SH3KBP1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85, in rodents - Ruk) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.

Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]

Interactions

SH3KBP1 has been shown to interact with B-cell linker, Grb2, SH3GLB2, SH3GL3, SH3GL2, BCAR1, Epidermal growth factor receptor, CBLB, Cbl gene, SOS1, CRK and PAK2.

Further reading

• Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D (March 1998). "Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN". The Journal of Biological Chemistry. 273 (12): 6989–97. doi:10.1074/jbc.273.12.6989. PMID 9507006.
• Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (December 1998). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". The EMBO Journal. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.
• Take H, Watanabe S, Takeda K, Yu ZX, Iwata N, Kajigaya S (February 2000). "Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl". Biochemical and Biophysical Research Communications. 268 (2): 321–8. doi:10.1006/bbrc.2000.2147. PMID 10679202.
• Chen B, Borinstein SC, Gillis J, Sykes VW, Bogler O (June 2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". The Journal of Biological Chemistry. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
• Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
• Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochemical and Biophysical Research Communications. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.
• Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling. 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.
• Narita T, Amano F, Yoshizaki K, Nishimoto N, Nishimura T, Tajima T, Namiki H, Taniyama T (2001). "Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization". Cytogenetics and Cell Genetics. 93 (1–2): 133–4. doi:10.1159/000056966. PMID 11474197.
• Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.
• Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
• Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (August 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". The Journal of Biological Chemistry. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
• Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I (July 2002). "Ruk is ubiquitinated but not degraded by the proteasome". European Journal of Biochemistry. 269 (14): 3402–8. doi:10.1046/j.1432-1033.2002.03031.x. PMID 12135478.
• Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
• Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (September 2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors". Proceedings of the National Academy of Sciences of the United States of America. 99 (19): 12191–6. doi:10.1073/pnas.192462299. PMC 129420. PMID 12218189.
• Buchman VL, Luke C, Borthwick EB, Gout I, Ninkina N (July 2002). "Organization of the mouse Ruk locus and expression of isoforms in mouse tissues". Gene. 295 (1): 13–17. doi:10.1016/S0378-1119(02)00821-1. PMID 12242006.
• Tibaldi EV, Reinherz EL (March 2003). "CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities". International Immunology. 15 (3): 313–29. doi:10.1093/intimm/dxg032. PMID 12618476.
• Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH (June 2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85". The Journal of Biological Chemistry. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097.