Sandbox chemo2

5+2 - Used for acute myelogenous leukemia, reinduction Cytarabine 100 to 200 mg/m(2)/day IV, continuous infusion days 1 to 5 WITH DAUNOrubicin 45 mg/m(2) IV, days 1 to 2 OR MitoXANTRONE 12 mg/m(2) IV, days 1 to 2

7+3 - Used for acute myelogenous leukemia, induction Cytarabine 100 to 200 mg/m(2)/day, continuous infusion days 1 to 7 WITH DAUNOrubicin 45 mg/m(2) IV, days 1 to 3 OR Idarubicin 12 mg/m(2) IV, days 1 to 3 OR MitoXANTRONE 12 mg/m(2) IV, days 1 to 3

ABVD - Used for Hodgkin's disease Doxorubicin 25 mg/m(2) IV, days 1 and 15 Bleomycin 10 units/m(2) IV, days 1 and 15 VinBLAStine 6 mg/m(2) IV, days 1 and 15 Dacarbazine 350 to 375 mg/m(2) IV, days 1 and 15 Repeat cycle every 28 days

AC - Used for multiple myeloma Doxorubicin 30 mg/m(2) IV, day 1 Carmustine 30 mg/m(2) IV, day 1 Repeat cycle every 21 to 28 days

AC - Used for breast cancer Doxorubicin 60 mg/m(2) IV, day 1 Cyclophosphamide 600 mg/m(2) IV, day 1 Repeat cycle every 21 days [4]

Sequential AC-Paclitaxel - Used for breast cancer Doxorubicin 60 mg/m(2) IV, day 1; given concomitantly with Cyclophosphamide 600 mg/m(2) IV day 1; followed by Paclitaxel 175 to 225 mg/m(2) IV, day 1 Repeat every 21 days for 4 cycles [5][6][7]

Doxorubicin 60 mg/m(2) IV on day 1, every 21 days, for 4 cycles Cyclophosphamide 600 mg/m(2) IV on day 1, every 21 days, for 4 cycles; followed by Paclitaxel 80 mg/m(2) IV, day 1 (repeat every 7 days for 12 cycles) OR 175 mg/m(2) IV over 3 hr, day 1 (repeat every 21 days for 4 cycles) [8][9]

Dose-Dense AC-T - Used for breast cancer Doxorubicin 60 mg/m(2) IV, day 1; given concomitantly with Cyclophosphamide 600 mg/m(2) IV day 1, repeat every 14 days for 4 cycles; followed by Paclitaxel 175 mg/m(2) IV, day 1, repeat every 14 days for 4 cycles Patients undergoing treatment with this regimen should receive primary prophylaxis for neutropenia [7].

Sequential AC followed by T with Trastuzumab - Used for breast cancer Doxorubicin 60 mg/m(2) IV on day 1, given concomitantly with Cyclophosphamide 600 mg/m(2) IV on day 1, every 21 days, for 4 cycles; followed by Paclitaxel 80 mg/m(2) IV, day 1 (repeat every 7 days for 12 cycles) OR 175 mg/m(2) IV over 3 hr, day 1 (repeat every 21 days for 4 cycles) Trastuzumab 4 mg/kg IV infuse over 90 min, day 1, with first dose of paclitaxel, and followed by weekly doses of 2 mg/kg IV infuse over 30 min for 51 weeks [8][9][10]

AD - Used for sarcoma Doxorubicin 22.5 mg/m(2)/day continuous infusion, days 1 to 4 Dacarbazine 225 mg/m(2)/day continuous infusion, days 1 to 4 Repeat cycle every 21 days

AP - Used for endometrial cancer Doxorubicin *60 mg/m(2) IV, day 1 Cisplatin 50 mg/m(2) IV, day 1 Repeat cycle every 21 days [11]

• Patients who had received prior pelvic radiotherapy or who were older than 65 years were to receive doxorubicin 45 mg/m(2)

Dose-Dense A-T-C - Used for breast cancer Doxorubicin 60 mg/m(2) IV, every 2 weeks for 4 cycles followed by Paclitaxel 175 mg/m(2) IV, every 2 weeks for 4 cycles followed by Cyclophosphamide 600 mg/m(2) IV, every 2 weeks for 4 cycles Repeat every 14 days for 4 cycles Patients undergoing treatment with this regimen should receive primary prophylaxis for neutropenia [7].

BEP - Used for testicular cancer Bleomycin 30 units IV, days 2, 9, and 16 Etoposide 100 mg/m(2) IV, days 1 to 5 Cisplatin 20 mg/m(2) IV, days 1 to 5 Repeat cycle every 21 days

CAE (ACE) - Used for lung cancer, small cell Cyclophosphamide 1000 mg/m(2) IV, day 1 Doxorubicin 45 mg/m(2) IV, day 1 Etoposide 50 mg/m(2) IV, days 1 to 5 Repeat cycle every 21 days

CAF (FAC) - Used for breast cancer Cyclophosphamide 100 mg/m(2) ORALLY, days 1 to 14 OR 600 mg/m(2) IV, day 1 Doxorubicin 25 mg/m(2) IV, days 1 and 8 OR 60 mg/m(2) IV, day 1 Fluorouracil 500 to 600 mg/m(2) IV, days 1 and 8 Repeat cycle every 28 days OR Fluorouracil 500 mg/m(2) IV, days 1 and 8 Doxorubicin 50 mg/m(2) IV, day 1 Cyclophosphamide 500 mg/m(2) IV, day 1 Repeat cycle every 21 days [12][13][14]

Capecitabine + Docetaxel - Used for breast cancer Capecitabine 1250 mg/m(2) ORALLY 2 times/day, days 1 through 14 Docetaxel 75 mg/m(2) IV, day 1 Repeat cycle every 21 days [15]

CAPOX - Used for colon cancer Capecitabine 1000 mg/m(2) ORALLY 2 times a day, days 1 to 14 Oxaliplatin 70 mg/m(2) IV, day 8 Repeat cycle every 21 days

Carboplatin Etoposide - Used for lung cancer, non-small cell Carboplatin 100 mg/m(2) IV, days 1 through 3 Etoposide 120 mg/m(2) IV, days 1 through 3 Repeat cycle every 28 days OR Carboplatin 300 mg/m(2) IV, day 1 Etoposide 100 mg/m(2) IV, days 1 through 3 Repeat cycle every 21 days

Carboplatin Etoposide + Radiation therapy - Used for lung cancer, small cell Carboplatin AUC 6 IV over 1 hr, day 1; immediately followed by Etoposide 100 mg/m(2) IV over 2 hr, days 1 through 3 Repeat cycle every 21 days up to a total of 6 cycles Radiation therapy (XRT) 1.5 Gray (Gy) per fraction twice daily (at least 4 to 6 hr apart) up to a total of 45 Gy, either concurrently with the first cycle or concurrently with the fourth cycle of chemotherapy [16]

Carboplatin Irinotecan - Used for lung cancer, non-small cell Carboplatin AUC 5 mg/mL/min IV, day 1 Irinotecan 50 mg/m(2) IV, days 1, 8, and 15 Repeat cycle every 28 days [17]

