Protein:HSD11B2

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hydroxysteroid (11-beta) dehydrogenase 2
Identifiers
SymbolHSD11B2
Entrez3291
HUGO5209
OMIM218030
RefSeqNM_000196
UniProtP80365
Other data
EC number1.1.1.146
LocusChr. 16 q22

An NAD+-dependent enzyme expressed in aldosterone-selective tissues.

In these tissues, HSD11B2 oxidizes cortisol to cortisone and prevents illicit activation of the mineralocorticoid receptor.

Inhibition of this enzyme results in a condition known as pseudohyperaldosteronism


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