Reverse Krebs cycle

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The citric acid cycle, which can be run in reverse

The reverse Krebs cycle (also known as the reverse tricarboxylic acid cycle, the reverse TCA cycle, or the reverse citric acid cycle) is a sequence of chemical reactions that are used by some bacteria to produce carbon compounds from carbon dioxide and water.

The reaction is basically the Citric acid cycle run in reverse. Where the Krebs cycle takes complex carbon molecules in the form of sugars and reduces them to CO2 and water, the reverse cycle takes CO2 and water to make carbon compounds. This process is used by some bacteria to synthesis carbon compounds, sometimes using hydrogen or sulphates as electron donors.[1][2] In this process it can be seen as an alternative to the far more common photosynthesis production of organic molecules.

The reaction is one of the possible candidates for prebiotic early earth conditions and so is of interest in the origin of life research. It has been found that some of the steps can be catalysed by minerals.[3]

See also


  1. Evans MC (1966). "A new ferredoxin-dependent carbon reduction cycle in a photosynthetic bacterium". Proc Natl Acad Sci U S A. 55 (4): 928–34. PMID 5219700. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)
  2. Buchanan BB (1990). "A reverse KREBS cycle in photosynthesis: consensus at last". Photosynth Res. 24: 47–53. PMID 11540925. Unknown parameter |coauthors= ignored (help)
  3. Xiang V. Zhang (2006). "Driving Parts of Krebs Cycle in Reverse through Mineral Photochemistry". J. Am. Chem. Soc. 128 (50): 16032–16033. doi:10.1021/ja066103k. PMID 17165745. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)

External links