Carbo-Tax - Used for adenocarcinoma of unknown primary Paclitaxel 135 mg/m(2) IV, over 24 hours, day 1, followed by Carboplatin dose targeted by Calvert formula to AUC 7.5 IV Repeat cycle every 21 days

Carbo-Tax - Used for ovarian cancer, epithelial or lung cancer, non-small cell Paclitaxel 135 mg/m(2) IV, over 24 hours, day 1 OR 175 mg/m(2) IV, over 3 hours, day 1 followed by Carboplatin dose targeted by Calvert formula to AUC of 7.5 IV Repeat cycle every 21 days

CAV (VAC) - Used for lung cancer, small cell Cyclophosphamide 750-1000 mg/m(2) IV, day 1 Doxorubicin 50 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (max 2 mg) IV, day 1 Repeat cycle every 21 days

CC - Used for ovarian cancer, epithelial Carboplatin dose targeted by Calvert formula to AUC of 6 to 7 IV, day 1 Cyclophosphamide 600 mg/m(2) IV, day 1 Repeat cycle every 28 days

CEF - Used for breast cancer Cyclophosphamide 75 mg/m(2)/day ORALLY on days 1 to 14 Epirubicin 60 mg/m(2)/day IV on days 1 and 8 5-fluorouracil 500 mg/m(2)/day IV on days 1 and 8 Repeat cycle every 28 days for 6 cycles [18]

CF - Used for head and neck/esophageal cancer Cisplatin 100 mg/m(2) IV, day 1 Fluorouracil 1000 mg/m(2)/day, continuous infusion, days 1 to 5 Repeat cycle every 21 to 28 days

CF - Used for head and neck/esophageal cancer Carboplatin 400 mg/m(2) IV, day 1 Fluorouracil 1000 mg/m(2)/day, continuous infusion, days 1 to 5 Repeat cycle every 21 to 28 days

CFM (CNF, FNC) - Used for breast cancer Cyclophosphamide 500 to 600 mg/m(2) IV, day 1 Fluorouracil 500 to 600 mg/m(2) IV, day 1 MitoXANTRONE 10 to 12 mg/m(2) IV, day 1 Repeat cycle every 21 days

ChlVPP - Used for Hodgkin's disease Chlorambucil 6 mg/m(2) ORALLY, days 1 to 14 VinBLAStine 6 mg/m(2) IV, days 1 and 8 Procarbazine 100 mg/m(2) ORALLY, days 1 to 14 Prednisone 40 mg/day ORALLY, days 1 to 14 Repeat cycle every 28 days

CHOP - Used for lymphoma, non-Hodgkin's Cyclophosphamide 750 mg/m(2) IV, day 1 Doxorubicin 50 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (max 2 mg) IV, day 1 Prednisone 100 mg/day ORALLY, days 1 to 5 Repeat cycle every 21 days

CISCA - Used for bladder cancer Cyclophosphamide 650 mg/m(2) IV, day 1 Doxorubicin 50 mg/m(2) IV, day 1 Cisplatin 70 to 100 mg/m(2) IV, day 2 Repeat cycle every 21 to 28 days

Cisplatin Vinorelbine - Used for lung cancer, non-small cell Cisplatin 50 mg/m(2) IV, days 1 and 8 Vinorelbine 25 mg/m(2) IV, one time weekly for 16 weeks Repeat cycle every 4 weeks for 4 cycles [19]

Cisplatin + Vinorelbine - Used for lung cancer, non-small cell Cisplatin 50 mg/m(2) IV, days 1 and 8 OR Cisplatin 100 mg/m(2) IV, day 1 only WITH Vinorelbine 25 mg/m(2) IV, one time weekly for 16 weeks OR Vinorelbine 30 mg/m(2) IV, one time weekly Repeat cycle every 4 weeks

Cisplatin Etoposide - Used for lung cancer, non-small cell Cisplatin 100 mg/m(2) IV, day 1 Etoposide 100 mg/m(2) IV, days 1 to 3 Repeat cycle every 4 weeks [20]

Cisplatin VinBLAStine - Used for lung cancer, non-small cell Cisplatin 80 mg/m(2) IV, day 1 VinBLAStine 4 mg/m(2) IV, 1 time weekly for 5 weeks (days 1 to 29 of cycle) VinBLAStine 4 mg/m(2) IV, every 2 weeks (day 43 of cycle until last cisplatin dose) [20]

CLD-BOMP - Used for cervical cancer Bleomycin 5 mg continuous infusion, days 1 to 7 Cisplatin 10 mg/m(2) IV, over 4 hours, days 1 and 22 Vincristine 0.7 mg/m(2) (max 2 mg) IV, day 7 Mitomycin 7 mg/m(2) IV, day 7 Repeat cycle every 21 days

CMF - Used for breast cancer Cyclophosphamide 100 mg/m(2) P0, days 1 to 14 Methotrexate 40 mg/m(2) IV, days 1 and 8 Fluorouracil 600 mg/m(2) IV, days 1 and 8 Repeat cycle every 28 days [21]

CMV - Used for bladder cancer Cisplatin 100 mg/m(2) IV, day 2 (12 hours after methotrexate) Methotrexate 30 mg/m(2) IV, days 1 and 8 VinBLAStine 4 mg/m(2) IV, days 1 and 8 Repeat cycle every 21 days

CNOP - Used for lymphoma, non-Hodgkin's Cyclophosphamide 750 mg/m(2) IV, day 1 MitoXANTRONE 10 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (max 2 mg) IV, day 1 Prednisone 50 mg/m(2) ORALLY, days 1 to 5 Repeat cycle every 21 days

COMLA - Used for lymphoma, non-Hodgkin's Cyclophosphamide 1500 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (max 2 mg) IV, days 1, 8, and 15 Methotrexate 120 mg/m(2) IV, days 22, 29, 36, 43, 50, 57, 64, and 71 Leucovorin 25 mg/m(2) ORALLY, every 6 hours for 4 doses beginning 24 hours after each methotrexate dose Cytarabine 300 mg/m(2) IV, days 22, 29, 36, 43, 50, 57, 64, and 71 Repeat cycle every 12 weeks

COP - Used for lymphoma, non-Hodgkin's Cyclophosphamide 800 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (max 2 mg) IV, day 1 Prednisone 60 mg/m(2) ORALLY, days 1 to 5 Repeat cycle every 14 days

CP - Used for ovarian cancer, epithelial Cyclophosphamide 750 mg/m(2) IV, day 1 Cisplatin 75 mg/m(2) IV, day 1 Repeat cycle every 21 days

CT - Used for ovarian cancer, epithelial Paclitaxel 135 mg/m(2) IV, over 24 hours, day 1 OR 175 mg/m(2) IV, over 3 hours, day 1 followed by Cisplatin 75 mg/m(2) IV Repeat cycle every 21 days

CVD - Used for melanoma Cisplatin 20 mg/m(2) IV, days 2 to 5 VinBLAStine 1.6 mg/m(2) IV, days 1 to 5 Dacarbazine 800 mg/m(2) IV, day 1 Repeat cycle every 21 days

