Sandbox:classification 1

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  • Hairy cell leukemia may be classified into two subtypes: Hairy cell leukemia (classic) and hairy cell leukemia variant.[1]
  • Hairy cell leukemia variant is still considered a provisional entity at this time, as the WHO is unable to recognize it as distinct diseases due to insufficient evidence.[2]
  • The algorithm below illustrates characteristic findings associated with each subtypes:[3]
 
 
 
 
 
 
 
Hairy cell leukemia classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Hairy cell leukemia
 
 
 
 
 
Hairy cell leukemia variant
 
 
 
 
 
 
 
 
 
  • Occurs in approximately 95% of the cases
  • The male to female ratio is approximately 4 to 1
  • The median age at diagnosis is 55 years
  • Less than 10% lymphocytosis on peripheral blood smear
  • Decreased level of monocyte on peripheral blood smear
  • Decreased hemoglobin level in approximately 85% of the patients
  • Thrombocytopenia is present in approximately 80% of the patients
  • CD103+, CD11c+, and CD25+ on immunophenotype
  • DBA.44+, Cyclin D1+, and Annexin A1+ on immunohistochemistry
  • Presence of BRAF V600E mutation on cytogenetic tests
 
 
 
 
 
  • Occurs in approximately 5% of the cases
  • The male to female ratio is approximately 2 to 1
  • The median age at diagnosis is greater than 70 years
  • greater than 90% lymphocytosis on peripheral blood smear
  • Normal level of monocyte on peripheral blood smear
  • Normal hemoglobin level in most of the patients
  • Normal platelets count in most of the patients
  • CD103+, CD11c+, and CD25- on immunophenotype
  • DBA.44+, Cyclin D1+, and Annexin A1- on immunohistochemistry
  • Presence of BRAF wild type mutation on cytogenetic tests
 
 
 
 
 
 
 
 




The median age at diagnosis is 55 years.

  1. ↑ Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Classification Accessed on October, 17 2015
  2. ↑ Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES (2011). "The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications". Blood. 117 (19): 5019–32. doi:10.1182/blood-2011-01-293050. PMC 3109529. PMID 21300984.
  3. ↑ Matutes E (2006). "Immunophenotyping and differential diagnosis of hairy cell leukemia". Hematol Oncol Clin North Am. 20 (5): 1051–63. doi:10.1016/j.hoc.2006.06.012. PMID 16990106.
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