|Brain: Preoptic area|
|Preoptic area is 'PO', at left, in blue.|
This area propagates stimuli to either the heat-losing or heat-promoting centres of the hypothalamus.
- nucleus preopticus lateralis (lateral preoptic nucleus)
- nucleus preopticus medialis (medial preoptic nucleus) - also releases gonadotropin-releasing hormone
- nucleus preopticus medianus (median preoptic nucleus)
- nucleus preopticus periventricularis (periventricular preoptic nucleus)
Studies in female mice have shown that estrogen receptor-alpha declines in the pre-optic hypothalamus as they grow old. The female mice that were given a calorically restricted diet during the majority of their lives, maintained higher levels of ERα in the pre-optic hypothalamus than their non-calorically restricted counterparts.