CVD+IL-2 - Used for melanoma Cisplatin 20 mg/m(2) IV, days 1 to 4 VinBLAStine 1.6 mg/m(2) IV, days 1 to 4 Dacarbazine 800 mg/m(2) IV, day 1 IL-2, 9 million units/m(2) continuous infusion, days 1 to 4 Interferon alfa 5 million units/m(2) subQ, days 1 to 5, 7, 9, 11, and 13 Repeat cycle every 21 days

CYVADIC - Used for sarcoma Cyclophosphamide 500 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (max 2 mg) IV, days 1 and 5 Doxorubicin 50 mg/m(2) IV, day 1 Dacarbazine 250 mg/m(2) IV, days 1 to 5 Repeat cycle every 21 days

Dacarbazine Tamoxifen - Used for melanoma Dacarbazine 250 mg/m(2) IV, days 1 to 5, every 21 days Tamoxifen 20 mg/day ORALLY The use of tamoxifen is optional

DHAP - Used for lymphoma, non-Hodgkin's Dexamethasone 40 mg ORALLY or IV, days 1 to 4 Cisplatin 100 mg/m(2)/day, continuous infusion, day 1 Cytarabine 2000 mg/m(2) IV, every 12 hours for 2 doses, day 2 Administer with saline methylcellulose, or steroid eyedrops in both eyes, every 2 to 4 hours, beginning with cytarabine and continuing 48 to 72 hours after the last cytarabine dose. Repeat cycle every 21 to 28 days

DI - Used for sarcoma Doxorubicin 50 mg/m(2) IV, bolus, day 1 Ifosfamide 5000 mg/m(2)/day continuous infusion, following doxorubicin, day 1 Mesna 600 mg/m(2) IV, bolus before ifosfamide, followed by 2500 mg/m(2)/day continuous infusion, for 36 hours Repeat cycle every 21 days

Docetaxel Cisplatin - Used for lung cancer, non-small cell Docetaxel 75 mg/m(2) IV, day 1 Cisplatin 75 mg/m(2) IV, day 1 Repeat cycle every 3 weeks [22][23]

Docetaxel Estramustine - Used for prostate cancer Docetaxel 60 mg/m(2) IV, day 2 Estramustine 280 mg ORALLY, 3 times/day, days 1 through 5 Repeat cycle every 21 days [24][25][26]

Docetaxel Gemcitabine - Used for bladder cancer Docetaxel 40 mg/m(2) IV, days 1 and 8 Gemcitabine 800 mg/m(2) IV, days 1 and 8 Repeat cycle every 21 days [27]

Docetaxel Prednisone - Used for prostate cancer Docetaxel 30 mg/m(2) IV, days 1, 8, 15, 22, and 29 of a 6 week cycle OR Docetaxel 75 mg/m(2) IV, day 1; repeat every 21 days Prednisone 5 mg ORALLY, 2 times/day Repeat cycle every 21 days [28]

Docetaxel with Trastuzumab followed by FEC - Used for breast cancer Trastuzumab 4 mg/kg IV infuse over 90 min, once only with the first cycle of docetaxel THEN 2 mg/kg IV infuse over 30 min 1 times weekly for 9 weeks; infuse trastuzumab before docetaxel; no trastuzumab during FEC administration

Docetaxel 100 mg/m(2) IV over 1 hour, day 1 Repeat every 21 days for 3 cycles

After completion of 3 cycles of docetaxel and 9 weekly infusions of trastuzumab, begin 3 cycles of FEC

5-fluorouracil 600 mg/m(2) IV, day 1 Epirubicin 60 mg/m(2) IV, day 1 Cyclophosphamide 600 mg/m(2) IV, day 1 Repeat every 21 days for 3 cycles [29]

Sequential Dox-CMF - Used for breast cancer Four courses of doxorubicin followed by 8 courses of CMF for a total of 12 courses

Doxorubicin 75 mg/m(2) IV, day 1 Repeat every 21 days for 4 cycles

Start CMF after the fourth cycle of doxorubicin

Cyclophosphamide 600 mg/m(2) IV, day 1 Methotrexate 40 mg/m(2) IV, day 1 5-fluorouracil 600 mg/m(2) IV, day 1 Repeat every 21 days for 8 cycles [30]

EAP - Used for gastric cancer Etoposide 120 mg/m(2) IV, days 4, 5, and 6 Doxorubicin 20 mg/m(2) IV, days 1 and 7 Cisplatin 40 mg/m(2) IV, days 2 and 8 Repeat cycle every 21 to 28 days

EC - Used for breast cancer Epirubicin 100 mg/m(2) IV, day 1 Cyclophosphamide 830 mg/m(2) IV, day 1 Repeat cycle every 21 days [31]

Epirubicin 75 mg/m(2) IV, day 1; followed by Cyclophosphamide 600 mg/m(2) IV, day 1 Repeat cycle every 21 days for a maximum of 6 cycles [32]

EC - Used for lung cancer, non-small cell Etoposide 100 to 120 mg/m(2) IV, days 1 to 3 WITH Carboplatin 300 to 325 mg/m(2) IV, day 1 Repeat cycle every 21 to 28 days

EC - Used for lung cancer, small cell Etoposide 100 to 120 mg/m(2) IV, days 1 to 3 Carboplatin 325 to 450 mg/m(2) IV, day 1 Repeat cycle every 28 days

ELF - Used for gastric cancer Leucovorin 150 to 300 mg/m(2) IV, over 10 minutes FOLLOWED BY Etoposide 120 mg/m(2) IV, over 50 minutes FOLLOWED BY Fluorouracil 500 mg/m(2) IV, over 10 minutes All drugs are given on days 1 to 3 Repeat cycle every 21 to 28 days

EMA-86 - Used for acute myelogenous leukemia, induction Etoposide 200 mg/m(2)/day continuous infusion, days 8 to 10 MitoXANTRONE 12 mg/m(2) IV, days 1 to 3 Cytarabine 500 mg/m(2)/day continuous infusion, days 1 to 3 and 8 to 10

EP - Used for adenocarcinoma of unknown primary Cisplatin 60 to 100 mg/m(2) IV, day 1 Etoposide 80 to 100 mg/m(2) IV, days 1 to 3 Repeat cycle every 21 days

EP - Used for testicular cancer Etoposide 100 mg/m(2) IV, days 1 to 5 Cisplatin 20 mg/m(2) IV, days 1 to 5 Repeat cycle every 21 days

EP - Used for lung cancer, non-small cell Etoposide 80 mg/m(2) IV, days 1 to 3 Cisplatin 60 to 100 mg/m(2) IV, day 1 Repeat cycle every 21 to 28 days

EP (PE) - Used for lung cancer, small cell Etoposide 120 mg/m(2) IV, days 1 to 3 Cisplatin 60 to 120 mg/m(2) IV, day 1 Repeat cycle every 21 to 28 days

