Siccardi syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Siccardi syndrome is a very rare heritable disease of the neutrophils.

Pathophysiology

Siccardi syndrome is supposed to be caused by defective neutrophil function. As a result bacterial destruction by neutrophils is deficient.

Diagnosis

Symptoms

• Recurrent infections

Physical Examination

Skin

• Gray skin
• Gray hair

Head

• Swollen lymph nodes

Abdomen

• Hepatosplenomegaly