Glutamine-rich protein 2 is a protein that in humans is edcoded by the QRICH2 gene on human chromosome 17.[1][2] The function of QRICH2 protein is mostly unknown, but it has been shown that QRICH2 gene contains a high molecular weight Glutenin domain and an ATPase involved domain.[2] QRICH2 gene is highly expressed in testis,[3] and the subcellular location of QRICH2 protein is in the nucleus.[4]
QRICH2 mRNA is 5411 bp long, and its chromosomal location in human is 17q25.1. QRICH2 mRNA has 19 exons and it contains two main function domains: a high molecular weight Glutenin domain (amino acid 446-979) and an ATPase involved domain (amino acid 1036-1413). QRICH2 locates between UBAL D2 gene and PRPSAP1 gene on chromosome 17.[5] There is no predicted stem loop structure on QRICH2 mRNA because there isn't any complementary RNA sequences.[6]
Protein
QRICH2 protein is 1663 amino acids long, and 10.9% of the amino acids are Glutamine (Q). 38% of the QRICH2 protein secondary structure is alpha-helix, 39% is beta-sheet and 13% is turning.[7][8] The human tissue type with the highest level of QRICH2 expression is testis, and this result is confirmed by the Gene Expression Profile for mouse and dog too.[9] The subcellular location of QRICH2 protein is in the nucleus. QRICH2 is a soluble protein, its average hydrophobicity is -0.5995.[10] QRICH2 protein interact with a number of other proteins including SSSCA1, TSSC1, GAPDH, NUP98 and SNAI1.[1]
FLJ25737 mRNA sequences[12] perfectly match with two regions on the QRICH2 mRNA (bp 3157-4302 on QRICH2 match with bp 1-1146 on FLJ25737, bp 4998-5307 on QRICH2 match with bp 1140-1499 on FLJ25737). However, FLJ25737 locates on chromosome 7 and QRICH2 locates on chromosome 17.
Species
Protein name
Accession(Protein)
Length(aa)
E-value
Identity
Coverage
Location
Human
Spermine like protein 1
NP_001012998.2
632
6.00e-46
34%
39%
Xq21.1
Human
Protein piccolo isoform 1
NP_149015.2
5142
3.00e-10
30%
33%
7q11.23
Orthologs
Species
Common name
Divergence
(Million years ago)
Accession(Protein)
Length(aa)
Identity
Coverage
Rattus norvegicus
Brown rat
92.3
XP_577148.4
1971
51%
99%
Nomascus leucogenys
Gibbon
20.4
XP_003279182.2
1768
80%
99%
Canis lupus familiaris
Dog
94.2
XP_533125.3
1936
67%
99%
Loxodonta africana
Elephant
98.7
XP_003417424.1
1973
65%
99%
Ailuropoda melanoleuca
Panda
94.2
XP_002919929.1
1903
64%
99%
Otolemur garnettii
Bushbaby
74
XP_003785524.1
1963
63%
99%
Sus scrofa
Boar
94.2
XP_003131230.1
1983
63%
99%
Cavia porcellus
Guinea pig
92.3
XP_003461498
1852
61%
99%
Felis catus
Cat
94.2
XP_003997276.1
1755
61%
98%
Papio anubis
Babbon
29
XP_003913523.1
2043
80%
97%
Gorilla gorilla
Gorilla
8.8
XP_004041087
507
99%
30%
Mus musculus
House mouse
92.3
NP_001028439.1
592
77%
30%
QRICH2 protein has well conserved orthologs in many species. The orthologous protein sequences match very well at the region where the high molecular weight Glutenin domain and ATPase involved domain is.
Function
The function of QRICH2 protein is mostly unknown. QRICH2 has been shown to belong to the common expression groups on human chromosome 17. The following genes belonged to the common expression groups on chromosome 17:[13]NCOR1, GFAP, QRICH2, ANAPC11 and PER1. QRICH2 may also be an up-regulated gene involved in cell adhesion and cellular morphogenesis.[14] The high expression of QRICH2 gene in testis may suggest that QRICH2 protein has some functions related to hormone production in males. QRICH2 protein has some sequence similarities with the spermidine/spermine N(1)-acetyl-like protein 1 in several species.[11]
↑Chou PY, Fasman GD (1978). "Prediction of the secondary structure of proteins from their amino acid sequence". Adv. Enzymol. Relat. Areas Mol. Biol. 47: 45–148. doi:10.1002/9780470122921.ch2. PMID364941.