ACA box class of guide RNAs [2]. U93 is predicted to guide pseudouridylation of U2 spliceosomal snRNA residue U54 and residue U53 of snRNA U5 [2][3][4].
References
- ↑ Darzacq, X (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21: 2746&ndash, 2756. PMID 12032087. Unknown parameter
|coauthors=ignored (help) - ↑ 2.0 2.1 Kiss AM, Jády BE, Darzacq X, Verheggen C, Bertrand E, Kiss T (2002). "A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains". Nucleic Acids Res. 30 (21): 4643–9. PMID 12409454.
- ↑ Lestrade, L (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158&ndash, D162. PMID 16381836. Unknown parameter
|coauthors=ignored (help) - ↑ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMID 16373490.
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