Sequential Epirubicin-CMF - Used for breast cancer Epirubicin 100 mg/m(2) IV, day 1, repeat every 21 days for 4 cycles CMF for 4 cycles . CMF regimen in the National Epirubicin Adjuvant Trial (NEAT) Cyclophosphamide 100 mg/m(2) ORALLY 1 times daily, days 1 through 14, OR 600 mg/m(2) IV on days 1 and 8 Methotrexate 40 mg/m(2) IV on day 1 and 8 5-Fluorouracil 600 mg/m(2) IV day 1 and 8 Repeat every 28 days for 4 cycles OR CMF regimen in the BR9601 trial Cyclophosphamide 750 mg/m(2) IV day 1 Methotrexate 50 mg/m(2) IV day 1 5-Fluorouracil 600 mg/m(2) IV days 1 Repeat every 21 days for 4 cycles [33]

ESHAP - Used for lymphoma, non-Hodgkin's Etoposide 60 mg/m(2) IV, days 1 to 4 Methylprednisolone 500 mg IV, days 1 to 4 Cisplatin 25 mg/m(2)/day continuous infusion, days 1 to 4 Cytarabine 2000 mg/m(2) IV, day 5, immediately following completion of etoposide and cisplatin infusions Administer with saline methylcellulose, or steroid eyedrops in both eyes, every 2 to 4 hours, beginning with cytarabine and continuing 48 to 72 hours after the last cytarabine dose. Repeat cycle every 21 to 28 days

Estramustine VinBLAStine - Used for prostate cancer Estramustine 200 mg/m(2) ORALLY, 3 times a day, days 1 to 42 VinBLAStine 4 mg/m(2) IV, weekly for 6 weeks, begin day 1 Repeat cycle every 6 weeks

Etoposide Cisplatin - Used for lung cancer, small cell Etoposide 100 mg/m(2) IV, day 1 Etoposide 200 mg/m(2) IV, days 2 through 4 Cisplatin 75 mg/m(2) IV, day 1 Repeat cycle every 21 days OR Etoposide 80 mg/m(2) IV, days 1 through 3 Cisplatin 80 mg/m(2) IV, day 1 Repeat cycle every 21 days [34]

EVA - Used for Hodgkin's disease Etoposide 100 mg/m(2) IV, days 1 to 3 VinBLAStine 6 mg/m(2) IV, day 1 Doxorubicin 50 mg/m(2) IV, day 1 Repeat cycle every 28 days

FAM - Used for gastric cancer Fluorouracil 600 mg/m(2) IV, days 1, 8, 29, and 36 Doxorubicin 30 mg/m(2) IV, days 1 and 29 Mitomycin C 10 mg/m(2) IV, day 1 Repeat cycle every 8 weeks

FAM - Used for adenocarcinoma of unknown primary Fluorouracil 600 mg/m(2) IV, over 1 hour, days 1, 8, 29, and 36 Doxorubicin 30 mg/m(2) IV, days 1 and 29 Mitomycin 10 mg/m(2) IV, day 1 Repeat cycle every 8 weeks

FAM - Used for pancreatic cancer Fluorouracil 600 mg/m(2) IV, days 1, 8, 29, and 36 Doxorubicin 30 mg/m(2) IV, days 1 and 29 Mitomycin 10 mg/m(2) IV, day 1 Repeat cycle every 72 days

FAMTX - Used for gastric cancer Methotrexate 1500 mg/m(2) IV, day 1 Fluorouracil 1500 mg/m(2) IV, starting 1 hour after methotrexate, day 1 Leucovorin 15 mg/m(2) ORALLY, every 6 hours, beginning 24 hours after methotrexate, continue until methotrexate concentration is less than 2 X 10(-8) (increase dose to 30 mg/m(2) if methotrexate concentration is greater than or equal to 2.5 X 10(-6) at 24 hours) Doxorubicin 30 mg/m(2) IV, day 15 Repeat cycle every 28 days

FC - Used for chronic lymphocytic leukemia Fludarabine 25 mg/m(2)/day IV over 3 days Cyclophosphamide 250 mg/m(2)/day IV over 3 days Repeat cycle every 28 days [35]

FEC - Used for breast cancer 5-fluorouracil 500 mg/m(2) IV, days 1 and 8 Epirubicin 50 mg/m(2) IV, days 1 and 8 Cyclophosphamide 400 mg/m(2) IV, days 1 and 8 Repeat cycle every 28 days [36]

FEC followed by T - Used for breast cancer 5-fluorouracil 500 mg/m(2) IV, day 1 Epirubicin 100 mg/m(2) IV, day 1 Cyclophosphamide 500 mg/m(2) IV, day 1 Docetaxel 100 mg/m(2) IV, day 1 Repeat every 21 days for 3 cycles [37]

FEC-100 - Used for breast cancer 5-fluorouracil 500 mg/m(2) IV on day 1 Epirubicin 100 mg/m(2) IV on day 1 Cyclophosphamide 500 mg/m(2) IV on day 1 Repeat cycle every 21 days for 6 cycles

FL - Used for prostate cancer Flutamide 250 mg ORALLY three times daily Leuprolide acetate 1 mg subQ daily OR Flutamide 250 mg ORALLY three times daily Leuprolide acetate depot 7.5 mg IM every 28 days

Fle - Used for colon cancer Fluorouracil 450 mg/m(2) IVP, days 1 to 5, then at day 29, begin 450 mg/m(2) IVP, every 7 days for a total of 1 year of therapy Levamisole 50 mg ORALLY, every 8 hours for 3 days, repeated every 14 days for 52 weeks [38]

FLOX- Used for colon cancer Oxaliplatin 85 mg/m(2) IV, infuse over 2 hr before leucovorin and fluorouracil on days 1, 15, and 29 Leucovorin 500 mg/m(2) infuse over 2 hr weekly on days 1, 8, 15, 22, 29, and 36 followed by a 2-week rest period Fluorouracil 500 mg/m(2) IV bolus 1 hr after the leucovorin is begun; weekly on days 1, 8, 15, 22, 29, and 36 followed by a 2-week rest period Three 8-week cycles of therapy for total treatment duration of 6 months [39]

Fluorouracil Leucovorin - Used for colon cancer Leucovorin 500 mg/m(2) IV, over 2 hours, 6 times weekly , followed by a 2-week rest period Fluorouracil 500 mg/m(2) IVP, 1 hour after initiating leucovorin infusion, 6 times weekly, followed by a 2-week rest period Repeat every 8 weeks for 4 cycles [38] OR Leucovorin 20 mg/m(2) IVP, days 1 to 5 Fluorouracil 425 mg/m(2) IVP, following leucovorin, days 1 to 5 Repeat cycle at 4 weeks, 8 weeks, and every 5 weeks for 6 courses [38] OR LV5FU2 Regimen Leucovorin 200 mg/m(2)/day as a 2-hour IV infusion, days 1 and 2 Fluorouracil 400 mg/m(2)/day IV bolus following leucovorin, days 1 and 2 Fluorouracil 600 mg/m(2)/day as a 22-hour infusion, days 1 and 2 Repeat every 2 weeks [40] OR Leucovorin 20 mg/m(2) IV over 2 hours Fluorouracil 500 mg/m(2) IV bolus one hour after leucovorin Repeat weekly [41]

Fluorouracil Leucovorin Bevacizumab - Used for colorectal cancer Fluorouracil 500 mg/m(2) IV once weekly for 6 weeks Leucovorin 500 mg/m(2) IV every 8 weeks Bevacizumab 5 mg/kg IV every 2 weeks [42]

