Post-streptococcal glomerulonephritis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]


It is thought that post-streptococcal glomerulonephritis (PSGN) is caused by nephritogenic strains of group A beta-hemolytic streptococcus (GAS). The mechanism which leads to immunologic injury to the glomerulus include deposition of immune complexes with streptococcal antigenic components, then immune complexes are deposited in glomerular basement membrane and antibodies bind to the GBM.


The mechanism which leads to immunologic injury to the glomerulus are:[3]

Gross Pathology

  • On gross pathology, following features are seen:
    • Kidney are enlarged and pale in color

Microscopic Pathology

On microscopic histopathological analysis:

Source:By Nephron - Own work<ref/ ref>>
Source:By Nephron - Own work<ref/ ref>>

Immunofluorescence findings


  1. Yoshizawa N, Yamakami K, Fujino M, Oda T, Tamura K, Matsumoto K, Sugisaki T, Boyle MD (July 2004). "Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response". J. Am. Soc. Nephrol. 15 (7): 1785–93. PMID 15213266.
  2. Oda T, Yoshizawa N, Yamakami K, Tamura K, Kuroki A, Sugisaki T, Sawanobori E, Higashida K, Ohtomo Y, Hotta O, Kumagai H, Miura S (September 2010). "Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis". Hum. Pathol. 41 (9): 1276–85. doi:10.1016/j.humpath.2010.02.006. PMID 20708459.
  3. Rodríguez-Iturbe B, Batsford S (June 2007). "Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet". Kidney Int. 71 (11): 1094–104. doi:10.1038/ PMID 17342179.
  4. Sorger K, Gessler U, Hübner FK, Köhler H, Schulz W, Stühlinger W, Thoenes GH, Thoenes W (March 1982). "Subtypes of acute postinfectious glomerulonephritis. Synopsis of clinical and pathological features". Clin. Nephrol. 17 (3): 114–28. PMID 7067173.

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