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Polyglycylation is a form of posttranslational modification of glutamate residues of the carboxyl-terminal region tubulin in certain microtubules (eg axonemal) originally discovered in paramecium[1], and later shown in mammalian neurons as well[2].


  1. Redeker, V., Levilliers, N., Schmitter, J.M., Le Caer, J.P., Rossier, J., Adoutte, A., and Bré, M.H. (1994). Polyglycylation of tubulin: a posttranslational modification in axonemal microtubules. Science 266, 1688-1691 ( http://www.sciencemag.org/cgi/content/abstract/266/5191/1688 )
  2. Asok Banerjee Coordination of Posttranslational Modifications of Bovine Brain alpha -Tubulin. POLYGLYCYLATION OF Delta 2 TUBULIN J. Biol. Chem. 277: 46140-46144 ( http://www.jbc.org/cgi/content/full/277/48/46140 )