Sandbox:algorthim

Initial patients evaluation

History Physical examination Complete blood count

Staging

Rai Staging System Binet Staging System

Rai stage 0-2 Binet stage A

Rai stage 3-4 Binet stage B-C

Patients managed by observation and close follow-up

Evaluate patients by Cumulative Index Illness Rating Scale

Fit patients (CIRS <6)

Frail patients (CIRS ≥6)

FISH chromosomal analysis

Obinutuzumab AND chlorambucil Ofatumumab AND chlorambucil Rituximab AND chlorambucil

Immunochemotherapeutic regimens for the management of patients without chromosome 17p deletion or chromosome 11q deletion can be found here

Immunochemotherapeutic regimens for the management of patients with chromosome 17p deletion can be found here

Immunochemotherapeutic regimens for the management of patients with chromosome 11q deletion can be found here