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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
| Differentiating features | Leukemia | Leukemoid reaction |
|---|---|---|
| Causes | Carcinogens | Infectious agents, biologically active substances and
products of tissue destruction |
| Pathogenesis | The transformation of normal haematopoietic
cells to a tumor |
Activation of normal hematopoiesis and exit of immature leukocytes
into the bloodstream. |
| Duration | Chronic | Temporary and reversible |
| Genetic level | Defect | No defect |
| Splenomegaly | Present | Not present |
| Peripheral blood | Immature cells, pancytopenia | Mature and immature granulocytes with left shift |
| Bone marrow | Increase in blasts and immature cells | Myeloid hyperplasia and normal morphology |
| LAP score | Low | High |
Toxic granules
(suggestive of infection) |
Absent | Present |
| Dohle inclusion bodies | Absent | Present |