Pulmonary sequestration

Jump to: navigation, search
Pulmonary sequestration
ICD-10 Q33.2
ICD-9 748.5
DiseasesDB 32120
eMedicine ped/2628  radio/585
MeSH D001998

WikiDoc Resources for Pulmonary sequestration

Articles

Most recent articles on Pulmonary sequestration

Most cited articles on Pulmonary sequestration

Review articles on Pulmonary sequestration

Articles on Pulmonary sequestration in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Pulmonary sequestration

Images of Pulmonary sequestration

Photos of Pulmonary sequestration

Podcasts & MP3s on Pulmonary sequestration

Videos on Pulmonary sequestration

Evidence Based Medicine

Cochrane Collaboration on Pulmonary sequestration

Bandolier on Pulmonary sequestration

TRIP on Pulmonary sequestration

Clinical Trials

Ongoing Trials on Pulmonary sequestration at Clinical Trials.gov

Trial results on Pulmonary sequestration

Clinical Trials on Pulmonary sequestration at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Pulmonary sequestration

NICE Guidance on Pulmonary sequestration

NHS PRODIGY Guidance

FDA on Pulmonary sequestration

CDC on Pulmonary sequestration

Books

Books on Pulmonary sequestration

News

Pulmonary sequestration in the news

Be alerted to news on Pulmonary sequestration

News trends on Pulmonary sequestration

Commentary

Blogs on Pulmonary sequestration

Definitions

Definitions of Pulmonary sequestration

Patient Resources / Community

Patient resources on Pulmonary sequestration

Discussion groups on Pulmonary sequestration

Patient Handouts on Pulmonary sequestration

Directions to Hospitals Treating Pulmonary sequestration

Risk calculators and risk factors for Pulmonary sequestration

Healthcare Provider Resources

Symptoms of Pulmonary sequestration

Causes & Risk Factors for Pulmonary sequestration

Diagnostic studies for Pulmonary sequestration

Treatment of Pulmonary sequestration

Continuing Medical Education (CME)

CME Programs on Pulmonary sequestration

International

Pulmonary sequestration en Espanol

Pulmonary sequestration en Francais

Business

Pulmonary sequestration in the Marketplace

Patents on Pulmonary sequestration

Experimental / Informatics

List of terms related to Pulmonary sequestration

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

A pulmonary sequestration, also known as a bronchopulmonary sequestration or a cystic lung lesion, is a medical condition where a piece of tissue that develops into lung tissue is not attached to the pulmonary blood supply and does not communicate with the other lung tissue. Often it gets its blood supply from the thoracic aorta. Communication is a medical phrase indicating that it is not connected to the standard bronchial airways and that it performs no function in respiration.

This condition is normally detected in children and is generally held to be congenital in nature. The treatment for this is a segmentectomy via a thoracotomy. More and more, these lesions are diagnosed by prenatal ultrasound.

Variations

There are two different kinds of pulmonary sequestrations, intralobar and extralobar. The generally accepted difference between these seems to whether or not the sequestration has its own pleura, although some thoracic surgeons seem to prefer a definition that relates to the degree of vascular connection for the sequestration.

Symptoms

Symptoms can vary greatly, but they include a persistent dry cough.

Diagnosis

Sequestrations can be identified in-utero via an abnormal artery on ultrasound. The gold standard for diagnosis is pulmonary angiography. But since it is a very invasive procedure, it is getting replaced by CT Scan with a contrasting fluid, as the investigation of choice. Further studies are required for comparing sensitivity and specificity of angiograms versus ct scans in diagnosing pulmonary sequestration.

Complications

Failure to have a pulmonary sequestration removed can lead to a number of complications. These include:

  • It can be fatal if you have hemorrhage of the blood vessels
  • It can cause cardiovascular problems due to the creation of a shunt where blood flows in a shortcut through the feed off of the aorta.
  • It is necessary to prevent long-term infections. Things like tuberculosis, aspergillosis, bronchial carcinoid, brunchogenic squamous cell carcinoma.

Treatment

Usually the sequestration is removed after birth via surgery. In most cases this surgery is safe and effective; the child will grow up to have normal lung function.

In a few instances, fetuses with sequestrations develop problematic fluid collections in the chest cavity. In these situations a Harrison catheter shunt can be used to drain the chest fluid into the amniotic fluid.

