Primary cutaneous follicle centre lymphoma staging
|
Primary cutaneous follicle centre lymphoma Microchapters |
|
Differentiating Primary cutaneous follicle centre lymphoma from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Primary cutaneous follicle centre lymphoma staging On the Web |
|
American Roentgen Ray Society Images of Primary cutaneous follicle centre lymphoma staging |
|
Primary cutaneous follicle centre lymphoma staging in the news |
|
Directions to Hospitals Treating Splenic marginal zone lymphoma |
|
Risk calculators and risk factors for Primary cutaneous follicle centre lymphoma staging |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The staging of primary cutaneous follicle centre lymphoma is based on the International Society for Cutaneous Lymphomas (ISCL) / EORTC proposal on TNM classification of cutaneous lymphoma other than mycosis fungoides / sezary syndrome.[1]
Staging
The staging of primary cutaneous follicle centre lymphoma is based on the International Society for Cutaneous Lymphomas (ISCL) / EORTC proposal on TNM classification of cutaneous lymphoma other than mycosis fungoides / sezary syndrome.[1]
| Name | Stage | Description |
|---|---|---|
| T | ||
| T1 | Solitary skin involvement | |
| T1a | A solitary lesion <5 cm diameter | |
| T1 b | A solitary >5 cm diameter | |
| T2 | Regional skin involvement: multiple lesions limited to 1 body region or 2 contiguous body regions | |
| T2a | All-disease-encompassing in a <15-cm-diameter circular area | |
| T2 b | All-disease-encompassing in a >15- and <30-cm-diameter circular area | |
| T2 b | All-disease-encompassing in a >30-cm-diameter circular area | |
| T3 | Generalized skin involvement | |
| T3a | Multiple lesions involving 2 noncontiguous body regions | |
| T3b | Multiple lesions involving ≥3 body regions | |
| N | ||
| N0 | No clinical or pathologic lymph node involvement | |
| N1 | Involvement of 1 peripheral lymph node region that drains an area of current or prior skin involvement | |
| N2 | Involvement of 2 or more peripheral lymph node regions or involvement of any lymph node region† that does not drain an area of current or prior skin involvement | |
| N3 | Involvement of central lymph nodes | |
| M | ||
| M0 | No evidence of extracutaneous non–lymph node disease | |
| M1 | Extracutaneous non–lymph node disease present |
| International Society for Cutaneous Lymphomas (ISCL) / EORTC recommendations for staging evaluation in cutaneous lymphomas other than mycosis fungoides / sezary syndrome[1]
|
|---|
| Complete history/review of systems and physical examination |
| Laboratory studies |
| Complete blood count, comprehensive serum chemistries, serum LDH |
| Whenever indicated, relevant flow cytometric studies of peripheral blood mononuclear cells |
| Imaging studies |
| CT of chest, abdomen and pelvis with contrast alone or with whole-body PET (18F-FDG); include CT or ultrasound of neck if clinically indicated |
| Whole-body integrated PET/CT (as alternative imaging study to the standard contrast-enhanced CT) |
| Bone marrow biopsy and aspirate |
| Required in cutaneous lymphomas with intermediate to aggressive clinical behavior as categorized in the WHO-EORTC classification |
| Should be considered in cutaneous lymphomas with indolent clinical behavior, but not required unless indicated by other staging assessments |
| Additional studies as indicated clinically |
References
- ↑ 1.0 1.1 1.2 1.3 Kim, Y. H.; Willemze, R.; Pimpinelli, N.; Whittaker, S.; Olsen, E. A.; Ranki, A.; Dummer, R.; Hoppe, R. T. (2007). "TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC)". Blood. 110 (2): 479–484. doi:10.1182/blood-2006-10-054601. ISSN 0006-4971.