Repulsive guidance molecule

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Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin). RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth.[1]

Family members

RGM domain family, member A
Identifiers
SymbolRGMA
Alt. symbolsRGM
Entrez56963
HUGO30308
OMIM607362
RefSeqNM_020211
UniProtQ96B86
Other data
LocusChr. 15 q26.1
RGM domain family, member B
Identifiers
SymbolRGMB
Alt. symbolsDRAGON
Entrez285704
HUGO26896
OMIM612687
RefSeqNM_173670
UniProtQ6NW40
Other data
LocusChr. 5 q21.1
hemochromatosis type 2
Identifiers
SymbolHFE2
Alt. symbolsRGMC, HJV, hemojuvelin
Entrez148738
HUGO4887
OMIM608374
RefSeqNM_145277
UniProtQ6ZVN8
Other data
LocusChr. 1 q21.2

References

  1. Severyn CJ, Shinde U, Rotwein P (September 2009). "Molecular biology, genetics and biochemistry of the repulsive guidance molecule family". Biochem. J. 422 (3): 393–403. doi:10.1042/BJ20090978. PMC 4242795. PMID 19698085.

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