In rare instances where the fetus has a very large lesion, resuscitation after delivery can be dangerous. In these situations a specialized delivery for management of the airway compression can be planned called the EXIT procedure.

Sources

  • Truitt AK, Carr SR, Cassese J, Kurkchubasche AG, Tracy TF Jr, Luks FI. (2006). "Perinatal management of congenital cystic lung lesions in the age of minimally invasive surgery". J Pediatr Surg: 41:893-896.
  • Savic B, Birtel FJ, Tholen W, Funke HD, Knoche R. (1979). "Lung seqestration: report of seven cases and review of 540 published cases". Thorax: 34:96-101.
  • Fabre O, Porte H, Godart F, Rey C, Wurtz A. (1998). "Long-Term Cardiovascular Consequences of Undiagnosed Intralobar Pulmonary Sequestration". Annals of Thoracic Surgery: 65, 1144–6.
  • Ferguson (1983). "Congenital lesion of the lungs and emphysema". Gibbons surgery of the Chest (4th ? ed.). WB Saunders. pp. 668–709. ISBN Unknown.
  • Rubin E, Garcia H, Horowitz M, Guerra J. (1994). "Fatal Massive Hemoptysia Secondary to Intralobar Sequestration". Chest: 954–955.
  • Sabiston D, Spencer F. Surgery of the Chest (6th ed.). pp. 853–862.


Cost Effectiveness of Pulmonary sequestration

| group5 = Clinical Trials Involving Pulmonary sequestration | list5 = Ongoing Trials on Pulmonary sequestration at Clinical Trials.govTrial results on Pulmonary sequestrationClinical Trials on Pulmonary sequestration at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pulmonary sequestration | list6 = US National Guidelines Clearinghouse on Pulmonary sequestrationNICE Guidance on Pulmonary sequestrationNHS PRODIGY GuidanceFDA on Pulmonary sequestrationCDC on Pulmonary sequestration


| group7 = Textbook Information on Pulmonary sequestration | list7 = Books and Textbook Information on Pulmonary sequestration


| group8 = Pharmacology Resources on Pulmonary sequestration | list8 = AND (Dose)}} Dosing of Pulmonary sequestrationAND (drug interactions)}} Drug interactions with Pulmonary sequestrationAND (side effects)}} Side effects of Pulmonary sequestrationAND (Allergy)}} Allergic reactions to Pulmonary sequestrationAND (overdose)}} Overdose information on Pulmonary sequestrationAND (carcinogenicity)}} Carcinogenicity information on Pulmonary sequestrationAND (pregnancy)}} Pulmonary sequestration in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Pulmonary sequestration


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Pulmonary sequestration | list9 = AND (pharmacogenomics)}} Genetics of Pulmonary sequestrationAND (pharmacogenomics)}} Pharmacogenomics of Pulmonary sequestrationAND (proteomics)}} Proteomics of Pulmonary sequestration


| group10 = Newstories on Pulmonary sequestration | list10 = Pulmonary sequestration in the newsBe alerted to news on Pulmonary sequestrationNews trends on Pulmonary sequestration


| group11 = Commentary on Pulmonary sequestration | list11 = Blogs on Pulmonary sequestration

| group12 = Patient Resources on Pulmonary sequestration | list12 = Patient resources on Pulmonary sequestrationDiscussion groups on Pulmonary sequestrationPatient Handouts on Pulmonary sequestrationDirections to Hospitals Treating Pulmonary sequestrationRisk calculators and risk factors for Pulmonary sequestration


| group13 = Healthcare Provider Resources on Pulmonary sequestration | list13 = Symptoms of Pulmonary sequestrationCauses & Risk Factors for Pulmonary sequestrationDiagnostic studies for Pulmonary sequestrationTreatment of Pulmonary sequestration

| group14 = Continuing Medical Education (CME) Programs on Pulmonary sequestration | list14 = CME Programs on Pulmonary sequestration

| group15 = International Resources on Pulmonary sequestration | list15 = Pulmonary sequestration en EspanolPulmonary sequestration en Francais

| group16 = Business Resources on Pulmonary sequestration | list16 = Pulmonary sequestration in the MarketplacePatents on Pulmonary sequestration

| group17 = Informatics Resources on Pulmonary sequestration | list17 = List of terms related to Pulmonary sequestration


}}



Linked-in.jpg