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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Symbols SERPINA4 ; KAL; KLST; KST; PI4; kallistatin
External IDs Template:OMIM5 HomoloGene48412
RNA expression pattern
File:PBB GE SERPINA4 213874 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4, also known as SERPINA4, is a human gene.[1]

See also


  1. "Entrez Gene: SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4".

Further reading

  • Chao J, Miao RQ, Chen V; et al. (2001). "Novel roles of kallistatin, a specific tissue kallikrein inhibitor, in vascular remodeling". Biol. Chem. 382 (1): 15–21. PMID 11258665.
  • Zhou GX, Chao L, Chao J (1993). "Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence". J. Biol. Chem. 267 (36): 25873–80. PMID 1334488.
  • Wang MY, Day J, Chao L, Chao J (1990). "Human kallistatin, a new tissue kallikrein-binding protein: purification and characterization". Adv. Exp. Med. Biol. 247B: 1–8. PMID 2558505.
  • Chen LM, Song Q, Chao L, Chao J (1995). "Cellular localization of tissue kallikrein and kallistatin mRNAs in human kidney". Kidney Int. 48 (3): 690–7. PMID 7474653.
  • Chai KX, Ward DC, Chao J, Chao L (1995). "Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4)". Genomics. 23 (2): 370–8. doi:10.1006/geno.1994.1513. PMID 7835886.
  • Chai KX, Chen LM, Chao J, Chao L (1993). "Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli". J. Biol. Chem. 268 (32): 24498–505. PMID 8227002.
  • Chao J, Schmaier A, Chen LM; et al. (1996). "Kallistatin, a novel human tissue kallikrein inhibitor: levels in body fluids, blood cells, and tissues in health and disease". J. Lab. Clin. Med. 127 (6): 612–20. PMID 8648266.
  • Wang DZ, Song Q, Chen LM; et al. (1996). "Expression and cellular localization of tissue kallikrein-kinin system in human adrenal gland". Am. J. Physiol. 271 (3 Pt 2): F709–16. PMID 8853434.
  • Ma JX, King LP, Yang Z; et al. (1997). "Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy". Curr. Eye Res. 15 (11): 1117–23. PMID 8950506.
  • Wolf WC, Harley RA, Sluce D; et al. (1999). "Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands". Histochem. Cell Biol. 110 (5): 477–84. PMID 9826127.
  • Wolf WC, Harley RA, Sluce D; et al. (1999). "Localization and expression of tissue kallikrein and kallistatin in human blood vessels". J. Histochem. Cytochem. 47 (2): 221–8. PMID 9889257.
  • Bläckberg M, Berling R, Ohlsson K (2000). "Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin". Pancreas. 19 (4): 325–34. PMID 10547191.
  • Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis". Biochim. Biophys. Acta. 1479 (1–2): 237–46. PMID 10862973.
  • Chen VC, Chao L, Chao J (2001). "A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein". J. Biol. Chem. 275 (51): 40371–7. doi:10.1074/jbc.M005691200. PMID 10991942.
  • Chen VC, Chao L, Pimenta DC; et al. (2001). "Identification of a major heparin-binding site in kallistatin". J. Biol. Chem. 276 (2): 1276–84. doi:10.1074/jbc.M005791200. PMID 11016932.
  • Pimenta DC, Oliveira A, Juliano MA, Juliano L (2001). "Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin". Biochim. Biophys. Acta. 1544 (1–2): 113–22. PMID 11341921.
  • Miao RQ, Agata J, Chao L, Chao J (2002). "Kallistatin is a new inhibitor of angiogenesis and tumor growth". Blood. 100 (9): 3245–52. doi:10.1182/blood-2002-01-0185. PMID 12384424.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Miao RQ, Chen V, Chao L, Chao J (2003). "Structural elements of kallistatin required for inhibition of angiogenesis". Am. J. Physiol., Cell Physiol. 284 (6): C1604–13. doi:10.1152/ajpgi.00524.2002. PMID 12734113.

External links

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