Fluorouracil Leucovorin Levamisole - Used for colon cancer Fluorouracil 425 mg/m(2) IVP days 1 to 5 Leucovorin 20 mg/m(2) IVP days 1 to 5 Repeat ever 4 weeks, 8 weeks, and every 5 weeks for 6 courses; administer with Levamisole 50 mg ORALLY, every 8 hours for 3 days, repeated every 14 days for 6 months [38]

FOLFIRI - Used for colorectal cancer Irinotecan 180 mg/m(2) IV, day 1; with Fluorouracil 400 mg/m(2) bolus; and Fluorouracil 600 mg/m(2) by 22 hr infusion; plus Leucovorin 400 mg/m(2) IV days 1 and 2 Repeat every 2 weeks until disease progression or intolerable toxicity [43]

Alternative regimen: Irinotecan 180 mg/m(2) IV over 90 minutes, day 1 Leucovorin 400 mg/m(2) IV over 2 hours during irinotecan, day 1 Fluorouracil 400 mg/m(2) IV bolus followed by Fluorouracil 2.4 g/m(2) (first 2 cycles) to 3 g/m(2) (subsequent cycles) IV over 46 hours continuous infusion Repeat every 2 weeks until disease progression or intolerable toxicity [44]

FOLFIRINOX - Used for metastatic pancreatic cancer Oxaliplatin 85 mg/m(2) IV over 2 hours, immediately followed by Leucovorin 400 mg/m(2) IV over 2 hours Irinotecan 180 mg/m(2) IV over 90 minutes through a Y-connector (30 minutes after leucovorin), immediately followed by Fluorouracil 400 mg/m(2) IV bolus followed by Fluorouracil 2.4 g/m(2) IV over 46 hours continuous infusion Repeat every 2 weeks for 6 months [45]

FOLFOX 4 - Used for colorectal cancer Oxaliplatin 85 mg/m(2) IV over 2 hours, day 1, same time as leucovorin (different lines) Leucovorin 200 mg/m(2)/day or l-leucovorin 100 mg/m(2) IV over 2 hours, days 1 and 2, before fluorouracil on each day Fluorouracil 400 mg/m(2)/day IV bolus, days 1 and 2, followed by Fluorouracil 600 mg/m(2)/day as a continuous IV infusion over 22 hours, days 1 and 2 Repeat every 2 weeks [46][47]

FOLFOX 6 - Used for colorectal cancer Oxaliplatin 100 mg/m(2) IV over 2 hours, day 1, same time as leucovorin (different lines) Leucovorin 400 mg/m(2) or l-leucovorin 200 mg/m(2) IV over 2 hours, day 1, before fluorouracil on day 1 Fluorouracil 400 mg/m(2) IV bolus once on day 1 only followed by Fluorouracil 2.4 to 3 g/m(2)* as a continuous IV infusion over 46 hours Repeat every 2 weeks [48][49]

• 2.4 g/m(2) for the first 2 cycles, increased to 3 g/m(2) thereafter if no toxicity greater than grade 1 [48]

Modified FOLFOX 6 - Used for colorectal cancer Oxaliplatin 85 mg/m(2) IV over 2 hours, day 1, same time as leucovorin (different lines) Leucovorin 400 mg/m(2) or l-leucovorin 200 mg/m(2) IV over 2 hours, day 1, before fluorouracil on day 1 Fluorouracil 400 mg/m(2) IV bolus once on day 1 only followed by Fluorouracil 2.4 g/m(2) as a continuous IV infusion over 46 or 48 hours Repeat every 2 weeks [50][51]

FOLFOX 7 - Used for colorectal cancer Oxaliplatin 130 mg/m(2) IV over 2 hours, day 1, same time as leucovorin (different lines) Leucovorin 400 mg/m(2) or l-leucovorin 200 mg/m(2) IV over 2 hours, day 1, before fluorouracil on day 1 Fluorouracil 2.4 g/m(2) as a continuous IV infusion over 46 hours Repeat every 2 weeks [46]

FZ - Used for prostate cancer Flutamide 250 mg ORALLY, 3 times/day Goserelin acetate 3.6-mg implant subQ every 28 days OR Flutamide 250 mg ORALLY, 3 times/day Goserelin acetate 10.8-mg implant subQ every 12 weeks

GC - Used for bladder cancer Gemcitabine 1000 mg/m(2) IV, days 1, 8, and 15 Cisplatin 70 mg/m(2) IV, day 2 Repeat cycle every 28 days

GDP - Used for lymphoma, non-Hodgkin's Gemcitabine 1000 mg/m(2) IV over 30 minutes, days 1 and 8 Dexamethasone 40 mg ORALLY in divided doses, days 1 through 4 Cisplatin 75 mg/m(2) IV over 60 minutes, day 1 Repeat cycle every 21 days [52]

Gemcitabine-Cis - Used for lung cancer, non-small cell Gemcitabine 1000 mg/m(2) IV, days 1, 8, and 15 Cisplatin 100 mg/m(2) IV, day 2 or 15 Repeat cycle every 28 days

Gemcitabine Paclitaxel - Used for bladder cancer Gemcitabine 1000 mg/m(2) IV, days 1, 8, and 15 Paclitaxel 200 mg/m(2) IV, day 1 Repeat cycle every 21 days [53]

GT - Used for breast cancer Paclitaxel 175 mg/m(2) IV, day 1 Gemcitabine 1250 mg/m(2) IV, days 1 and 8 Repeat cycle every 21 days [54]

ICE - Used for lymphoma, non-Hodgkin's Regimen # 1 Etoposide 100 mg/m(2) IV bolus, days 1 to 3 Carboplatin AUC 5, MAX 800 mg, IV bolus on day 2 Ifosfamide 5000 mg/m(2), admixed with mesna 5000 mg/m(2), IV continuous infusion over 24 hours on day 2 Filgrastim (G-CSF) 5 mcg/kg/day, days 5 to 12 for cycles 1 and 2, then 10 mcg/kg/day after the third cycle until the end of leukapheresis Repeat cycle every 14 days for 3 cycles [55]

Regimen # 2 Ifosfamide 1000 mg/m(2)/day over 1 hour days 1 to 2 (hours 0 and 1) Etoposide 150 mg/m(2)/day IV over 11 hours after ifosfamide days 1 to 2 (hours 1 to 11) Carboplatin 200 mg/m(2)/day IV over 1 hour after etoposide days 1 to 2 (hours 11 to 12) Etoposide 150 mg/m(2)/day IV over 11 hours after carboplatin days 1 to 2 (hours 12 to 24) Mesna 333 mg/m(2) IV 30 minutes before ifosfamide, repeat 4 and 8 hours after ifosfamide Repeat cycle every 4 weeks for 2 cycles[56]

IE - Used for sarcoma Etoposide 100 mg/m(2) IV, days 1 to 5 Ifosfamide 1800 mg/m(2) IV, days 1 to 5 Mesna at 20% of ifosfamide dose prior to and 4 and 8 hours after ifosfamide administration Repeat cycle every 21 to 28 days

