|P. mirabilis on an XLD agar plate.|
P. mirabilis on an XLD agar plate.
Proteus mirabilis is a Gram-negative, facultatively anaerobic bacterium. It shows swarming, motility, and urease activity. P. mirabilis causes 90% of all 'Proteus' infections. It belongs to the Tribe Proteae.
An alkaline urine sample is a possible sign of P. mirabilis.
P. mirabilis can be diagnosed in the lab due to characteristic swarming motility, and inability to metabolize lactose (on a MacConkey agar plate, for example.) Also P. mirabilis produces a very distinct odour.
This rod shaped bacterium has the ability to produce high levels of urease. Urease hydrolyzes urea to ammonia, NH3+ and thus makes the urine more alkaline. If left untreated, the increased alkalinity can lead to the formation of crystals of struvite, calcium carbonate, and/or apatite. The bacteria can be found throughout the stones, and these bacteria lurking in the stones can reinitiate infection after antibiotic treatment. Once the stones develop, over time they may grow large enough to cause obstruction and renal failure. Proteus can also cause wound infections, septicemia and pneumonias, mostly in hospitalized patients.
P. mirabilis is generally susceptible to most antibiotics apart from tetracycline, however 10%–20% of P. mirabilis strains are also resistant to first generation cephalosporins and ampicillins.
- Proteus mirabilis
Return to Top
- Proteus mirabilis
- Preferred regimen (1): Ampicillin 500 mg PO q6h or 2 g IV q6h
- Preferred regimen (2): Cefuroxime 250 mg PO bid or 750 mg IV q8h
- Preferred regimen (3): Ciprofloxacin 250-500 mg PO bid or 400 mg IV q12h
- Preferred regimen (4): Levofloxacin 500 mg PO OD or 500 mg IV q24h
- Note: Duration of treatment for uncomplicated UTI 3 days, pyelonephritis 7-14 days, complicated UTI 10-21 days and bacteremia is 7-14 days
P. mirabilis can utilize urea and citrate. It can produce hydrogen sulfide gas, and forms clear films on growth media. It is motile, possessing peritrichous flagella, and is known for its swarming ability. It is commonly found in the intestinal tract of humans. P. mirabilis is not pathogenic in guinea pigs or chickens. It has the distinction of being the only pathogenic organism with a virulence factor named for late rock musician Frank Zappa. Noteworthy is the ability of this species to inhibit growth of unrelated strains resulting in a macroscopically visible line of reduced bacterial growth where two swarming strains intersect. This line is named Dienes line after its discoverer Louis Dienes.
The micro-organism tests:
- Indole negative and Nitrogen Reductase positive (no gas bubble produced)
- Methyl Red positive and Vogues-Proskauer negative
- Catalase positive and Cytochrome Oxidase negative
- Phenylalanine Deaminase positive
Proteus mirabilis bacteria grown on a xylose-lysine-deoxycholate (XLD) agar plate. From Public Health Image Library (PHIL). 
- "Proteus mirabilis and Urinary Tract Infection" .
- Proteus Genome Projects from Genomes OnLine Database
- Esipov, Sergei E. and J. A. Shapiro (1998). "Kinetic model of Proteus mirabilis swarm colony development". Journal of Mathematical Biology. 36 (3). doi:10.1007/s002850050100.
- Frénod, Emmanuel (2006). "Existence result for a model of Proteus mirabilis swarm". Differential and integral equations. 19 (6): 697–720.
- Gué, Michaël, Virginie Dupont, Alain Dufour, and Olivier Sire (2001). "Bacterial swarming: A biological time-resolved FTIR-ATR study of Proteus mirabilis swarm-cell differentiation". Biochemistry. 40 (39): 11938–11945. doi:10.1021/bi010434m.
- O Rauprich, M Matsushita, CJ Weijer, F Siegert, SE Esipov and JA Shapiro (1996). "Periodic phenomena in Proteus mirabilis swarm colony development". Journal of Bacteriology. 178 (22): 6525–6538.
- ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
- ↑ "Public Health Image Library (PHIL)".