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Polybrene is a cationic polymer used to increase the efficiency of infection of certain cells with a retrovirus in cell culture. Polybrene acts by neutralizing the charge repulsion between the virions and cell surface. [1] It has other uses, including a role in protein sequencing.

The chemical name for Polybrene is 1,5-dimethyl-1,5-diazaundecamethylene polymethobromide, hexadimethrine bromide.


  1. Howard E. Davis, Matthew Rosinski , Jeffrey R. Morgan and Martin L. Yarmush; et al. (2004). "Charged Polymers Modulate Retrovirus Transduction via Membrane Charge Neutralization and Virus Aggregation". Biophysical Journal. 86 (2): 1234–42. PMID 14747357.