IFL - Used for colorectal cancer Irinotecan 125 mg/m(2) IV Fluorouracil 500 mg/m(2) IV bolus plus Leucovorin 20 mg/m(2) IV on Days 1, 8, 15, and 22 every 6 weeks

IFL Bevacizumab - Used for colorectal cancer Irinotecan 125 mg/m(2) IV once weekly for 4 weeks Fluorouracil 500 mg/m(2) IV every 6 weeks Leucovorin 20 mg/m(2) IV Bevacizumab 5 mg/kg IV every 2 weeks [42]

Irinotecan Cisplatin - Used for lung cancer, small cell Irinotecan 60 mg/m(2) IV, days 1, 8, and 15 Cisplatin 60 mg/m(2) IV, day 1 Repeat cycle every 28 days OR Irinotecan 65 mg/m(2) IV, days 1 and 8 Cisplatin 30 mg/m(2) IV, days 1 and 8 Repeat cycle every 21 days [57]

IROX - Used for colorectal cancer Oxaliplatin 85 mg/m(2) IV Irinotecan 200 mg/m(2) IV Repeat every 3 weeks

Ixabepilone + Capecitabine - Used for breast cancer Ixabepilone 40 mg/m(2) IV, day 1 Capecitabine 1000 mg/m(2) ORALLY 2 times/day, days 1 through 14 Repeat cycle every 21 days [58]

Lapatinib + Capecitabine - Used for breast cancer Lapatinib 1250 mg ORALLY, days 1 through 21 Capecitabine 1000 mg/m(2) ORALLY 2 times/day, days 1 through 14 Repeat cycle every 21 days [59]

M2 - Used for multiple myeloma Vincristine 0.03 mg/kg (max 2 mg) IV, day 1 Carmustine 0.5 to 1 mg/kg IV, day 1 Cyclophosphamide 10 mg/kg IV, day 1 Melphalan 0.25 mg/kg ORALLY, days 1 to 4 OR 0.1 mg/kg ORALLY, days 1 to 7 or 1 to 10 Prednisone 1 mg/kg/day ORALLY, days 1 to 7 Repeat cycle every 35 to 42 days

MACOP-B - Used for lymphoma, non-Hodgkin's Methotrexate 400 mg/m(2) IV, weeks 2, 6, and 10 Leucovorin 15 mg/m(2) ORALLY, every 6 hours for 6 doses, beginning 24 hours after methotrexate Doxorubicin 50 mg/m(2) IV, weeks 1, 3, 5, 7, 9, and 11 Cyclophosphamide 350 mg/m(2) IV, weeks 1, 3, 5, 7, 9, and 11 Vincristine 1.4 mg/m(2) (max 2 mg) IV, weeks 2, 4, 6, 8, 10, and 12 Prednisone 75 mg/day ORALLY, for 12 weeks, then taper over last 2 weeks Bleomycin 10 units/m(2) IV, weeks 4, 8, and 12 Cotrimoxazole DS ORALLY, 2 times/day for 12 weeks Ketoconazole 200 mg/day ORALLY Administer 1 cycle

MAID - Used for sarcoma Mesna 2500 mg/m(2)/day continuous infusion, days 1 to 4 Doxorubicin 15 mg/m(2)/day continuous infusion, days 1 to 4 Ifosfamide 2500 mg/m(2)/day continuous infusion, days 1 to 3 Dacarbazine 250 mg/m(2)/day continuous infusion, days 1 to 4 Repeat cycle every 21 to 28 days

m-BACOD - Used for lymphoma, non-Hodgkin's Methotrexate 200 mg/m(2) IV, days 8 and 15 Leucovorin 10 mg/m(2) ORALLY, every 6 hours for 8 doses, beginning 24 hours after each methotrexate dose Bleomycin 4 units/m(2) IV, day 1 Doxorubicin 45 mg/m(2) IV, day 1 Cyclophosphamide 600 mg/m(2) IV, day 1 Vincristine 1 mg/m(2) (max 2 mg) IV, day 1 Dexamethasone 6 mg/m(2) ORALLY, days 1 to 5 Repeat cycle every 21 days

MINE-ESHAP - Used for lymphoma, non-Hodgkin's Mesna 1330 mg/m(2) IV, given at the same time as ifosfamide, then 500 mg ORALLY, 4 hours after ifosfamide, days 1 to 3 Ifosfamide 1330 mg/m(2) IV, over 1 hour, days 1 to 3 MitoXANTRONE 8 mg/m(2) IV, day 1 Etoposide 65 mg/m(2) IV, days 1 to 3 Repeat cycle every 21 days for 6 cycles, followed by 3 to 6 cycles of ESHAP

MitoXANTRONE Prednisone - Used for prostate cancer MitoXANTRONE 12 mg/m(2) IV, day 1 Prednisone 5 mg ORALLY, 2 times/day Repeat cycle every 21 days

MOBP - Used for cervical cancer Bleomycin 30 units/day continuous infusion, days 1 and 4 Vincristine 0.5 mg/m(2) (max 2 mg) IV, days 1 and 4 Mitomycin 10 mg/m(2) IV, day 1 Cisplatin 50 mg/m(2) IV, days 1 and 22 Repeat cycle every 28 days

MOPP - Used for Hodgkin's disease, adult Mechlorethamine 6 mg/m(2) IV, days 1 and 8 Vincristine 1.4 mg/m(2) (max 2 mg) IV, days 1 and 8 Procarbazine 100 mg/m(2) ORALLY, days 1 to 14 Prednisone 40 mg/m(2) ORALLY, days 1 to 14 Repeat cycle every 28 days

MOPP/ABV Hybrid - Used for Hodgkin's disease Mechlorethamine 6 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (max 2 mg) IV, day 1 Procarbazine 100 mg/m(2) ORALLY, days 1 to 7 Prednisone 40 mg/m(2) ORALLY, days 1 to 14 Doxorubicin 35 mg/m(2) IV, day 8 Bleomycin 10 units/m(2) IV, day 8 VinBLAStine 6 mg/m(2) IV, day 8 Repeat cycle every 28 days

MOPP/ABVD - Used for Hodgkin's disease Refer to MOPP doses; alternate every other month with ABVD

MP - Used for multiple myeloma Melphalan 8 to 10 mg/m(2) ORALLY, days 1 to 4 Prednisone 40 to 60 mg/m(2)/d ORALLY, days 1 to 4 Repeat cycle every 28 to 42 days

MVAC - Used for bladder cancer Methotrexate 30 mg/m(2) IV, days 1, 15, and 22 VinBLAStine 3 mg/m(2) IV, days 2, 15, and 22 Doxorubicin 30 mg/m(2) IV, day 2 Cisplatin 70 mg/m(2) IV, day 2 Repeat cycle every 28 days

NFL - Used for breast cancer MitoXANTRONE 12 mg/m(2) IV, day 1 Fluorouracil 350 mg/m(2) IV, days 1 to 3 following leucovorin Leucovorin 300 mg IV, over 1 hour, days 1 to 3 OR MitoXANTRONE 10 mg/m(2) IV, day 1 Fluorouracil 1000 mg/m(2)/day as continuous infusion, days 1 to 3, following leucovorin Leucovorin 100 mg/m(2) IV, over 15 minutes, days 1 to 3 Repeat cycle every 21 days

