SREBP cleavage activating protein

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SREBF chaperone
Identifiers
SymbolSCAP
Entrez22937
HUGO30634
OMIM601510
RefSeqNM_012235
UniProtQ12770
Other data
LocusChr. 3 p21.31

SREBP cleavage-activating protein (SCAP) is regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element binding protein (SREBP). SCAP is an integral membrane protein located in the endoplasmic reticulum (ER).[1]

References

  1. Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc Natl Acad Sci U S A. 96 (20): 11041–8. PMID 10500120.

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