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RasGAP (Ras GTPase activating protein) is a 120-kDa cytosolic protein that provides two principal activities:

  • Inactivation of Ras from its active GTP-bound form to its unactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain
  • Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains


RasGAP contains one SH3 domain and two SH2 domains, a PH domain, and a GAP domain.

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