NOVP - Used for lymphoma, non-Hodgkin's MitoXANTRONE 10 mg/m(2) IV, day 1 VinBLAStine 6 mg/m(2) IV, day 1 Prednisone 100 mg ORALLY, days 1 to 5 Vincristine 2 mg IV, day 8 Repeat cycle every 21 days

P + T followed by FEC + T - Used for breast cancer Trastuzumab 4 mg/kg IV infuse over 90 minutes on day 1 with the first cycle of paclitaxel, THEN 2 mg/kg IV infuse over 30 minutes once a week starting with week 2 and for the duration of the 24 weeks of chemotherapy

Paclitaxel 225 mg/m(2) IV infuse over 24 hours, day 1 Repeat every 21 days for 4 cycles

After completion of 4 cycles of paclitaxel, begin 4 cycles of FEC

5-fluorouracil 500 mg/m(2) IV, days 1 and 4 Epirubicin 75 mg/m(2) IV, day 1 only Cyclophosphamide 500 mg/m(2) IV, day 1 only Repeat every 21 days for 4 cycles [60]

PAC - Used for bladder cancer Cisplatin 100 mg/m(2) IV Doxorubicin 60 mg/m(2) IV Cyclophosphamide 600 mg/m(2) IV Repeat cycle every 4 weeks [61]

Paclitaxel Cisplatin - Used for lung cancer, non-small cell Paclitaxel 135 mg/m(2) IV, day 1 Cisplatin 75 mg/m(2) IV, day 2 Repeat cycle every 3 weeks [23]

Paclitaxel Carboplatin - Used for lung cancer, non-small cell Adjuvant Paclitaxel 200 mg/m(2) IV, day 1 Carboplatin AUC 6 mg/mL/min IV, day 1 Repeat cycle every 3 weeks [62] Advanced Paclitaxel 225 mg/m(2) IV, infuse over 3 hours, day 1 Carboplatin AUC 6 mg/mL/min IV, day 1 Repeat cycle every 3 weeks for 4 cycles [23][63]

Paclitaxel Carboplatin Etoposide - Used for adenocarcinoma of unknown primary Paclitaxel 200 mg/m(2) IV, over 1 hour, day 1 Carboplatin dose targeted by Calvert formula to AUC 6 IV Etoposide 50 mg/day ORALLY alternated with 100 mg/day ORALLY, days 1 to 10 Repeat cycle every 21 days

Paclitaxel Trastuzumab - Used for breast cancer Paclitaxel 175 mg/m(2) IV, day 1 Trastuzumab 4 mg/kg IV, given at the same time as paclitaxel, then 2 mg/kg IV, 1 times weekly Repeat cycle every 21 days [64]

PC - Used for bladder cancer Paclitaxel 200 mg/m(2) or 225 mg/m(2) IV, over 3 hours, day 1 Carboplatin targeted by Calvert formula to AUC 5 to 6 IV after paclitaxel, day 1 Repeat cycle every 21 days

PC - Used for lung cancer, non-small cell Paclitaxel 175 mg/m(2) IV, over 3 hours, day 1 Cisplatin 80 mg/m(2) IV, day 1 Repeat cycle every 21 days

PE - Used for prostate cancer Paclitaxel 120 mg/m(2) continuous infusion, days 1 to 4 Estramustine 600 mg/day ORALLY, in 2 or 3 divided doses, 24 hours before paclitaxel Repeat cycle every 21 days

PE + Radiation therapy - Used for lung cancer, non-small cell Cisplatin 50 mg/m(2) IV on days 1, 8, 29, and 36, with Etoposide 50 mg/m(2) IV on days 1 through 5 and 29 through 33 Radiation therapy (XRT) 1.8 Gray (Gy) per fraction 5 days a week for a total of 25 fractions (45 Gy) to the primary and mediastinum; followed by XRT 1.8 Gy per fraction once daily in 8 fractions (14.4 Gy) to the primary and involved nodes for a total of 59.4 Gy in 33 fractions [65]

ProMACE/cytaBOM - Used for lymphoma, non-Hodgkin's Prednisone 60 mg/m(2) ORALLY, days 1 to 14 Doxorubicin 25 mg/m(2) IV, day 1 Cyclophosphamide 650 mg/m(2) IV, day 1 Etoposide 120 mg/m(2) IV, day 1 Cytarabine 300 mg/m(2) IV, day 8 Bleomycin 5 units/m(2) IV, day 8 Vincristine 1.4 mg/m(2) (max 2 mg) IV, day 8 Methotrexate 120 mg/m(2) IV, day 8 Leucovorin 25 mg/m(2) ORALLY, every 6 hours for 6 doses, beginning 24 hours after methotrexate Concomitant Cotrimoxazole DS ORALLY 2 times/day Repeat cycle every 21 to 28 days

PVB - Used for testicular cancer Cisplatin 20 mg/m(2) IV, days 1 to 5 VinBLAStine 0.15 mg/kg IV, days 1 and 2 Bleomycin 30 units IV, days 2, 9, and 16 Repeat cycle every 21 days

R-CHOP - Used for lymphoma, non-Hodgkin's Rituximab 375 mg/m(2) IV, day 1 Cyclophosphamide 750 mg/m(2) IV, day 1 Doxorubicin 50 mg/m(2) IV, day 1 Vincristine 1.4 mg/m(2) (MAX 2 mg) IV, day 1 PredniSONE 40 mg/m(2)/day ORALLY, days 1 to 5 Repeat cycle every 3 weeks for 8 cycles [66]

RICE - Used for lymphoma, non-Hodgkin's Rituximab 375 mg/m(2) IV day 1 of each cycle and 48 hr before first cycle initiation Ifosfamide 5000 mg/m(2) with equal amount of mesna continuous IV infusion over 24 hr beginning day 4 Carboplatin AUC 5, capped at 800 mg, bolus infusion on day 4 Etoposide 100 mg/m(2) IV bolus daily for 3 days, on days 3 to 5 Repeat cycle every 14 days for 3 cycles G-CSF 5 mcg/kg subQ days 7 to 14 after the first 2 cycles and 10 mcg/kg/day after the third cycle until the end of leukapheresis [67]

SMF - Used for pancreatic cancer Streptozocin 1000 mg/m(2) IV, days 1, 8, 29, and 36 Mitomycin 10 mg/m(2) IV, day 1 Fluorouracil 600 mg/m(2) IV, days 1, 8, 29, and 36 Repeat cycle every 72 days

Stanford V - Used for Hodgkin's disease Mechlorethamine 6 mg/m(2) IV, day 1 Doxorubicin 25 mg/m(2) IV, days 1 and 15 VinBLAStine* 6 mg/m(2) IV, days 1 and 15 Vincristine* 1.4 mg/m(2) (max 2 mg) IV, days 8 and 22 Bleomycin 5 units/m(2) IV, days 8 and 22 Etoposide 60 mg/m(2) IV, days 15 and 16 Prednisone 40 mg/m(2) ORALLY, every other day, taper by 10 mg every other day starting at week 10 Repeat cycle every 28 days

• In patients over 50 years old, decrease the vinBLAStine dose to 4 mg/m(2) and the vincristine dose to 1 mg/m(2) on weeks 9 to 12.

