SFRS10

Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
File:PBB Protein SFRS10 image.jpg PDB rendering based on 2cqc.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2cqc​
Identifiers
Symbols	SFRS10 ; DKFZp686F18120; Htra2-beta; SRFS10; TRA2-BETA; TRA2B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20965
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SFRS10 200893 at tn.png
File:PBB GE SFRS10 200892 s at tn.png
File:PBB GE SFRS10 210180 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila), also known as SFRS10, is a human gene.

Further reading

• Matsuo N, Ogawa S, Imai Y; et al. (1996). "Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation". J. Biol. Chem. 270 (47): 28216–22. PMID 7499316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.CS1 maint: Multiple names: authors list (link)
• Beil B, Screaton G, Stamm S (1997). "Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing". DNA Cell Biol. 16 (6): 679–90. PMID 9212162.CS1 maint: Multiple names: authors list (link)
• Imai Y, Matsuo N, Ogawa S; et al. (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Res. Mol. Brain Res. 53 (1–2): 33–40. PMID 9473574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tacke R, Tohyama M, Ogawa S, Manley JL (1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. PMID 9546399.CS1 maint: Multiple names: authors list (link)
• Nayler O, Cap C, Stamm S (1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.CS1 maint: Multiple names: authors list (link)
• Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. PMID 10339552.CS1 maint: Multiple names: authors list (link)
• Lai MC, Lin RI, Huang SY; et al. (2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins". J. Biol. Chem. 275 (11): 7950–7. PMID 10713112.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venables JP, Elliott DJ, Makarova OV; et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Hum. Mol. Genet. 9 (5): 685–94. PMID 10749975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Helmken C, Wirth B (2001). "Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy". Hum. Genet. 107 (6): 554–8. PMID 11153908.
• Young PJ, DiDonato CJ, Hu D; et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1". Hum. Mol. Genet. 11 (5): 577–87. PMID 11875052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hofmann Y, Wirth B (2003). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. PMID 12165565.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochim. Biophys. Acta. 1625 (2): 141–52. PMID 12531473.CS1 maint: Multiple names: authors list (link)
• El Yazidi-Belkoura I, Adriaenssens E, Dollé L; et al. (2003). "Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells". J. Biol. Chem. 278 (19): 16952–6. doi:10.1074/jbc.M300631200. PMID 12604596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang Z, Tang H, Havlioglu N; et al. (2003). "Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta". J. Biol. Chem. 278 (21): 18997–9007. doi:10.1074/jbc.M301800200. PMID 12649279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen X, Guo L, Lin W, Xu P (2004). "Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern". Cell Biol. Int. 27 (6): 491–6. PMID 12798777.CS1 maint: Multiple names: authors list (link)
• Helmken C, Hofmann Y, Schoenen F; et al. (2004). "Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1". Hum. Genet. 114 (1): 11–21. doi:10.1007/s00439-003-1025-2. PMID 14520560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Hawkins IC, Harvey CD; et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)