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Skp, Cullin, F-box containing complex. A multi-protein complex catalyzing the ubiquitylation of proteins destined for proteasomal degradation. Protein substrates are recognized by an F-box protein and delivered to the E3 ligase through the bridging protein, Skp. Cullin is the major scaffold of the SCF, as dogma indicates its binding of Skp, the ring-finger catalytic protein (eg ROC1), and recruitment of E2.
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