Concomitant Cotrimoxazole DS ORALLY 2 times/day; acyclovir 200 mg ORALLY 3 times/day; ketoconazole 200 mg ORALLY daily and stool softeners used.

TAC - Used for breast cancer Doxorubicin 50 mg/m(2) IV, day 1 Cyclophosphamide 500 mg/m(2) IV, day 1 Docetaxel 75 mg/m(2) IV, day 1, one hour after cyclophosphamide Repeat cycle every 21 days [68]

TAP - Used for endometrial cancer[11] Doxorubicin 45 mg/m(2) IV, day 1 Cisplatin 50 mg/m(2) IV, day 1 Paclitaxel 160 mg/m(2) IV over 3 hours, day 2 Filgrastim 5 mcg/kg/day subQ, days 3 to 12 Repeat cycle every 21 days for up to 7 cycles

TC - Used for breast cancer Docetaxel 75 mg/m(2) IV, day 1 Cyclophosphamide 600 mg/m(2) IV, day 1 Repeat every 21 days for 4 cycles [69]

TCH (Paclitaxel/Carboplatin weekly + Trastuzumab) - Used for breast cancer Paclitaxel 80 mg/m(2) IV over 1 hour, days 1, 8, and 15; followed by Carboplatin AUC 2 mg/mL/min IV over 15 min, days 1, 8, and 15 Repeat every 28 days (4-week cycle) for 6 cycles

PLUS

Trastuzumab 4 mg/kg IV over 90 minutes on day 1 of cycle 1; followed by Trastuzumab 6 mg/kg IV over 90 minutes every 21 days beginning with cycle 2 until disease progression [70][10]

TIP - Used for head and neck/esophageal cancer Paclitaxel 175 mg/m(2) IV, over 3 hours, day 1 Ifosfamide 1000 mg/m(2) IV, over 2 hours, days 1 to 3 Mesna 400 mg/m(2) IV, before ifosfamide and 200 mg/m(2) IV, 4 hours after ifosfamide Cisplatin 60 mg/m(2) IV, day 1 Repeat cycle every 21 to 28 days

TPC - Used for breast cancer Cycle 1 Trastuzumab 4 mg/kg IV, day 1 Paclitaxel 175 mg/m(2) IV, day 2 Carboplatin AUC 6 mg/mL/min IV, day 2 Trastuzumab 2 mg/kg IV, days 8, 15

Cycles 2 through 6 Trastuzumab 2 mg/kg IV, days 1, 8, and 15 Paclitaxel 175 mg/m(2) IV, day 2 Carboplatin AUC 6 mg/mL/min IV, day 2 Repeat every 21 days for at least 6 cycles

After chemotherapy Trastuzumab 2 mg/kg/week IV until disease progression or other discontinuation event [71]

VAD - Used for multiple myeloma Vincristine 0.4 mg/day (max 2 mg) continuous infusion, days 1 to 4 Doxorubicin 9 mg/m(2)/day continuous infusion, days 1 to 4 Dexamethasone 40 mg ORALLY, days 1 to 4, 9 to 12, and 17 to 20 Repeat cycle every 25 to 35 days VAD induction therapy followed by maintenance with Interferon alfa 3 million units subQ 3 times/week in the evening followed by Prednisone 50 mg ORALLY, 3 times/week on the morning after interferon

VATH - Used for breast cancer VinBLAStine 4.5 mg/m(2) IV, day 1 Doxorubicin 45 mg/m(2) IV, day 1 Thiotepa 12 mg/m(2) IV, day 1 Fluoxymesterone 10 mg ORALLY 3 times/day Repeat cycle every 21 days

VBMCP - Used for multiple myeloma Vincristine 1.2 mg/m(2) (max 2 mg) IV, day 1 Carmustine 20 mg/m(2) IV, day 1 Melphalan 8 mg/m(2) ORALLY, days 1 to 4 Cyclophosphamide 400 mg/m(2) IV, day 1 Prednisone 40 mg/m(2) ORALLY, days 1 to 7 Repeat cycle every 35 days [72]

VBMCP/VBAD/B - Used for multiple myeloma Vincristine 0.03 mg/kg (max 2 mg) IV, day 1 Carmustine 0.5 mg/kg IV, day 1 Melphalan 0.25 mg/kg ORALLY, days 1 to 4 Cyclophosphamide 10 mg/kg IV, day 1 [73] Prednisone 1 mg/kg ORALLY on days 1 to 4, 0.5 mg/kg ORALLY on days 5 to 8, and 0.25 mg/kg ORALLY on days 9 to 12 Cycle length is 35 days Vincristine 1 mg IV, day 1 Carmustine 30 mg/m(2) IV, day 1 Doxorubicin 40 mg/m(2) IV, day 1 Dexamethasone 40 mg ORALLY, days 1 to 4, 9 to 12, and 17 to 20 Alternate courses at 5-week intervals for 4 cycles [74], then Bortezomib 1.3 mg/m(2) IV, days 1, 4, 8, and 11 at 3-week intervals for 2 courses as induction therapy Low-molecular weight heparin or aspirin thromboprophylaxis recommended [75]

VTD - Used for multiple myeloma Bortezomib 1.3 mg/m(2) IV, days 1, 4, 8, and 11 Thalidomide 50 mg ORALLY on days 1 to 14, and 100 mg ORALLY on days 15 to 28 of cycle 1, then 200 mg ORALLY daily Dexamethasone 40 mg ORALLY, days 1 to 4 and 9 to 12 Cycle length is 4 weeks, repeat for 6 cycles as induction therapy Low-molecular weight heparin or aspirin thromboprophylaxis recommended [75]

Vinorelbine Cis - Used for lung cancer, non-small cell Vinorelbine 30 mg/m(2) IV, every 7 days Cisplatin 120 mg/m(2) IV, day 1 and 29, then every 6 weeks

Vinorelbine Doxorubicin - Used for breast cancer Vinorelbine 25 mg/m(2) IV, days 1 and 8 Doxorubicin 50 mg/m(2) IV, day 1 Repeat cycle every 21 days

Vinorelbine Trastuzumab - Used for breast cancer Trastuzumab 4 mg/kg IV, day 1, then 2 mg/kg IV, 1 times weekly Vinorelbine 25 mg/m(2) IV, 1 times weekly on same day as trastuzumab [76]

VIP - Used for testicular cancer VinBLAStine 0.11 mg/kg IV, days 1 and 2 OR Etoposide 75 mg/m(2) IV, days 1 to 5 AND Ifosfamide 1200 mg/m(2) IV, days 1 to 5 Cisplatin 20 mg/m(2) IV, days 1 to 5 Mesna 400 mg IV, 15 minutes prior to ifosfamide, then 1200 mg/day continuous infusion, days 1 to 5 Repeat cycle every 21 days

XELOX - Used for colon cancer Capecitabine 1000 mg/m(2) ORALLY 2 times a day, days 1 to 14 Oxaliplatin 130 mg/m(2) IV over 2 hours, day 1 Repeat cycle every 21 days [77]