RAC3 (gene)

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
File:PBB Protein RAC3 image.jpg PDB rendering based on 1e96.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e96​, 1foe​, 1g4u​, 1he1​, 1hh4​, 1i4d​, 1i4l​, 1i4t​, 1mh1​, 2c2h​, 2fju​, 2g0n​, 2h7v​, 2ic5​, 2nz8​, 2ov2​, 2p2l​
Identifiers
Symbols	RAC3 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68433
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RAC3 206103 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), also known as RAC3, is a human gene.

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.

Further reading

• Didsbury J, Weber RF, Bokoch GM; et al. (1989). "rac, a novel ras-related family of proteins that are botulinum toxin substrates". J. Biol. Chem. 264 (28): 16378–82. PMID 2674130.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Haataja L, Groffen J, Heisterkamp N (1997). "Characterization of RAC3, a novel member of the Rho family". J. Biol. Chem. 272 (33): 20384–8. PMID 9252344.CS1 maint: Multiple names: authors list (link)
• Courjal F, Chuchana P, Theillet C, Fort P (1997). "Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes". Genomics. 44 (2): 242–6. doi:10.1006/geno.1997.4871. PMID 9299243.CS1 maint: Multiple names: authors list (link)
• Mira JP, Benard V, Groffen J; et al. (2000). "Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 185–9. PMID 10618392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soutoglou E, Papafotiou G, Katrakili N, Talianidis I (2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. 275 (17): 12515–20. PMID 10777539.CS1 maint: Multiple names: authors list (link)
• Morris CM, Haataja L, McDonald M; et al. (2000). "The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours". Cytogenet. Cell Genet. 89 (1–2): 18–23. PMID 10894930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gnanapragasam VJ, Leung HY, Pulimood AS; et al. (2002). "Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer". Br. J. Cancer. 85 (12): 1928–36. doi:10.1054/bjoc.2001.2179. PMID 11747336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haataja L, Kaartinen V, Groffen J, Heisterkamp N (2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. 277 (10): 8321–8. doi:10.1074/jbc.M105363200. PMID 11756406.CS1 maint: Multiple names: authors list (link)
• De Langhe S, Haataja L, Senadheera D; et al. (2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int. J. Mol. Med. 9 (5): 451–9. PMID 11956649.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang A, Yeung PL, Li CW; et al. (2004). "Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators". J. Biol. Chem. 279 (32): 33799–805. doi:10.1074/jbc.M403997200. PMID 15184363.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hwang SL, Chang JH, Cheng TS; et al. (2006). "Expression of Rac3 in human brain tumors". Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 12 (5): 571–4. doi:10.1016/j.jocn.2004.08.013. PMID 15993075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan AY, Coniglio SJ, Chuang YY; et al. (2005). "Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion". Oncogene. 24 (53): 7821–9. doi:10.1038/sj.onc.1208909. PMID 16027728.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF (2006). "Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells". Breast Cancer Res. 7 (6): R965–74. doi:10.1186/bcr1329. PMID 16280046.CS1 maint: Multiple names: authors list (link)
• Watabe-Uchida M, John KA, Janas JA; et al. (2006). "The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18". Neuron. 51 (6): 727–39. doi:10.1016/j.neuron.2006.07.020. PMID 16982419.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hajdo-Milasinović A, Ellenbroek SI, van Es S; et al. (2007). "Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells". J. Cell. Sci. 120 (Pt 4): 555–66. doi:10.1242/jcs.03364. PMID 17244648.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)