ProSavin
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ProSavin is an experimental drug believed to be of use in the treatment of Parkinson's Disease. It is administered to the striatum in the brain, inducing production of dopamine.[1]
It is manufactured by Oxford BioMedica, who plan to start European Phase I and Phase II clinical trials in 2007. Animal trials have been a success, with dopamine levels restored without the side effects associated with other current treatments for Parkinson's.[2]
Mechanism of Action
Prosavin uses Oxford BioMedica's Lentivector delivery system to transfer three genes, aromatic amino acid dopa decarboxylase, tyrosine hydroxylase and GTP-cyclohydrolase 1, to the striatum in the brain, reprogramming transduced cells to secrete dopamine.[3]
See also
References
- ↑ Oxford BioMedica. Drug Information Page. Retrieved on March 29, 2007.
- ↑ Daily Telegraph. Investor Information. Retrieved on March 29, 2007.
- ↑ Oxford BioMedica . Drug Advanced Information Page. Retrieved on April 5, 2007.