SIGLEC10

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.[1][2] The mouse orthologue is Siglec G.

Structure and Function

Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab.[3] It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

Gene Family summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM][2]

References

  1. Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR (Apr 2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor". Biochem J. 355 (Pt 2): 489–97. doi:10.1042/0264-6021:3550489. PMC 1221762. PMID 11284738.
  2. 2.0 2.1 "Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10".
  3. Clark, M. & A. Cooke (2013). "Regulation unmasked by activation". Nat Immunol. 14: 696–697. doi:10.1038/ni.2646.

Further reading




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